Clusters of Characterized Proteins

Clustering the characterized proteins for yjcH (putative small subunit of pyruvate transporter (yjcH-like)) in pyruvate catabolism

Or see other characterized proteins similar to yjcH

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Definition of yjcH

• Curated sequence GFF1742: required for pyruvate transport, with PS417_08865 (actP-like)
• Curated sequence AZOBR_RS02935: required for pyruvate transport, with AZOBR_RS02940
• Curated sequence Pf1N1B4_3672: required for pyruvate transport, with Pf1N1B4_3673 (actP-like)
• Curated sequence Pf6N2E2_5848: required for pyruvate transport, with Pf6N2E2_5849 (actP-like)
• Ignore hits to 18096 when looking for 'other' hits (DUF485 domain-containing inner membrane protein YjcH. required for glycolate transport, with actP)
• UniProt sequence E4PHQ1: SubName: Full=Membrane protein containing probable solute: sodium symporter, small subunit domain {ECO:0000313|EMBL:ADP97016.1};
• Curated sequence GFF345: small component of D-alanine uptake system, with Psest_0347 (actP-like)
• Comment: This is the yjcH-like small subunit. These are similar to E. coli b4068/yjcH/18096, involved in glycolate & acetate transport, so ignore that. Added Marinobacter HP15_1252 (E4PHQ1) because it has a specific phenotype (if mild) and fills the gap.

Fetched 6 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 6 of these sequences

Found 2 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 100-103 amino acids (not heteromeric)

PS417_08860 required for pyruvate transport, with PS417_08865 (actP-like) from Pseudomonas simiae WCS417
PFams: DUF485
103 amino acids: PaperBLAST, CDD, Compare to cluster

AZOBR_RS02935 required for pyruvate transport, with AZOBR_RS02940 from Azospirillum brasilense Sp245
PFams: DUF485
100 amino acids: PaperBLAST, CDD, Compare to cluster

Pf1N1B4_3672 required for pyruvate transport, with Pf1N1B4_3673 (actP-like) from Pseudomonas fluorescens FW300-N1B4
PFams: DUF485
103 amino acids: PaperBLAST, CDD, Compare to cluster

Pf6N2E2_5848 required for pyruvate transport, with Pf6N2E2_5849 (actP-like) from Pseudomonas fluorescens FW300-N2E2
PFams: DUF485
103 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 87-88 amino acids (1/2 heteromeric)

E4PHQ1 Membrane protein containing probable solute: sodium symporter, small subunit domain
88 amino acids: PaperBLAST, CDD, Compare to cluster

Psest_0346 small component of D-alanine uptake system, with Psest_0347 (actP-like) from Pseudomonas stutzeri RCH2
PFams: DUF4212
Heteromeric, 87 amino acids: PaperBLAST, CDD, Compare to cluster