Clusters of Characterized Proteins

Clustering the characterized proteins for thuE (trehalose ABC transporter, substrate-binding component ThuE) in trehalose catabolism

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Definition of thuE

• Curated sequence G4FGN8: Extracellular solute-binding protein family 1, component of Trehalose porter. Also binds sucrose (Boucher and Noll, 2011). Induced by glucose and trehalose. Directly regulated by trehalose-responsive regulator TreR
• Curated sequence O51923: MalE aka PF1739, component of Maltose/trehalose porter
• Curated sequence Q72H68: Trehalose/maltose-binding protein aka TT_C1627, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose
• Curated sequence Q9R9Q7: ThuE aka RB0311 aka SMB20325, component of Trehalose/maltose/sucrose porter (trehalose inducible). ABC transporter for D-Trehalose, periplasmic substrate-binding component
• Curated sequence Q7LYW7: Trehalose/maltose-binding protein MalE; TMBP
• Comment: Systems similar to thuEFGK from Sinorhizobium meliloti are also found in Thermotoga maritima, Thermus thermophilus and Thermococcus litoralis. (The ATPase component in T. maritima is not described.) Mycobacterium tuberculosis has a similar system with a diverged SBP. A system similar to that from T. thermophilus, in Pyrococcus furiosus, also transports trehalose (PMC2685544).

Fetched 5 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 5 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 411-450 amino acids (4/5 heteromeric)

MALE_THELN / Q7LYW7 Trehalose/maltose-binding protein MalE; TMBP from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)
PFams: SBP_bac_1, SBP_bac_8
450 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.1.41 / G4FGN8 Extracellular solute-binding protein family 1, component of Trehalose porter. Also binds sucrose (Boucher and Noll, 2011). Induced by glucose and trehalose. Directly regulated by trehalose-responsive regulator TreR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
PFams: SBP_bac_1, SBP_bac_8
Heteromeric, 411 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.1.7 / O51923 MalE aka PF1739, component of Maltose/trehalose porter
PFams: SBP_bac_1, SBP_bac_8
Heteromeric, 450 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.1.25 / Q72H68 Trehalose/maltose-binding protein aka TT_C1627, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
PFams: SBP_bac_1, SBP_bac_8
Heteromeric, 429 amino acids: PaperBLAST, CDD, Compare to cluster

SM_b20325 ABC transporter for D-Trehalose, periplasmic substrate-binding component from Sinorhizobium meliloti 1021
TC 3.A.1.1.17 / Q9R9Q7 ThuE aka RB0311 aka SMB20325, component of Trehalose/maltose/sucrose porter (trehalose inducible) from Rhizobium meliloti (Sinorhizobium meliloti)
PFams: SBP_bac_1, SBP_bac_11, SBP_bac_8
Heteromeric, 423 amino acids: PaperBLAST, CDD, Compare to cluster