Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for trpE (anthranilate synthase subunit TrpE) in L-tryptophan biosynthesis

Or see other characterized proteins similar to trpE

Or see all steps for L-tryptophan biosynthesis

Or cluster curated proteins matching a keyword

Definition of trpE

HMM TIGR00564
HMM TIGR00565
HMM TIGR01820
Curated proteins matching anthranilate synthase component 1
Curated proteins matching anthranilate synthase component I
Curated proteins matching anthranilate synthase alpha subunit
UniProt sequence Q8AAD3_BACTN: SubName: Full=Anthranilate synthase component I {ECO:0000313|EMBL:AAO75639.1};
UniProt sequence A0A1X9ZB07_9SPHI: SubName: Full=Anthranilate synthase component I {ECO:0000313|EMBL:ARS42349.1};
UniProt sequence Q72EV3_DESVH: SubName: Full=Anthranilate synthase, component I {ECO:0000313|EMBL:AAS94948.1};
UniProt sequence B8DM47_DESVM: SubName: Full=Anthranilate synthase {ECO:0000313|EMBL:ACL08691.1}; EC=4.1.3.27 {ECO:0000313|EMBL:ACL08691.1};
Ignore hits to items matching EC 4.1.3.27 when looking for 'other' hits
Comment: This component of anthranilate synthase is also known as the alpha subunit or component I. BT0532 (Q8AAD3_BACTN) and CA265_RS22890 (A0A1X9ZB07_9SPHI) are also component I. Similarly for DVU0465 (Q72EV3_DESVH) and DvMF_1746 (B8DM47_DESVM). Some related proteins have EC 2.6.1.85 which should perhaps be ignored.

Fetched 17 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 17 of these sequences

Found 1 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 421-606 amino acids (8/16 heteromeric)

The first sequence in each cluster is the seed.

TRPE_PSEPU / P20579 Anthranilate synthase component 1; AS; ASI; EC 4.1.3.27 from Pseudomonas putida (Arthrobacter siderocapsulatus)
PFams: Anth_synt_I_N, Chorismate_bind
Heteromeric, 493 amino acids: PaperBLAST, CDD, Compare to cluster

TRPE_SERMA / P00897 Anthranilate synthase component 1; AS; ASI; EC 4.1.3.27 from Serratia marcescens
P00897 anthranilate synthase (subunit 2/2) (EC 4.1.3.27) from Serratia marcescens
PFams: Anth_synt_I_N, Chorismate_bind
Heteromeric, 519 amino acids: PaperBLAST, CDD, Compare to cluster

P20580 anthranilate synthase α subunit (EC 4.1.3.27) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
TRPE_PSEAE / P20580 Anthranilate synthase component 1; AS; ASI; EC 4.1.3.27 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
P20580 anthranilate synthase (subunit 1/2) (EC 4.1.3.27) from Pseudomonas aeruginosa
PFams: Anth_synt_I_N, Chorismate_bind
Heteromeric, 492 amino acids: PaperBLAST, CDD, Compare to cluster

Q06128 anthranilate synthase α subunit (EC 4.1.3.27) from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
TRPE_SACS2 / Q06128 Anthranilate synthase component 1; AS; ASI; EC 4.1.3.27 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Q06128 anthranilate synthase (subunit 2/2) (EC 4.1.3.27) from Saccharolobus solfataricus
PFams: Anth_synt_I_N, Chorismate_bind
Heteromeric, 421 amino acids: PaperBLAST, CDD, Compare to cluster

CH_008302 anthranilate synthase component I; EC 4.1.3.27 from Leptospira biflexa serovar Patoc
PFams: Anth_synt_I_N, Chorismate_bind
462 amino acids: PaperBLAST, CDD, Compare to cluster

b1264 anthranilate synthase subunit TrpE (EC 4.1.3.27) from Escherichia coli K-12 substr. MG1655
P00895 anthranilate synthase subunit TrpE (EC 4.1.3.27) from Escherichia coli (strain K12)
TRPE_ECOLI / P00895 Anthranilate synthase component 1; AS; ASI; EC 4.1.3.27 from Escherichia coli (strain K12)
PFams: Anth_synt_I_N, Chorismate_bind
Heteromeric, 520 amino acids: PaperBLAST, CDD, Compare to cluster

TRPE_SALTY / P00898 Anthranilate synthase component 1; AS; ASI; EC 4.1.3.27 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PFams: Anth_synt_I_N, Chorismate_bind
520 amino acids: PaperBLAST, CDD, Compare to cluster

TRPE_YEAST / P00899 Anthranilate synthase component 1; Anthranilate synthase component I; EC 4.1.3.27 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: Anth_synt_I_N, Chorismate_bind
507 amino acids: PaperBLAST, CDD, Compare to cluster

TRPE_ARATH / P32068 Anthranilate synthase alpha subunit 1, chloroplastic; Anthranilate synthase component 1-1; Anthranilate synthase component I-1; Protein A-METHYL TRYPTOPHAN RESISTANT 1; Protein JASMONATE-INDUCED DEFECTIVE LATERAL ROOT 1; Protein TRYPTOPHAN BIOSYNTHESIS 5; Protein WEAK ETHYLENE INSENSITIVE 2; EC 4.1.3.27 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Anth_synt_I_N, Chorismate_bind
Heteromeric, 595 amino acids: PaperBLAST, CDD, Compare to cluster

ASA1_ORYSJ / Q94GF1 Anthranilate synthase alpha subunit 1, chloroplastic; OsASA1; EC 4.1.3.27 from Oryza sativa subsp. japonica (Rice)
PFams: Anth_synt_I_N, Chorismate_bind
Heteromeric, 577 amino acids: PaperBLAST, CDD, Compare to cluster

ASA2_ORYSJ / Q9XJ29 Anthranilate synthase alpha subunit 2, chloroplastic; OsASA2; EC 4.1.3.27 from Oryza sativa subsp. japonica (Rice)
PFams: Anth_synt_I_N, Chorismate_bind
Heteromeric, 606 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1X9ZB07_9SPHI Anthranilate synthase component I
466 amino acids: PaperBLAST, CDD, Compare to cluster

B8DM47_DESVM Anthranilate synthase; EC=4.1.3.27
520 amino acids: PaperBLAST, CDD, Compare to cluster

Q72EV3_DESVH Anthranilate synthase, component I
532 amino acids: PaperBLAST, CDD, Compare to cluster

Q8AAD3_BACTN Anthranilate synthase component I
468 amino acids: PaperBLAST, CDD, Compare to cluster

Q08653 anthranilate synthase component I (EC 4.1.3.27) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
PFams: Anth_synt_I_N, Chorismate_bind
461 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (1/1 heteromeric)

P09785 PhnA anthranilate synthase subunit (EC 4.1.3.27) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PHNA_PSEAE / P09785 Anthranilate synthase component 1, pyocyanine specific; AS; ASI; Anthranilate synthase alpha subunit, pyocyanine specific; EC 4.1.3.27 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
P09785 anthranilate synthase (subunit 2/2) (EC 4.1.3.27) from Pseudomonas aeruginosa
PFams: Anth_synt_I_N, Chorismate_bind
Heteromeric, 530 amino acids: PaperBLAST, CDD
(similar to BRENDA::P00897 from Cluster 1, but similarity to seed sequence is below thresholds)