Clusters of Characterized Proteins

Clustering the characterized proteins for thuG (trehalose ABC transporter, permease component 2 (ThuG)) in trehalose catabolism

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Definition of thuG

• Curated sequence Q7LYX6: Trehalose/maltose transport system permease protein MalG. MalG aka PF1741, component of Maltose/trehalose porter
• Curated sequence P9WG01: Trehalose transport system permease protein SugB. PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGB, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence)
• Curated sequence G4FGN6: ABC-type transporter, integral membrane subunit, component of Trehalose porter. Also binds sucrose (Boucher and Noll, 2011). Induced by glucose and trehalose. Directly regulated by trehalose-responsive regulator TreR
• Curated sequence Q72H66: Maltose transport system permease protein malG aka TT_C1629, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose
• Curated sequence SM_b20327: ABC transporter for D-Trehalose, permease component 2. ThuG aka RB0313 aka SMB20327, component of Trehalose/maltose/sucrose porter (trehalose inducible)

Fetched 5 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 5 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 274-280 amino acids (heteromeric)

SUGB_MYCTU / P9WG01 Trehalose transport system permease protein SugB from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
TC 3.A.1.1.31 / O50453 PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGB, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis
PFams: BPD_transp_1
Heteromeric, 274 amino acids: PaperBLAST, CDD, Compare to cluster

MALG_THELN / Q7LYX6 Trehalose/maltose transport system permease protein MalG from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)
TC 3.A.1.1.7 / O51925 MalG aka PF1741, component of Maltose/trehalose porter
PFams: BPD_transp_1
Heteromeric, 278 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.1.41 / G4FGN6 ABC-type transporter, integral membrane subunit, component of Trehalose porter. Also binds sucrose (Boucher and Noll, 2011). Induced by glucose and trehalose. Directly regulated by trehalose-responsive regulator TreR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
PFams: BPD_transp_1
Heteromeric, 278 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.1.25 / Q72H66 Maltose transport system permease protein malG aka TT_C1629, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
PFams: BPD_transp_1
Heteromeric, 280 amino acids: PaperBLAST, CDD, Compare to cluster

SM_b20327 ABC transporter for D-Trehalose, permease component 2 from Sinorhizobium meliloti 1021
TC 3.A.1.1.17 / Q9R9Q5 ThuG aka RB0313 aka SMB20327, component of Trehalose/maltose/sucrose porter (trehalose inducible) from Rhizobium meliloti (Sinorhizobium meliloti)
PFams: BPD_transp_1
Heteromeric, 276 amino acids: PaperBLAST, CDD, Compare to cluster