Clusters of Characterized Proteins

Clustering the characterized proteins for mtlA (PTS system for polyols, EII-CBA components) in D-sorbitol (glucitol) catabolism

Or see other characterized proteins similar to mtlA

Or see all steps for D-sorbitol (glucitol) catabolism

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Definition of mtlA

• Curated sequence P00550: protein-Npi-phosphohistidine-D-mannitol phosphotransferase (EC 2.7.1.197). PTS system mannitol-specific EIICBA component; EC 2.7.1.-; EC 2.7.1.69. PTS system mannitol-specific EIICBA component; EIICBA-Mtl; EII-Mtl; EC 2.7.1.197. Mannitol porter (MtlA) (mannitol-1-P forming), the mannitol IICBA complex. mannitol-specific PTS enzyme IICBA component (EC 2.7.1.197; EC 2.7.1.198). mannitol-specific PTS enzyme IICBA component (EC 2.7.1.197; EC 2.7.1.198)
• Curated sequence Q9KKQ7: The mannitol/glucitol transporter, MtlA (IICBAMtl)
• Ignore hits to P42956 when looking for 'other' hits (PTS system, mannitol-specific IICBA component aka EIICBA-Mtl aka Mannitol-permease IIABC component aka Phosphotransferase enzyme II, CBA component aka EC 2.7.1.69 aka EII-Mtl, component of The mannitol porter (MtlA) (mannitol-1-P forming), MtlAF)
• Comment: polyol PTS system with EII-CBA all fused, known as mtlA in E. coli (TC 4.A.2.1.2). Also includes TC 4.A.2.1.12 (Q9KKQ7). TC 4.A.2.1.5 (P42956) is the B. subtilis mannitol transporter but probably has weak activity no sorbitol (PMC222339). so exclude it. Not known if the homologs from Geobacillus stearothermophilus (P50852) or Clostridium acetobutylicum (O65989) [which lack the A component], which are mannitol transporters, are capable of sorbitol transport

Fetched 2 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 2 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 637-649 amino acids (not heteromeric)

b3599 mannitol-specific PTS enzyme IICBA component (EC 2.7.1.197; EC 2.7.1.198) from Escherichia coli K-12 substr. MG1655
P00550 mannitol-specific PTS enzyme IICBA component (EC 2.7.1.197; EC 2.7.1.198) from Escherichia coli (strain K12)
PTM3C_ECOLI / P00550 PTS system mannitol-specific EIICBA component; EIICBA-Mtl; EII-Mtl; EC 2.7.1.197 from Escherichia coli (strain K12)
P00550 protein-Npi-phosphohistidine-D-mannitol phosphotransferase (EC 2.7.1.197) from Escherichia coli
TC 4.A.2.1.2 / P00550 Mannitol porter (MtlA) (mannitol-1-P forming), the mannitol IICBA complex from Escherichia coli
GB|AAC76623.1 PTS system mannitol-specific EIICBA component; EC 2.7.1.-; EC 2.7.1.69 from Escherichia coli K12
PFams: PTS_EIIC, PTS_IIB, PTS_EIIA_2
637 amino acids: PaperBLAST, CDD, Compare to cluster

TC 4.A.2.1.12 / Q9KKQ7 The mannitol/glucitol transporter, MtlA (IICBAMtl) from Vibrio cholerae
PFams: PTS_EIIC, PTS_IIB, PTS_EIIA_2
649 amino acids: PaperBLAST, CDD, Compare to cluster