Clusters of Characterized Proteins

Clustering the characterized proteins for thuF (trehalose ABC transporter, permease component 1 (ThuF)) in trehalose catabolism

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Definition of thuF

• Curated sequence O51924: Trehalose/maltose transport system permease protein MalF
• Curated sequence P9WG03: Trehalose transport system permease protein SugA. PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGA, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence)
• Curated sequence G4FGN7: ABC-type transporter, integral membrane subunit, component of Trehalose porter. Also binds sucrose (Boucher and Noll, 2011). Induced by glucose and trehalose. Directly regulated by trehalose-responsive regulator TreR
• Curated sequence O51924: MalF, component of Maltose/trehalose porter
• Curated sequence Q72H67: Maltose transport system permease protein malF aka TT_C1628, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose
• Curated sequence SM_b20326: ABC transporter for D-Trehalose, permease component 1. ThuF aka RB0312 aka SMB20326, component of Trehalose/maltose/sucrose porter (trehalose inducible)
• Comment: (Removed Sulfolobus treT, which is related but is described separately)

Fetched 6 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 6 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 291-328 amino acids (5/6 heteromeric)

MALF_THELN / O51924 Trehalose/maltose transport system permease protein MalF from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)
PFams: BPD_transp_1
295 amino acids: PaperBLAST, CDD, Compare to cluster

SUGA_MYCTU / P9WG03 Trehalose transport system permease protein SugA from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
TC 3.A.1.1.31 / O50452 PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGA, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis
PFams: BPD_transp_1
Heteromeric, 307 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.1.41 / G4FGN7 ABC-type transporter, integral membrane subunit, component of Trehalose porter. Also binds sucrose (Boucher and Noll, 2011). Induced by glucose and trehalose. Directly regulated by trehalose-responsive regulator TreR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
PFams: BPD_transp_1
Heteromeric, 293 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.1.7 / O51924 MalF, component of Maltose/trehalose porter from Thermococcus litoralis
PFams: BPD_transp_1
Heteromeric, 300 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.1.25 / Q72H67 Maltose transport system permease protein malF aka TT_C1628, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
PFams: BPD_transp_1
Heteromeric, 291 amino acids: PaperBLAST, CDD, Compare to cluster

SM_b20326 ABC transporter for D-Trehalose, permease component 1 from Sinorhizobium meliloti 1021
TC 3.A.1.1.17 / Q9R9Q6 ThuF aka RB0312 aka SMB20326, component of Trehalose/maltose/sucrose porter (trehalose inducible) from Rhizobium meliloti (Sinorhizobium meliloti)
PFams: BPD_transp_1
Heteromeric, 328 amino acids: PaperBLAST, CDD, Compare to cluster