Clusters of Characterized Proteins

Clustering the characterized proteins for levG (fructose PTS system (fructose 6-phosphate forming), EII-D component) in sucrose catabolism

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Definition of levG

• Curated sequence P26382: PTFD aka LEVG, component of Fructose group translocator, LevDEFG
• Curated sequence P69805: PTND aka MANZ aka PTSM aka GPTB aka B1819, component of The mannose (glucose, 2-deoxyglucose, glucosamine, N-acetylglucosamine, N-acetylmannosamine, mannosamine and fructose) PTS porter/group translocator, ManXYZ (Rephaeli and Saier 1980; Plumbridge 2015). Catalyzes xylose facilitated diffusion in lactobacilli. The order of D-sugar substrate affinities is: glucose > mannose > 2-deoxyglucose > N-acetylglucosamine > glucosamine > N-acetylmannosamine > mannosamine > fructose
• Curated sequence Q04GJ9: PTS system IID component, Man family, component of The hexose (glucose and fructose demonstrated) PTS uptake system
• Curated sequence Q5M5W8: ManN, component of The glucose/mannose/2-deoxyglucose/fructose phosphotransferase systems (phosphorylates without transport), ManLMN
• Ignore hits to P69805 when looking for 'other' hits (PTS system mannose-specific EIID component; EII-M-Man; EIID-Man; Mannose permease IID component. mannose-specific PTS enzyme IID component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193). mannose-specific PTS enzyme IID component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193))
• Ignore hits to Q5IRC0 when looking for 'other' hits (protein-Npi-phosphohistidine-D-mannose phosphotransferase (EC 2.7.1.191))
• Comment: Ignore SwissProt::P69805 which is nearly identical to P69805. Ignore Q5IRC0, whose specificity is unknown.

Fetched 4 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 4 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 275-304 amino acids (heteromeric)

TC 4.A.6.1.2 / P26382 PTFD aka LEVG, component of Fructose group translocator, LevDEFG from Bacillus subtilis
PFams: EIID-AGA
Heteromeric, 275 amino acids: PaperBLAST, CDD, Compare to cluster

TC 4.A.6.1.1 / P69805 PTND aka MANZ aka PTSM aka GPTB aka B1819, component of The mannose (glucose, 2-deoxyglucose, glucosamine, N-acetylglucosamine, N-acetylmannosamine, mannosamine and fructose) PTS porter/group translocator, ManXYZ (Rephaeli and Saier 1980; Plumbridge 2015). Catalyzes xylose facilitated diffusion in lactobacilli. The order of D-sugar substrate affinities is: glucose > mannose > 2-deoxyglucose > N-acetylglucosamine > glucosamine > N-acetylmannosamine > mannosamine > fructose from Escherichia coli
PFams: EIID-AGA
Heteromeric, 286 amino acids: PaperBLAST, CDD, Compare to cluster

TC 4.A.6.1.10 / Q04GJ9 PTS system IID component, Man family, component of The hexose (glucose and fructose demonstrated) PTS uptake system from Oenococcus oeni (strain BAA-331 / PSU-1)
PFams: EIID-AGA
Heteromeric, 304 amino acids: PaperBLAST, CDD, Compare to cluster

TC 4.A.6.1.7 / Q5M5W8 ManN, component of The glucose/mannose/2-deoxyglucose/fructose phosphotransferase systems (phosphorylates without transport), ManLMN from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
PFams: EIID-AGA
Heteromeric, 303 amino acids: PaperBLAST, CDD, Compare to cluster