Clusters of Characterized Proteins

Clustering the characterized proteins for tdcE (2-ketobutyrate formate-lyase) in L-threonine catabolism

Or see other characterized proteins similar to tdcE

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Definition of tdcE

• Curated sequence P42632: pyruvate formate-lyase 4/2-ketobutyrate formate-lyase. PFL-like enzyme TdcE; Keto-acid formate acetyltransferase; Keto-acid formate-lyase; Ketobutyrate formate-lyase; KFL; Pyruvate formate-lyase; PFL; EC 2.3.1.-; EC 2.3.1.54
• Curated sequence P09373: formate C-acetyltransferase (EC 2.3.1.54). pyruvate formate-lyase
• Ignore hits to items matching 2.3.1.54 when looking for 'other' hits
• Comment: This reaction is not linked to an EC number. E. coli tdcB (PF42632) and pflB (P09373) seem to be the only ones that are characterized. Many pyruvate-formate lyases (EC 2.3.1.54) can probably carry out this reaction, so they are ignored.

Fetched 2 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 2 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 760-764 amino acids (not heteromeric)

b0903 pyruvate formate-lyase from Escherichia coli K-12 substr. MG1655
P09373 formate C-acetyltransferase (EC 2.3.1.54) from Escherichia coli
PFams: PFL-like, Gly_radical
760 amino acids: PaperBLAST, CDD, Compare to cluster

TDCE_ECOLI / P42632 PFL-like enzyme TdcE; Keto-acid formate acetyltransferase; Keto-acid formate-lyase; Ketobutyrate formate-lyase; KFL; Pyruvate formate-lyase; PFL; EC 2.3.1.-; EC 2.3.1.54 from Escherichia coli (strain K12)
EW|b3114 pyruvate formate-lyase 4/2-ketobutyrate formate-lyase from Escherichia coli K12
PFams: PFL-like, Gly_radical
764 amino acids: PaperBLAST, CDD, Compare to cluster