GapMind for catabolism of small carbon sources

 

Clusters of Characterized Proteins

Clustering the characterized proteins for mhpE (4-hydroxy-2-oxovalerate aldolase) in L-tryptophan catabolism

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Definition of mhpE

Fetched 13 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 13 of these sequences

Found 2 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 337-352 amino acids (2/11 heteromeric)

HOA4_PARXL / P51015 4-hydroxy-2-oxovalerate aldolase 4; HOA 4; 4-hydroxy-2-keto-pentanoic acid aldolase 4; 4-hydroxy-2-oxohexanoate aldolase; 4-hydroxy-2-oxopentanoate aldolase 4; EC 4.1.3.39; EC 4.1.3.43 from Paraburkholderia xenovorans (strain LB400)
P51015 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39); 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) from Paraburkholderia xenovorans LB400
GB|ABE37049.1 4-hydroxy-2-oxovalerate aldolase; EC 4.1.3.39 from Burkholderia xenovorans LB400
PFams: HMGL-like, DmpG_comm
Heteromeric, 346 amino acids: PaperBLAST, CDD, Compare to cluster

P51016 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas sp. (strain CF600)
HOA_PSEUF / P51016 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39 from Pseudomonas sp. (strain CF600)
P51016 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas sp.
PFams: HMGL-like, DmpG_comm
Heteromeric, 345 amino acids: PaperBLAST, CDD, Compare to cluster

P51017 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas putida
PFams: HMGL-like, DmpG_comm
346 amino acids: PaperBLAST, CDD, Compare to cluster

P9WMK5 4-hydroxy-2-oxohexanoate aldolase monomer (EC 4.1.3.43) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WMK5 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Mycobacterium tuberculosis
PFams: HMGL-like, DmpG_comm
346 amino acids: PaperBLAST, CDD, Compare to cluster

HOA_THET8 / Q53WI0 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxohexanoate aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39; EC 4.1.3.43 from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Q53WI0 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) from Thermus thermophilus
PFams: HMGL-like, DmpG_comm
347 amino acids: PaperBLAST, CDD, Compare to cluster

b0352 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Escherichia coli K-12 substr. MG1655
P51020 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Escherichia coli (strain K12)
HOA_ECOLI / P51020 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39 from Escherichia coli (strain K12)
GB|BAA13057.1 4-hydroxy-2-oxovalerate aldolase; EC 4.1.3.39 from Escherichia coli K12
PFams: HMGL-like, DmpG_comm
337 amino acids: PaperBLAST, CDD, Compare to cluster

HOA_PSESP / Q9KWS0 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39 from Pseudomonas sp.
PFams: HMGL-like, DmpG_comm
343 amino acids: PaperBLAST, CDD, Compare to cluster

P51018 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)
PFams: HMGL-like, DmpG_comm
352 amino acids: PaperBLAST, CDD, Compare to cluster

Q0S815 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) (from HMM only) from Rhodococcus jostii (strain RHA1)
PFams: HMGL-like, DmpG_comm
339 amino acids: PaperBLAST, CDD, Compare to cluster

Q83VZ3 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) (from HMM only) from Comamonas testosteroni
PFams: HMGL-like, DmpG_comm
350 amino acids: PaperBLAST, CDD, Compare to cluster

P51019 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas putida
PFams: HMGL-like, DmpG_comm
345 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 258-262 amino acids (not heteromeric)

BPHF_RHOJR / O05151 4-hydroxy-2-oxovalerate aldolase; HOA; EC 4.1.3.39 from Rhodococcus jostii (strain RHA1)
PFams: HpcH_HpaI
258 amino acids: PaperBLAST, CDD, Compare to cluster

HPCH_ECOLX / Q47098 4-hydroxy-2-oxo-heptane-1,7-dioate aldolase; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; HHED aldolase; 4-hydroxy-2-ketoheptane-1,7-dioate aldolase; HKHD aldolase; EC 4.1.2.52 from Escherichia coli
B1IS70 4-hydroxy-2-oxoheptanedioate aldolase (EC 4.1.2.52) from Escherichia coli
Q47098 4-hydroxy-2-oxoheptanedioate aldolase (EC 4.1.2.52); 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Escherichia coli
PFams: HpcH_HpaI
262 amino acids: PaperBLAST, CDD, Compare to cluster