GapMind for Amino acid biosynthesis

 

Clusters of Characterized Proteins

Clustering the characterized proteins for PAH (phenylalanine hydroxylase) in L-tyrosine biosynthesis

Or see other characterized proteins similar to PAH

Or see all steps for L-tyrosine biosynthesis

Or cluster curated proteins matching a keyword

Definition of PAH

Fetched 16 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 16 of these sequences

Found 3 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 261-297 amino acids (not heteromeric)

Ac3H11_1847 Phenylalanine 4-monooxygenase (EC 1.14.16.1) from Acidovorax sp. GW101-3H11
PFams: Biopterin_H
290 amino acids: PaperBLAST, CDD, Compare to cluster

P30967 phenylalanine hydroxylase (EC 1.14.16.1) from Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
P30967 phenylalanine 4-monooxygenase (EC 1.14.16.1) from Chromobacterium violaceum
PFams: Biopterin_H
297 amino acids: PaperBLAST, CDD, Compare to cluster

Q47XN7 phenylalanine 4-monooxygenase (EC 1.14.16.1) from Colwellia psychrerythraea
PFams: Biopterin_H
267 amino acids: PaperBLAST, CDD, Compare to cluster

SO1666 Phenylalanine 4-monooxygenase (EC 1.14.16.1) from Shewanella oneidensis MR-1
PFams: Biopterin_H
271 amino acids: PaperBLAST, CDD, Compare to cluster

PfGW456L13_4394 Phenylalanine 4-monooxygenase (EC 1.14.16.1) from Pseudomonas fluorescens GW456-L13
PFams: Biopterin_H
261 amino acids: PaperBLAST, CDD, Compare to cluster

AO353_18585 Phenylalanine 4-monooxygenase (EC 1.14.16.1) from Pseudomonas fluorescens FW300-N2E3
PFams: Biopterin_H
263 amino acids: PaperBLAST, CDD, Compare to cluster

AO356_03975 Phenylalanine 4-monooxygenase (EC 1.14.16.1) from Pseudomonas fluorescens FW300-N2C3
PFams: Biopterin_H
261 amino acids: PaperBLAST, CDD, Compare to cluster

Pf6N2E2_2630 Phenylalanine 4-monooxygenase (EC 1.14.16.1) from Pseudomonas fluorescens FW300-N2E2
PFams: Biopterin_H
261 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 441-457 amino acids (not heteromeric)

P00439 phenylalanine hydroxylase subunit (EC 1.14.16.1) from Homo sapiens
PH4H_HUMAN / P00439 Phenylalanine-4-hydroxylase; PAH; Phe-4-monooxygenase; EC 1.14.16.1 from Homo sapiens (Human)
P00439 phenylalanine 4-monooxygenase (EC 1.14.16.1) from Homo sapiens
PFams: ACT, Biopterin_H
452 amino acids: PaperBLAST, CDD, Compare to cluster

PH4H_RAT / P04176 Phenylalanine-4-hydroxylase; PAH; Phe-4-monooxygenase; EC 1.14.16.1 from Rattus norvegicus (Rat)
P04176 phenylalanine 4-monooxygenase (EC 1.14.16.1) from Rattus norvegicus
PFams: ACT, Biopterin_H
453 amino acids: PaperBLAST, CDD, Compare to cluster

Q8TEY0 phenylalanine 4-monooxygenase (EC 1.14.16.1) from Homo sapiens
PFams: ACT, Biopterin_H
452 amino acids: PaperBLAST, CDD, Compare to cluster

PH4H_CAEEL / P90925 Phenylalanine-4-hydroxylase; PAH; Biogenic amine synthesis protein 2; Phe-4-monooxygenase; Tryptophan 5-monooxygenase; EC 1.14.16.1; EC 1.14.16.4 from Caenorhabditis elegans
PFams: ACT, Biopterin_H
457 amino acids: PaperBLAST, CDD, Compare to cluster

PH4H_DICDI / Q54XS1 Phenylalanine-4-hydroxylase; PAH; Phe-4-monooxygenase; Tryptophan 5-hydroxylase; TRH; Tryptophan 5-monooxygenase; EC 1.14.16.1; EC 1.14.16.4 from Dictyostelium discoideum (Social amoeba)
PFams: Biopterin_H
441 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 354-394 amino acids (not heteromeric)

PH4H_PINTA / E5KBU3 Phenylalanine 4-monooxygenase, chloroplastic; Aromatic amino acid hydroxylase; Phenylalanine 4-hydroxylase; EC 1.14.16.1 from Pinus taeda (Loblolly pine)
PFams: Biopterin_H
354 amino acids: PaperBLAST, CDD, Compare to cluster

A8HQD7 phenylalanine hydroxylase (EC 1.14.16.1) from Chlamydomonas reinhardtii
PH4H_CHLRE / A8HQD7 Phenylalanine 4-monooxygenase, chloroplastic; Aromatic amino acid hydroxylase; Phenylalanine 4-hydroxylase; EC 1.14.16.1 from Chlamydomonas reinhardtii (Chlamydomonas smithii)
PFams: Biopterin_H
361 amino acids: PaperBLAST, CDD, Compare to cluster

E5KBU4 phenylalanine hydroxylase (EC 1.14.16.1) from Physcomitrium patens
PH4H_PHYPA / E5KBU4 Phenylalanine 4-monooxygenase, chloroplastic; Aromatic amino acid hydroxylase; Phenylalanine 4-hydroxylase; EC 1.14.16.1 from Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens)
PFams: Biopterin_H
394 amino acids: PaperBLAST, CDD, Compare to cluster