Clusters of Characterized Proteins

Clustering the characterized proteins for aldA (lactaldehyde dehydrogenase) in L-threonine catabolism

Or see other characterized proteins similar to aldA

Or see all steps for L-threonine catabolism

Or cluster curated proteins matching a keyword

Definition of aldA

• Curated proteins or TIGRFams with EC 1.2.1.22
• Ignore hits to items matching lactaldehyde dehydrogenase when looking for 'other' hits
• Comment: The EC number is for the NAD dependent reaction. There's also a NADP dependent reaction, sometimes given this EC, sometimes not.

Fetched 10 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 10 of these sequences

Found 2 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 463-495 amino acids (not heteromeric)

b1415 aldehyde dehydrogenase A (EC 1.2.1.22; EC 1.2.1.21) from Escherichia coli K-12 substr. MG1655
P25553 aldehyde dehydrogenase A (EC 1.2.1.22; EC 1.2.1.21) from Escherichia coli (strain K12)
P25553 lactaldehyde dehydrogenase (EC 1.2.1.22); D-glyceraldehyde dehydrogenase (NADP+) (EC 1.2.1.89) from Escherichia coli
PFams: Aldedh
479 amino acids: PaperBLAST, CDD, Compare to cluster

Q58806 lactaldehyde dehydrogenase subunit (EC 1.2.1.22) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
LADH_METJA / Q58806 Lactaldehyde dehydrogenase; EC 1.2.1.22 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Q58806 lactaldehyde dehydrogenase (EC 1.2.1.22) from Methanocaldococcus jannaschii
PFams: Aldedh
463 amino acids: PaperBLAST, CDD, Compare to cluster

Q97UA1 2,5-dioxopentanoate dehydrogenase subunit (EC 1.2.1.26) from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
KGSDH_SACS2 / Q97UA1 2,5-dioxopentanoate dehydrogenase; Aldehyde dehydrogenase T; Alpha-ketoglutaric semialdehyde dehydrogenase AldhT; EC 1.2.1.26 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Q97UA1 lactaldehyde dehydrogenase (EC 1.2.1.22); 2,5-dioxovalerate dehydrogenase (EC 1.2.1.26) from Saccharolobus solfataricus
PFams: Aldedh
478 amino acids: PaperBLAST, CDD, Compare to cluster

A3LNE3 NAD(P)⁺ L-lactaldehyde dehydrogenase (EC 1.2.1.22) from Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
PFams: Aldedh
495 amino acids: PaperBLAST, CDD, Compare to cluster

C1DMY3 NAD⁺-dependent L-lactaldehyde dehydrogenase (EC 1.2.1.22) from Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
PFams: Aldedh
477 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 689-730 amino acids (not heteromeric)

P40747 bifunctional L-rhamnulose 1-phosphate aldolase/lactaldehyde dehydrogenase (EC 4.1.2.19; EC 1.2.1.22) from Bacillus subtilis (strain 168)
PFams: Aldolase_II, adh_short, Epimerase, KR, adh_short_C2
689 amino acids: PaperBLAST, CDD, Compare to cluster

A9WGG0 bifunctional L-rhamnulose-phosphate aldolase/L-lactaldehyde dehydrogenase (EC 1.2.1.22; EC 4.1.2.19) from Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
PFams: Aldolase_II, adh_short, KR, adh_short_C2
730 amino acids: PaperBLAST, CDD, Compare to cluster

Echvi_1572 Lactaldehyde dehydrogenase (EC 1.2.1.22); Rhamnulose-1-phosphate aldolase (EC 4.1.2.19) from Echinicola vietnamensis KMM 6221, DSM 17526
PFams: Aldolase_II, adh_short, KR, adh_short_C2
702 amino acids: PaperBLAST, CDD, Compare to cluster

Dshi_2436 rhamnulose-1-phosphate aldolase (EC 4.1.2.19) / lactaldehyde dehydrogenase (EC 1.2.1.22) from Dinoroseobacter shibae DFL-12
PFams: Aldolase_II, adh_short, KR, adh_short_C2
700 amino acids: PaperBLAST, CDD, Compare to cluster

SMc02322 rhamnulose-1-phosphate aldolase (EC 4.1.2.19) / lactaldehyde dehydrogenase (EC 1.2.1.22) from Sinorhizobium meliloti 1021
PFams: Aldolase_II, adh_short, KR, adh_short_C2
699 amino acids: PaperBLAST, CDD, Compare to cluster