Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for cmutase (chorismate mutase) in L-tyrosine biosynthesis

Or see other characterized proteins similar to cmutase

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Definition of cmutase

Curated proteins or TIGRFams with EC 5.4.99.5
HMM PF01817
Curated sequence P43902: prephenate dehydrogenase (EC 1.3.1.12)
Curated sequence Q74NC4: prephenate dehydratase (EC 4.2.1.51)
Curated sequence A8AAX2: prephenate dehydrogenase (NADP+) (EC 1.3.1.13)
Comment: Chorismate mutase is usually fused to prephenate dehydratase, which makes it difficult to find this activity when it is fused to something else, so we included the entire pfam in the step's definition. The only other function for this family that we are aware of is 4-amino-4-deoxychorismate mutase, which is involved in the biosynthesis of some antibiotics. (Proteins that are similar to 4-amino-4-deoxychorismate mutases will be marked as medium-confidence in the results.) Several fusion proteins are missing this EC number in their annotations (P43902, Q74NC4, A8AAX2)

Fetched 49 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 41 of these sequences

Found 10 clusters of similar sequences. Another 8 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 253-340 amino acids (not heteromeric)

A0A2K1JMA3 chorismate mutase (EC 5.4.99.5) from Physcomitrium patens
297 amino acids: PaperBLAST, CDD, Compare to cluster

A9S498 chorismate mutase (EC 5.4.99.5) from Physcomitrium patens
316 amino acids: PaperBLAST, CDD, Compare to cluster

D8R1Y1 chorismate mutase (EC 5.4.99.5) from Selaginella moellendorffii
267 amino acids: PaperBLAST, CDD, Compare to cluster

P42738 chorismate mutase (EC 5.4.99.5) from Arabidopsis thaliana
CM1_ARATH / P42738 Chorismate mutase 1, chloroplastic; AtCM1; CM-1; EC 5.4.99.5 from Arabidopsis thaliana (Mouse-ear cress)
P42738 chorismate mutase (EC 5.4.99.5) from Arabidopsis thaliana
340 amino acids: PaperBLAST, CDD, Compare to cluster

Q9C544 chorismate mutase (EC 5.4.99.5) from Arabidopsis thaliana
CM3_ARATH / Q9C544 Chorismate mutase 3, chloroplastic; AtCM3; CM-3; EC 5.4.99.5 from Arabidopsis thaliana (Mouse-ear cress)
Q9C544 chorismate mutase (EC 5.4.99.5) from Arabidopsis thaliana
316 amino acids: PaperBLAST, CDD, Compare to cluster

Q9S7H4 chorismate mutase (EC 5.4.99.5) from Arabidopsis thaliana
CM2_ARATH / Q9S7H4 Chorismate mutase 2; AtCM2; CM-2; EC 5.4.99.5 from Arabidopsis thaliana (Mouse-ear cress)
Q9S7H4 chorismate mutase (EC 5.4.99.5) from Arabidopsis thaliana
265 amino acids: PaperBLAST, CDD, Compare to cluster

U5D896 chorismate mutase (EC 5.4.99.5) from Amborella trichopoda
292 amino acids: PaperBLAST, CDD, Compare to cluster

W1PFX5 chorismate mutase (EC 5.4.99.5) from Amborella trichopoda
328 amino acids: PaperBLAST, CDD, Compare to cluster

CHMU_TRIPA / A0A0S0FTT9 Chorismate mutase; CM; TpARO7; EC 5.4.99.5 from Trichoderma parareesei (Filamentous fungus)
A0A0S0FTT9 chorismate mutase (EC 5.4.99.5) from Trichoderma parareesei
266 amino acids: PaperBLAST, CDD, Compare to cluster

CMU_ERYQU / A0A5B8NIM2 Chorismate mutase; EqCMU; EC 5.4.99.5 from Erysiphe quercicola (Hevea powdery mildew)
262 amino acids: PaperBLAST, CDD, Compare to cluster

CM1_MAIZE / B4FNK8 Chorismate mutase 1, chloroplastic; ZmCM1; EC 5.4.99.5 from Zea mays (Maize)
312 amino acids: PaperBLAST, CDD, Compare to cluster

CM2_MAIZE / B4FUP5 Chorismate mutase 2, cytosolic; ZmCM2; EC 5.4.99.5 from Zea mays (Maize)
253 amino acids: PaperBLAST, CDD, Compare to cluster

CM1_PETHY / D2CSU4 Chorismate mutase 1, chloroplastic; PhCM1; EC 5.4.99.5 from Petunia hybrida (Petunia)
D2CSU4 chorismate mutase (EC 5.4.99.5) from Petunia x hybrida
324 amino acids: PaperBLAST, CDD, Compare to cluster

CM2_PETHY / D2CSU5 Chorismate mutase 2; PhCM2; EC 5.4.99.5 from Petunia hybrida (Petunia)
D2CSU5 chorismate mutase (EC 5.4.99.5) from Petunia x hybrida
263 amino acids: PaperBLAST, CDD, Compare to cluster

CHMU_EMENI / G5EB37 Chorismate mutase; CM; AnCM; EC 5.4.99.5 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
CH_122283 chorismate mutase; EC 5.4.99.5 from Emericella nidulans
267 amino acids: PaperBLAST, CDD, Compare to cluster

CHMU_YEAST / P32178 Chorismate mutase; CM; EC 5.4.99.5 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
256 amino acids: PaperBLAST, CDD, Compare to cluster

CHMU_PICAN / Q9P4D8 Chorismate mutase; CM; EC 5.4.99.5 from Pichia angusta (Yeast) (Hansenula polymorpha)
280 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 181-202 amino acids (not heteromeric)

CHMU_PSEAE / Q9HU05 Monofunctional chorismate mutase; EC 5.4.99.5 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PFams: CM_2
185 amino acids: PaperBLAST, CDD, Compare to cluster

B2JYH9 chorismate mutase (EC 5.4.99.5) from Paraburkholderia phymatum
PFams: CM_2
182 amino acids: PaperBLAST, CDD, Compare to cluster

Q2SY64 chorismate mutase (EC 5.4.99.5) from Burkholderia thailandensis
PFams: CM_2
202 amino acids: PaperBLAST, CDD, Compare to cluster

SCMU_MYCS2 / A0QU81 Secreted chorismate mutase; CM; EC 5.4.99.5 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
PFams: CM_2
181 amino acids: PaperBLAST, CDD, Compare to cluster

SCMU_MYCTU / P9WIB9 Secreted chorismate mutase; CM; *MtCM; EC 5.4.99.5 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: CM_2
199 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 365-386 amino acids (not heteromeric)

C7EXK8 prephenate dehydratase (EC 4.2.1.51); chorismate mutase (EC 5.4.99.5) from Escherichia coli
PFams: CM_2, PDT
386 amino acids: PaperBLAST, CDD, Compare to cluster

b2599 fused chorismate mutase/prephenate dehydratase (EC 5.4.99.5; EC 4.2.1.51) from Escherichia coli K-12 substr. MG1655
P0A9J8 fused chorismate mutase/prephenate dehydratase (EC 5.4.99.5; EC 4.2.1.51) from Escherichia coli (strain K12)
CMPDT_ECOLI / P0A9J8 Bifunctional chorismate mutase/prephenate dehydratase; Chorismate mutase-prephenate dehydratase; P-protein; EC 5.4.99.5; EC 4.2.1.51 from Escherichia coli (strain K12)
CH_024084 P-protein; EC 4.2.1.51; EC 5.4.99.5 from Escherichia coli K12
PFams: CM_2, PDT
386 amino acids: PaperBLAST, CDD, Compare to cluster

CMPDT_STUST / P27603 Bifunctional chorismate mutase/prephenate dehydratase; Chorismate mutase-prephenate dehydratase; P-protein; EC 5.4.99.5; EC 4.2.1.51 from Stutzerimonas stutzeri (Pseudomonas stutzeri)
PFams: CM_2, PDT, ACT
365 amino acids: PaperBLAST, CDD, Compare to cluster

CMPDT_BUCAI / P57472 Bifunctional chorismate mutase/prephenate dehydratase; Chorismate mutase-prephenate dehydratase; P-protein; EC 5.4.99.5; EC 4.2.1.51 from Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
P57472 prephenate dehydratase (EC 4.2.1.51) from Buchnera aphidicola
PFams: CM_2, PDT
385 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 4 181-186 amino acids (not heteromeric)

CHMU_ENTAG / P42517 Monofunctional chorismate mutase; CM-F; EC 5.4.99.5 from Enterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans)
PFams: CM_2
181 amino acids: PaperBLAST, CDD, Compare to cluster

SCMU_YERPE / Q7CHH5 Secreted chorismate mutase; CM; *YpCM; EC 5.4.99.5 from Yersinia pestis
Q7CHH5 chorismate mutase (EC 5.4.99.5) from Yersinia pestis
PFams: CM_2
186 amino acids: PaperBLAST, CDD, Compare to cluster

CHMU_SALTM / Q93LJ4 Monofunctional chorismate mutase; EC 5.4.99.5 from Salmonella typhimurium
PFams: CM_2
181 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 5 275-286 amino acids (not heteromeric)

B6C761 chorismate mutase (EC 5.4.99.5) from Globodera rostochiensis
PFams: CM_2
286 amino acids: PaperBLAST, CDD, Compare to cluster

Q3LUE0 chorismate mutase (EC 5.4.99.5) from Heterodera schachtii
PFams: CM_2
275 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 6 122-127 amino acids (not heteromeric)

AROH_BACSU / P19080 Chorismate mutase AroH; CM; EC 5.4.99.5 from Bacillus subtilis (strain 168)
PFams: CM_1
127 amino acids: PaperBLAST, CDD, Compare to cluster

AROH_THETH / Q84FH6 Chorismate mutase AroH; EC 5.4.99.5 from Thermus thermophilus
Q84FH6 chorismate mutase (EC 5.4.99.5) from Thermus thermophilus
PFams: CM_1
122 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 7 373-377 amino acids (not heteromeric)

P43902 prephenate dehydrogenase (EC 1.3.1.12) from Haemophilus influenzae
PFams: CM_2, PDH_N, PDH_C
377 amino acids: PaperBLAST, CDD, Compare to cluster

b2600 fused chorismate mutase/prephenate dehydrogenase (EC 5.4.99.5; EC 1.3.1.12) from Escherichia coli K-12 substr. MG1655
P07023 fused chorismate mutase/prephenate dehydrogenase (EC 5.4.99.5; EC 1.3.1.12) from Escherichia coli (strain K12)
PFams: CM_2, PDH_N, PDH_C
373 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 8 367-379 amino acids (not heteromeric)

Echvi_0120 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase / chorismate mutase (EC 2.5.1.54; EC 5.4.99.5) from Echinicola vietnamensis KMM 6221, DSM 17526
PFams: DAHP_synth_1, CM_2
367 amino acids: PaperBLAST, CDD, Compare to cluster

CA265_RS11635 chorismate mutase (EC 5.4.99.5) from Pedobacter sp. GW460-11-11-14-LB5
PFams: DAHP_synth_1, CM_2
379 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 9 591-620 amino acids (not heteromeric)

O30012 prephenate dehydrogenase (EC 1.3.1.12); prephenate dehydratase (EC 4.2.1.51); chorismate mutase (EC 5.4.99.5) from Archaeoglobus fulgidus
PFams: PDH_N, PDH_C, CM_2, PDT, ACT
620 amino acids: PaperBLAST, CDD, Compare to cluster

Q74NC4 prephenate dehydratase (EC 4.2.1.51) from Nanoarchaeum equitans
PFams: CM_2, PDT, ACT
591 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 10 104-105 amino acids (not heteromeric)

CHMU_MYCTU / P9WIC1 Intracellular chorismate mutase; CM; EC 5.4.99.5 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WIC1 chorismate mutase (EC 5.4.99.5) from Mycobacterium tuberculosis
PFams: CM_2
105 amino acids: PaperBLAST, CDD, Compare to cluster

CHMU_MYCS2 / A0R3N5 Intracellular chorismate mutase; CM; EC 5.4.99.5 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
PFams: CM_2
104 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/8 heteromeric)

A8AAX2 prephenate dehydrogenase (NADP+) (EC 1.3.1.13) from Ignicoccus hospitalis
PFams: CM_2, Rossmann-like, F420_oxidored, NAD_binding_2, PDH_N, PDH_C
348 amino acids: PaperBLAST, CDD

P39912 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54); chorismate mutase (EC 5.4.99.5) from Bacillus subtilis
PFams: CM_2, DAHP_synth_1, NeuB
358 amino acids: PaperBLAST, CDD

PAPB_STRPR / P72541 4-amino-4-deoxychorismate mutase; ADC mutase; EC 5.4.99.67 (from HMM only) from Streptomyces pristinaespiralis
P72541 4-amino-4-deoxychorismate mutase (EC 5.4.99.67) from Streptomyces pristinaespiralis
PFams: CM_2
129 amino acids: PaperBLAST, CDD

MBTI_MYCTU / P9WFX1 Salicylate synthase; Chorismate mutase; CM; Isochorismate synthase/isochorismate lyase; Mycobactin synthase protein; EC 5.4.99.5; EC 4.2.99.21; EC 5.4.4.2 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WFX1 isochorismate lyase (EC 4.2.99.21); isochorismate synthase (EC 5.4.4.2) from Mycobacterium tuberculosis
PFams: Chorismate_bind
450 amino acids: PaperBLAST, CDD

Q51507 isochorismate pyruvate lyase (EC 4.2.99.21) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PCHB_PSEAE / Q51507 Isochorismate pyruvate lyase; IPL; Chorismate mutase; CM; Salicylate biosynthesis protein; EC 4.2.99.21; EC 5.4.99.5 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Q51507 isochorismate lyase (EC 4.2.99.21) from Pseudomonas aeruginosa
PFams: CM_2
101 amino acids: PaperBLAST, CDD

CMU1_USTMA / A0A0D1DWQ2 Secreted chorismate mutase; EC 5.4.99.5 from Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
290 amino acids: PaperBLAST, CDD

CHMU_METJA / Q57696 Chorismate mutase; CM; Monofunctional chorismate mutase AroQ(f); EC 5.4.99.5 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
PFams: CM_2
99 amino acids: PaperBLAST, CDD

F2RB77 4-amino-4-deoxychorismate mutase (EC 5.4.99.67) (from HMM only) from Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
PFams: CM_2
103 amino acids: PaperBLAST, CDD