Clusters of Characterized Proteins

Clustering the characterized proteins for homK (putative homoserine phosphotransferase) in L-threonine biosynthesis

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Definition of homK

• UniProt sequence Q8PX04: RecName: Full=2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Short=BPG-independent PGAM; Short=Phosphoglyceromutase; Short=aPGAM; EC=5.4.2.12;
• Comment: BT2402 (Q8PX04) is required for threonine synthesis (PMC7311316) and belongs to a family (TIGR02535) that was proposed replace the missing homoserine kinase. This family is also known as ThrB2 (PMC9026213). Homologs from Phocaeicola are also required for threonine synthesis (Surya Tripathi, personal communication). The HomK family is often encoded next to aspartate kinase and threonine synthase. It is related to phosphoglycerate mutases and might transfer phosphate groups from a donor such as phosphoenolpyruvate to homoserine. In GapMind, HomK is described separately from ThrB because it probably carries out a different reaction.

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Running BLASTp

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Singletons (0/1 heteromeric)

Q8PX04 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Short=BPG-independent PGAM; Short=Phosphoglyceromutase; Short=aPGAM; EC=5.4.2.12
397 amino acids: PaperBLAST, CDD