Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for iolA (malonate semialdehyde dehydrogenase (CoA-acylating)) in L-threonine catabolism

Or see other characterized proteins similar to iolA

Or see all steps for L-threonine catabolism

Or cluster curated proteins matching a keyword

Definition of iolA

Curated proteins or TIGRFams with EC 1.2.1.18
Ignore hits to items matching 1.2.1.27 when looking for 'other' hits
Ignore hits to Q9I702 when looking for 'other' hits (Putative 3-oxopropanoate dehydrogenase; EC 1.2.1.-)
Comment: Ignore similarity to methylmalonate semialdehyde dehydrogenase (EC 1.2.1.27), which often has this activity as well

Fetched 11 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 11 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 487-541 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

A0A081YAY7 malonate-semialdehyde dehydrogenase (EC 1.2.1.15); malonate-semialdehyde dehydrogenase (acetylating) (EC 1.2.1.18); methylmalonate-semialdehyde dehydrogenase (CoA-acylating) (EC 1.2.1.27) from Pseudomonas sp.
PFams: Aldedh
498 amino acids: PaperBLAST, CDD, Compare to cluster

P42412 (methyl)malonate-semialdehyde dehydrogenase monomer (EC 1.2.1.27; EC 1.2.1.18) from Bacillus subtilis (strain 168)
IOLA_BACSU / P42412 Malonate-semialdehyde dehydrogenase; MSA dehydrogenase; Methylmalonate-semialdehyde dehydrogenase; MMSA dehydrogenase; MMSDH; MSDH; EC 1.2.1.-; EC 1.2.1.27 from Bacillus subtilis (strain 168)
P42412 methylmalonate-semialdehyde dehydrogenase (CoA-acylating) (EC 1.2.1.27) from Bacillus subtilis
PFams: Aldedh
487 amino acids: PaperBLAST, CDD, Compare to cluster

MMSA_HUMAN / Q02252 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; MMSDH; Malonate-semialdehyde dehydrogenase [acylating]; Aldehyde dehydrogenase family 6 member A1; EC 1.2.1.18; EC 1.2.1.27 from Homo sapiens (Human)
Q02252 malonate-semialdehyde dehydrogenase (acetylating) (EC 1.2.1.18); methylmalonate-semialdehyde dehydrogenase (CoA-acylating) (EC 1.2.1.27) from Homo sapiens
PFams: Aldedh
535 amino acids: PaperBLAST, CDD, Compare to cluster

Q9EQ20 malonate-semialdehyde dehydrogenase (acetylating) (EC 1.2.1.18) from Mus musculus
PFams: Aldedh
535 amino acids: PaperBLAST, CDD, Compare to cluster

MMSA_RAT / Q02253 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; MMSDH; Malonate-semialdehyde dehydrogenase [acylating]; Aldehyde dehydrogenase family 6 member A1; EC 1.2.1.18; EC 1.2.1.27 from Rattus norvegicus (Rat)
PFams: Aldedh
535 amino acids: PaperBLAST, CDD, Compare to cluster

C8YX90 malonate-semialdehyde dehydrogenase (acetylating) (EC 1.2.1.18) from Halomonas sp. HTNK1
PFams: Aldedh
503 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1D8PM94 malonate semialdehyde dehydrogenase (CoA-acylating) (EC 1.2.1.18) from Candida albicans (strain SC5314 / ATCC MYA-2876)
PFams: Aldedh
541 amino acids: PaperBLAST, CDD, Compare to cluster

SMc00781 malonate-semialdehyde dehydrogenase (acetylating) (EC 1.2.1.18) from Sinorhizobium meliloti 1021
PFams: Aldedh
498 amino acids: PaperBLAST, CDD, Compare to cluster

PS417_10925 malonate-semialdehyde dehydrogenase (acetylating) (EC 1.2.1.18) from Pseudomonas simiae WCS417
PFams: Aldedh
499 amino acids: PaperBLAST, CDD, Compare to cluster

AO356_23175 malonate-semialdehyde dehydrogenase (acetylating) (EC 1.2.1.18) from Pseudomonas fluorescens FW300-N2C3
PFams: Aldedh
500 amino acids: PaperBLAST, CDD, Compare to cluster

Pf6N2E2_515 malonate-semialdehyde dehydrogenase (acetylating) (EC 1.2.1.18) from Pseudomonas fluorescens FW300-N2E2
PFams: Aldedh
500 amino acids: PaperBLAST, CDD, Compare to cluster