Clusters of Characterized Proteins

Clustering the characterized proteins for praB (2-hydroxymuconate 6-semialdehyde dehydrogenase) in L-tryptophan catabolism

Or see other characterized proteins similar to praB

Or see all steps for L-tryptophan catabolism

Or cluster curated proteins matching a keyword

Definition of praB

• Curated proteins or TIGRFams with EC 1.2.1.85
• Curated proteins or TIGRFams with EC 1.2.1.32
• Comment: EC 1.2.1.32 is 2-aminomuconate 6-semialdehyde dehydrogenase, but it is also reported to act on 2-hydroxymuconate-6-semialdehyde; many of these proteins are very similar to EC 1.2.1.85

Fetched 10 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 9 of these sequences

Found 1 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 485-500 amino acids (not heteromeric)

Q1XGK8 2-hydroxymuconate-6-semialdehyde dehydrogenase (EC 1.2.1.85) from Pseudomonas putida
PFams: Aldedh
486 amino acids: PaperBLAST, CDD, Compare to cluster

Q83XU8 aminomuconate-semialdehyde dehydrogenase (EC 1.2.1.32) from Burkholderia cepacia
PFams: Aldedh
485 amino acids: PaperBLAST, CDD, Compare to cluster

AL8A1_MOUSE / Q8BH00 2-aminomuconic semialdehyde dehydrogenase; Aldehyde dehydrogenase family 8 member A1; Retinal dehydrogenase 4; EC 1.2.1.32 from Mus musculus (Mouse)
Q8BH00 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Mus musculus
PFams: Aldedh
487 amino acids: PaperBLAST, CDD, Compare to cluster

P23105 2-hydroxymuconate semialdehyde dehydrogenase subunit (EC 1.2.1.85) from Pseudomonas putida
XYLG_PSEPU / P23105 2-hydroxymuconic semialdehyde dehydrogenase; HMSD; EC 1.2.1.85 from Pseudomonas putida (Arthrobacter siderocapsulatus)
PFams: Aldedh
486 amino acids: PaperBLAST, CDD, Compare to cluster

AL8A1_HUMAN / Q9H2A2 2-aminomuconic semialdehyde dehydrogenase; Aldehyde dehydrogenase 12; Aldehyde dehydrogenase family 8 member A1; EC 1.2.1.32 from Homo sapiens (Human)
Q9H2A2 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Homo sapiens
PFams: Aldedh
487 amino acids: PaperBLAST, CDD, Compare to cluster

Q9KWS5 2-aminomuconic 6-semialdehyde dehydrogenase monomer (EC 1.2.1.32) from Pseudomonas sp.
AMNC_PSESP / Q9KWS5 2-aminomuconic 6-semialdehyde dehydrogenase; Aminomuconate-semialdehyde dehydrogenase; EC 1.2.1.32 from Pseudomonas sp.
PFams: Aldedh
491 amino acids: PaperBLAST, CDD, Compare to cluster

Q38M39 2-aminomuconate semialdehyde dehydrogenase (EC 1.2.1.32) from Comamonas testosteroni CNB-1
PFams: Aldedh
490 amino acids: PaperBLAST, CDD, Compare to cluster

Q83V33 2-aminomuconate 6-semialdehyde dehydrogenase (EC 1.2.1.32) from Pseudomonas fluorescens
Q83V33 aminomuconate-semialdehyde dehydrogenase (EC 1.2.1.32) from Pseudomonas fluorescens
PFams: Aldedh
500 amino acids: PaperBLAST, CDD, Compare to cluster

C4TP02 2-hydroxymuconate-6-semialdehyde dehydrogenase (EC 1.2.1.85) from Paenibacillus sp. JJ-1b
PFams: Aldedh
486 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

O68391 2-aminomucoate semialdehyde dehydrogenase subunit (EC 1.2.1.32) from Pseudomonas oleovorans
PFams: Aldedh
542 amino acids: PaperBLAST, CDD