Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for yvgN (methylglyoxal reductase (NADPH-dependent)) in L-threonine catabolism

Or see other characterized proteins similar to yvgN

Or see all steps for L-threonine catabolism

Or cluster curated proteins matching a keyword

Definition of yvgN

Curated proteins or TIGRFams with EC 1.1.1.283
Ignore hits to items matching 1.1.1.184 when looking for 'other' hits
Comment: 1.1.1.184 describes relatively non-specific ketone reductases, some of which are related to methylglyoxal reductases and may well have that activity as well.

Fetched 5 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 4 of these sequences

Found 1 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 341-344 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

A0A0E4AX59 carbonyl reductase (NADPH) (EC 1.1.1.184); methylglyoxal reductase (NADPH) (EC 1.1.1.283) from Kluyveromyces marxianus
PFams: 3Beta_HSD, Epimerase, GDP_Man_Dehyd, NAD_binding_4
344 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0E4AY21 carbonyl reductase (NADPH) (EC 1.1.1.184); methylglyoxal reductase (NADPH) (EC 1.1.1.283) from Kluyveromyces marxianus
PFams: 3Beta_HSD, Epimerase, GDP_Man_Dehyd
344 amino acids: PaperBLAST, CDD, Compare to cluster

Q12068 methylglyoxal reductase (EC 1.1.1.265; EC 1.1.1.283) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
GRE2_YEAST / Q12068 NADPH-dependent methylglyoxal reductase GRE2; 3-methylbutanal reductase; Genes de respuesta a estres protein 2; Isovaleraldehyde reductase; EC 1.1.1.283; EC 1.1.1.265 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Q12068 3-methylbutanal reductase (EC 1.1.1.265); methylglyoxal reductase (NADPH) (EC 1.1.1.283) from Saccharomyces cerevisiae
PFams: Epimerase, 3Beta_HSD
342 amino acids: PaperBLAST, CDD, Compare to cluster

GRP2_CANAL / P83775 Putative NADPH-dependent methylglyoxal reductase GRP2; Cytoplasmic antigenic protein 2; EC 1.1.1.283 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
CH_123670 potential oxidoreductase from Candida albicans
PFams: adh_short, Epimerase, Polysacc_synt_2, 3Beta_HSD, GDP_Man_Dehyd, NAD_binding_4, NAD_binding_10
341 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

O32210 glyoxal/methylglyoxal reductase (EC 1.1.1.283; EC 1.1.1.91) from Bacillus subtilis (strain 168)
GR_BACSU / O32210 Glyoxal reductase; GR; Methylglyoxal reductase; EC 1.1.1.-; EC 1.1.1.283 from Bacillus subtilis (strain 168)
PFams: Aldo_ket_red
276 amino acids: PaperBLAST, CDD