GapMind for Amino acid biosynthesis

 

Clusters of Characterized Proteins

Clustering the characterized proteins for trpD_2 (anthranilate phosphoribosyltransferase) in L-tryptophan biosynthesis

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Definition of trpD_2

Fetched 11 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 11 of these sequences

Found 2 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 325-370 amino acids (not heteromeric)

TRPD_MYCTU / P9WFX5 Anthranilate phosphoribosyltransferase; EC 2.4.2.18 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
A5U4M0 anthranilate phosphoribosyltransferase (EC 2.4.2.18) from Mycobacterium tuberculosis
P9WFX5 anthranilate phosphoribosyltransferase (EC 2.4.2.18) from Mycobacterium tuberculosis
PFams: Glycos_trans_3N, Glycos_transf_3
370 amino acids: PaperBLAST, CDD, Compare to cluster

TRPD_SACS2 / P50384 Anthranilate phosphoribosyltransferase; EC 2.4.2.18 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
P50384 anthranilate phosphoribosyltransferase (EC 2.4.2.18) from Saccharolobus solfataricus
PFams: Glycos_trans_3N, Glycos_transf_3
345 amino acids: PaperBLAST, CDD, Compare to cluster

Q9YGB4 anthranilate phosphoribosyltransferase (EC 2.4.2.18) from Thermococcus kodakarensis
PFams: Glycos_trans_3N, Glycos_transf_3
325 amino acids: PaperBLAST, CDD, Compare to cluster

TRPD_THETH / P83827 Anthranilate phosphoribosyltransferase; EC 2.4.2.18 from Thermus thermophilus
TRPD_THET8 / Q5SH88 Anthranilate phosphoribosyltransferase; EC 2.4.2.18 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
PFams: Glycos_trans_3N, Glycos_transf_3
329 amino acids: PaperBLAST, CDD, Compare to cluster

TRPD_XANCP / Q8PD71 Anthranilate phosphoribosyltransferase; EC 2.4.2.18 from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
PFams: Glycos_trans_3N, Glycos_transf_3
345 amino acids: PaperBLAST, CDD, Compare to cluster

TRPD2_NOSS1 / Q8YXQ9 Anthranilate phosphoribosyltransferase 2; EC 2.4.2.18 from Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
PFams: Glycos_trans_3N, Glycos_transf_3
362 amino acids: PaperBLAST, CDD, Compare to cluster

BT0530 anthranilate phosphoribosyltransferase (EC 2.4.2.18) from Bacteroides thetaiotaomicron VPI-5482
PFams: Glycos_trans_3N, Glycos_transf_3
332 amino acids: PaperBLAST, CDD, Compare to cluster

CA265_RS05010 anthranilate phosphoribosyltransferase (EC 2.4.2.18) from Pedobacter sp. GW460-11-11-14-LB5
PFams: Glycos_trans_3N, Glycos_transf_3
329 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 531-531 amino acids (1/2 heteromeric)

b1263 anthranilate synthase subunit TrpD (EC 2.4.2.18; EC 4.1.3.27) from Escherichia coli K-12 substr. MG1655
P00904 anthranilate synthase subunit TrpD (EC 2.4.2.18) from Escherichia coli (strain K12)
TRPGD_ECOLI / P00904 Bifunctional protein TrpGD; EC 4.1.3.27; EC 2.4.2.18 from Escherichia coli (strain K12)
PFams: GATase, Peptidase_C26, Glycos_trans_3N, Glycos_transf_3
Heteromeric, 531 amino acids: PaperBLAST, CDD, Compare to cluster

TRPGD_SALTY / P00905 Bifunctional protein TrpGD; EC 4.1.3.27; EC 2.4.2.18 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PFams: GATase, Peptidase_C26, Glycos_trans_3N, Glycos_transf_3
531 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

TRPD_YEAST / P07285 Anthranilate phosphoribosyltransferase; PRtransferase; EC 2.4.2.18 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: Glycos_transf_3
380 amino acids: PaperBLAST, CDD
(similar to BRENDA::P50384 from Cluster 1, but similarity to seed sequence is below thresholds)