Clusters of Characterized Proteins

Clustering the characterized proteins for aroP (tryptophan:H+ symporter AroP) in L-tryptophan catabolism

Or see other characterized proteins similar to aroP

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Definition of aroP

• Curated sequence P15993: Aromatic amino acid:H+ symporter, AroP of 457 aas and 12 TMSs (Cosgriff and Pittard 1997). Transports phenylalanine, tyrosine and tryptophan. aromatic amino acid:H⁺ symporter AroP. aromatic amino acid:H⁺ symporter AroP
• Curated sequence F2HN33: Transporter for phenylalainine, tyrosine and tryptophan of 449 aas and 12 TMSs, FywP or YsjA
• Curated sequence Q2VQZ4: Arbuscular mycorrhizal fungal proline:H+ symporter, AAP1 (binds and probably transports nonpolar, hydrophobic amino acids)
• Curated sequence Q46065: Aromatic amino acid permease, AroP
• UniProt sequence A0A0N9WG97: SubName: Full=Amino acid permease {ECO:0000313|EMBL:ALI00611.1};
• UniProt sequence Q4KIP0: SubName: Full=Aromatic amino acid transport protein AroP {ECO:0000313|EMBL:AAY96158.1};
• Ignore hits to A2RMP5 when looking for 'other' hits (Aromatic amino acid permease FywP)
• Ignore hits to AO356_18530 when looking for 'other' hits (L-tyrosine transporter)
• Comment: AO353_05930 (A0A0N9WG97) from Pseudomonas fluorescens FW300-N2E3 is related to aroP and is specifically improtant for tryptophan utilization (although more so if Trp is the nitrogen source). PfGW456L13_4291 (A0A293QSB2) from P. fluorescens GW4560-L13 is related to aroP and is specifically important for tryptophan utilization. Unfortunately A0A293QSB2 is no longer in UniProt; the closest remaining sequence is Q4KIP0 (only 87% identical). FywP (A2RMP5) may well be a tryptophan transporter as well, so ignore.

Fetched 6 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 6 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 449-536 amino acids (not heteromeric)

b0112 aromatic amino acid:H⁺ symporter AroP from Escherichia coli K-12 substr. MG1655
P15993 aromatic amino acid:H⁺ symporter AroP from Escherichia coli (strain K12)
TC 2.A.3.1.3 / P15993 Aromatic amino acid:H+ symporter, AroP of 457 aas and 12 TMSs (Cosgriff and Pittard 1997). Transports phenylalanine, tyrosine and tryptophan from Escherichia coli
PFams: AA_permease, AA_permease_2
457 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.3.1.22 / F2HN33 Transporter for phenylalainine, tyrosine and tryptophan of 449 aas and 12 TMSs, FywP or YsjA from Lactococcus lactis subsp. lactis (strain CV56)
PFams: AA_permease_2, AA_permease
449 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.3.10.22 / Q2VQZ4 Arbuscular mycorrhizal fungal proline:H+ symporter, AAP1 (binds and probably transports nonpolar, hydrophobic amino acids) from Glomus mosseae
PFams: AA_permease, AA_permease_2
536 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.3.1.12 / Q46065 Aromatic amino acid permease, AroP from Corynebacterium glutamicum (Brevibacterium flavum)
PFams: AA_permease_2, Spore_permease, AA_permease
463 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0N9WG97 Amino acid permease
470 amino acids: PaperBLAST, CDD, Compare to cluster

Q4KIP0 Aromatic amino acid transport protein AroP
466 amino acids: PaperBLAST, CDD, Compare to cluster