Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for ltaE (L-threonine aldolase) in L-threonine catabolism

Or see other characterized proteins similar to ltaE

Or see all steps for L-threonine catabolism

Or cluster curated proteins matching a keyword

Definition of ltaE

Curated proteins or TIGRFams with EC 4.1.2.5
Curated proteins or TIGRFams with EC 4.1.2.48
Ignore hits to P0A825 when looking for 'other' hits (glycine hydroxymethyltransferase (EC 2.1.2.1); low-specificity L-threonine aldolase (EC 4.1.2.48). serine hydroxymethyltransferase; EC 2.1.2.1. Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.1. serine hydroxymethyltransferase (EC 2.1.2.1). serine hydroxymethyltransferase (EC 2.1.2.1))
Ignore hits to D3DKC4 when looking for 'other' hits (Serine hydroxymethyltransferase; SHMT; Serine methylase; L-threonine/L-allo-threonine aldolase; EC 2.1.2.1; EC 4.1.2.48)
Ignore hits to CH_123166 when looking for 'other' hits (L-threonine aldolase)
Comment: Some serine hydroxymethyltransferases (glyA) are reported to carry out the L-threonine aldolase reaction, but the Km are high (see PMC219072 or PMID:22141341). CharProtDB::CH_123166 is annotated as threonine aldolase but without the EC number, and is nearly identical to O13427, which is a low-specificity threonine aldolase.

Fetched 13 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 13 of these sequences

Found 2 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 333-387 amino acids (not heteromeric)

O07051 L-allo-threonine aldolase subunit (EC 4.1.2.48) from Aeromonas jandaei
LTAA_AERJA / O07051 L-allo-threonine aldolase; L-allo-TA; L-allo-threonine acetaldehyde-lyase; EC 4.1.2.49 from Aeromonas jandaei
O07051 L-allo-threonine aldolase (EC 4.1.2.49) from Aeromonas jandaei
GB|BAA20404.1 L-allo-threonine aldolase; EC 4.1.2.- from Aeromonas jandaei
PFams: Beta_elim_lyase, Aminotran_1_2
338 amino acids: PaperBLAST, CDD, Compare to cluster

O13427 low-specificity L-threonine aldolase (EC 4.1.2.48) from Candida albicans
PFams: Beta_elim_lyase, Aminotran_1_2
374 amino acids: PaperBLAST, CDD, Compare to cluster

P37303 L-threonine aldolase subunit (EC 4.1.2.48) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
GLY1_YEAST / P37303 Low specificity L-threonine aldolase; Low specificity L-TA; TA; EC 4.1.2.48 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P37303 low-specificity L-threonine aldolase (EC 4.1.2.48) from Saccharomyces cerevisiae
PFams: Beta_elim_lyase
387 amino acids: PaperBLAST, CDD, Compare to cluster

b0870 low-specificity L-threonine aldolase (EC 4.1.2.48; EC 4.1.2.5; EC 4.1.2.26; EC 4.1.2.49) from Escherichia coli K-12 substr. MG1655
P75823 low-specificity L-threonine aldolase (EC 4.1.2.48; EC 4.1.2.26) from Escherichia coli (strain K12)
LTAE_ECOLI / P75823 Low specificity L-threonine aldolase; Low specificity L-TA; EC 4.1.2.48 from Escherichia coli (strain K12)
P75823 low-specificity L-threonine aldolase (EC 4.1.2.48) from Escherichia coli
GB|BAA20882.1 threonine aldolase; EC 4.1.2.5 from Escherichia coli K12
PFams: Beta_elim_lyase, Aminotran_1_2
333 amino acids: PaperBLAST, CDD, Compare to cluster

Q9X266 L-threonine aldolase (EC 4.1.2.5) from Thermotoga maritima
PFams: Beta_elim_lyase, Aminotran_1_2, DegT_DnrJ_EryC1, Cys_Met_Meta_PP, Aminotran_5
343 amino acids: PaperBLAST, CDD, Compare to cluster

GB|AAA72430.1 threonine aldolase; EC 4.1.2.5 from Saccharomyces cerevisiae
PFams: Beta_elim_lyase
387 amino acids: PaperBLAST, CDD, Compare to cluster

THA1_ARATH / Q8RXU4 Probable low-specificity L-threonine aldolase 1; Threonine aldolase 1; EC 4.1.2.48 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Beta_elim_lyase, Aminotran_1_2, DegT_DnrJ_EryC1, Cys_Met_Meta_PP
358 amino acids: PaperBLAST, CDD, Compare to cluster

THA2_ARATH / Q9FPH3 Probable low-specificity L-threonine aldolase 2; Threonine aldolase 2; EC 4.1.2.48 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Beta_elim_lyase, Aminotran_1_2
355 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 346-348 amino acids (not heteromeric)

A0T1V9 low-specificity L-threonine aldolase (EC 4.1.2.48) from Sinorhizobium arboris
PFams: Beta_elim_lyase
348 amino acids: PaperBLAST, CDD, Compare to cluster

O50584 low-specificity L-threonine aldolase (EC 4.1.2.48) from Pseudomonas sp.
PFams: Beta_elim_lyase
346 amino acids: PaperBLAST, CDD, Compare to cluster

Q88R13 L-threonine aldolase (EC 4.1.2.5) from Pseudomonas putida
PFams: Beta_elim_lyase
346 amino acids: PaperBLAST, CDD, Compare to cluster

PfGW456L13_1114 L-threonine aldolase (EC 4.1.2.5) from Pseudomonas fluorescens GW456-L13
PFams: Beta_elim_lyase
346 amino acids: PaperBLAST, CDD, Compare to cluster

AO353_07670 L-threonine aldolase (EC 4.1.2.5) from Pseudomonas fluorescens FW300-N2E3
PFams: Beta_elim_lyase
346 amino acids: PaperBLAST, CDD, Compare to cluster