Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for trpD_1 (glutamine amidotransferase of anthranilate synthase) in L-tryptophan biosynthesis

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Definition of trpD_1

HMM TIGR00566
Curated proteins matching anthranilate synthase component 2
Curated proteins matching anthranilate synthase component II
Curated proteins matching anthranilate synthase beta subunit
UniProt sequence Q8AAD4_BACTN: SubName: Full=Anthranilate synthase component II {ECO:0000313|EMBL:AAO75638.1};
UniProt sequence A0A1X9ZDE4_9SPHI: SubName: Full=Aminodeoxychorismate/anthranilate synthase component II {ECO:0000313|EMBL:ARS43103.1};
UniProt sequence Q72EV2_DESVH: SubName: Full=Anthranilate synthase, glutamine amidotransferase component {ECO:0000313|EMBL:AAS94949.1}; EC=4.1.3.27 {ECO:0000313|EMBL:AAS94949.1};
UniProt sequence B8DM46_DESVM: SubName: Full=Glutamine amidotransferase of anthranilate synthase {ECO:0000313|EMBL:ACL08690.1};
Ignore hits to items matching EC 4.1.3.27 when looking for 'other' hits
Ignore hits to items matching EC 2.6.1.85 when looking for 'other' hits
Comment: This component of anthranilate synthase is also known as the beta subunit or component II. Note that E. coli TrpD is this component fused to anthranilate phosphoribosyltransferase (which is described separately). Some proteins are components of both anthranilate synthase and 4-amino-4-deoxychorismate synthase (EC 2.6.1.85). Similarly, TIGR00566 also matches the amidotransferase component of para-aminobenzoate synthase. BT0531 (Q8AAD4_BACTN) and CA265_RS22895 (A0A1X9ZDE4_9SPHI) are also component II Similarly for DVU0466 (Q72EV2_DESVH) and DvMF_1745 (B8DM46_DESVM).

Fetched 16 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 15 of these sequences

Found 2 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 188-209 amino acids (7/12 heteromeric)

P09786 PhnB anthranilate synthase subunit (EC 4.1.3.27) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PHNB_PSEAE / P09786 Anthranilate synthase component 2, pyocyanine specific; AS; ASII; Anthranilate synthase beta subunit, pyocyanine specific; Anthranilate synthase, GATase component; Anthranilate synthase, glutamine amidotransferase component; EC 4.1.3.27 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
P09786 anthranilate synthase (subunit 1/2) (EC 4.1.3.27) from Pseudomonas aeruginosa
PFams: GATase, Peptidase_C26
Heteromeric, 200 amino acids: PaperBLAST, CDD, Compare to cluster

P20576 anthranilate synthase β subunit (EC 4.1.3.27) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
TRPG_PSEAE / P20576 Anthranilate synthase component 2; AS; ASII; Anthranilate synthase, GATase component; Anthranilate synthase, glutamine amidotransferase component; EC 4.1.3.27 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
P20576 anthranilate synthase (subunit 2/2) (EC 4.1.3.27) from Pseudomonas aeruginosa
PFams: GATase, Peptidase_C26
Heteromeric, 201 amino acids: PaperBLAST, CDD, Compare to cluster

Q06129 anthranilate synthase β subunit (EC 4.1.3.27) from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
TRPG_SACS2 / Q06129 Anthranilate synthase component 2; AS; ASII; Anthranilate synthase, GATase component; Anthranilate synthase, glutamine amidotransferase component; EC 4.1.3.27 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Q06129 anthranilate synthase (subunit 1/2) (EC 4.1.3.27) from Saccharolobus solfataricus
PFams: GATase, Peptidase_C26
Heteromeric, 195 amino acids: PaperBLAST, CDD, Compare to cluster

CH_008350 anthranilate synthase component II; EC 4.1.3.27 from Leptospira biflexa serovar Patoc
PFams: GATase, Peptidase_C26
201 amino acids: PaperBLAST, CDD, Compare to cluster

TRPG_SERMA / P00900 Anthranilate synthase component 2; AS; ASII; Anthranilate synthase, GATase component; Anthranilate synthase, glutamine amidotransferase component; EC 4.1.3.27 from Serratia marcescens
PFams: GATase, Peptidase_C26
Heteromeric, 193 amino acids: PaperBLAST, CDD, Compare to cluster

TRPG_PSEPU / P00901 Anthranilate synthase component 2; AS; ASII; Anthranilate synthase, GATase component; Anthranilate synthase, glutamine amidotransferase component; EC 4.1.3.27 from Pseudomonas putida (Arthrobacter siderocapsulatus)
PFams: GATase, Peptidase_C26
Heteromeric, 198 amino acids: PaperBLAST, CDD, Compare to cluster

TRPG_AZOBR / P26922 Anthranilate synthase component 2; AS; ASII; Anthranilate synthase, GATase component; Anthranilate synthase, glutamine amidotransferase component; EC 4.1.3.27 from Azospirillum brasilense
PFams: GATase, Peptidase_C26
Heteromeric, 196 amino acids: PaperBLAST, CDD, Compare to cluster

P28819 4-amino-4-deoxychorismate synthase; anthranilate synthase (subunit II) (EC 2.6.1.123) from Bacillus subtilis (strain 168)
PABA_BACSU / P28819 Aminodeoxychorismate/anthranilate synthase component 2; ADC synthase; ADCS; 4-amino-4-deoxychorismate synthase component 2; Aminodeoxychorismate synthase, glutamine amidotransferase component; EC 2.6.1.85; EC 4.1.3.27 from Bacillus subtilis (strain 168)
PFams: GATase, Peptidase_C26
Heteromeric, 194 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1X9ZDE4_9SPHI Aminodeoxychorismate/anthranilate synthase component II
198 amino acids: PaperBLAST, CDD, Compare to cluster

B8DM46_DESVM Glutamine amidotransferase of anthranilate synthase
192 amino acids: PaperBLAST, CDD, Compare to cluster

Q72EV2_DESVH Anthranilate synthase, glutamine amidotransferase component; EC=4.1.3.27
209 amino acids: PaperBLAST, CDD, Compare to cluster

Q8AAD4_BACTN Anthranilate synthase component II
188 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 273-288 amino acids (heteromeric)

ASB1_ORYSJ / Q7XUS2 Anthranilate synthase beta subunit 1, chloroplastic; OsASB1; Anthranilate synthase, glutamine amidotransferase component 2-1; EC 4.1.3.27 from Oryza sativa subsp. japonica (Rice)
PFams: GATase, Peptidase_C26
Heteromeric, 288 amino acids: PaperBLAST, CDD, Compare to cluster

ASB1_ARATH / Q42565 Anthranilate synthase beta subunit 1, chloroplastic; Anthranilate synthase component 2-1; Anthranilate synthase, glutamine amidotransferase component 2-1; Protein TRYPTOPHAN BIOSYNTHESIS 4; Protein WEAK ETHYLENE INSENSITIVE 7; EC 4.1.3.27 from Arabidopsis thaliana (Mouse-ear cress)
PFams: GATase, Peptidase_C26
Heteromeric, 276 amino acids: PaperBLAST, CDD, Compare to cluster

ASB2_ORYSJ / Q764B9 Anthranilate synthase beta subunit 2, chloroplastic; OsASB2; Anthranilate synthase, glutamine amidotransferase component 2-2; EC 4.1.3.27 from Oryza sativa subsp. japonica (Rice)
PFams: GATase, Peptidase_C26
Heteromeric, 273 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

CH_122586 anthranilate synthase component 2; EC 4.1.3.27 from Emericella nidulans
PFams: GATase, IGPS, PRAI
768 amino acids: PaperBLAST, CDD