Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for HPD (4-hydroxyphenylpyruvate dioxygenase) in L-tyrosine catabolism

Or see other characterized proteins similar to HPD

Or see all steps for L-tyrosine catabolism

Or cluster curated proteins matching a keyword

Definition of HPD

Curated proteins or TIGRFams with EC 1.13.11.27
Ignore hits to Q8EKK9 when looking for 'other' hits (4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27))
Ignore hits to Q9RSJ4 when looking for 'other' hits (4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27))
Comment: Q8EKK9 and Q9RSJ4 are misannotated in BRENDA

Fetched 18 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 18 of these sequences

Found 1 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 346-445 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

HPPD_STRAW / Q53586 4-hydroxyphenylpyruvate dioxygenase; 4HPPD; HPD; HPPDase; EC 1.13.11.27 from Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Q53586 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Streptomyces avermitilis
PFams: Glyoxalase, Glyoxalase
381 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1S5V3J7 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Medicago sativa
PFams: Glyoxalase
435 amino acids: PaperBLAST, CDD, Compare to cluster

HMAS_AMYOR / O52791 4-hydroxymandelate synthase; HMS; HmaS; 4-hydroxyphenylpyruvate dioxygenase II; EC 1.13.11.46 (from HMM only) from Amycolatopsis orientalis (Nocardia orientalis)
O52791 4-hydroxymandelate oxidase (EC 1.1.3.46) from Amycolatopsis orientalis
PFams: Glyoxalase_5, Glyoxalase, Glyoxalase_4
357 amino acids: PaperBLAST, CDD, Compare to cluster

P32754 4-hydroxyphenylpyruvate dioxygenase subunit (EC 1.13.11.27) from Homo sapiens
HPPD_HUMAN / P32754 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; EC 1.13.11.27 from Homo sapiens (Human)
P32754 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Homo sapiens
PFams: Glyoxalase, Glyoxalase
393 amino acids: PaperBLAST, CDD, Compare to cluster

HPPD_RAT / P32755 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; F Alloantigen; F protein; EC 1.13.11.27 from Rattus norvegicus (Rat)
P32755 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Rattus norvegicus
PFams: Glyoxalase, Glyoxalase_4, Glyoxalase
393 amino acids: PaperBLAST, CDD, Compare to cluster

P80064 4-hydroxyphenylpyruvate dioxygenase subunit (EC 1.13.11.27) from Pseudomonas sp. (strain P.J. 874)
P80064 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Pseudomonas fluorescens
PFams: Glyoxalase_5, Glyoxalase
357 amino acids: PaperBLAST, CDD, Compare to cluster

Q09PG8 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from uncultured soil bacterium
PFams: Glyoxalase_5, Glyoxalase, Glyoxalase_4
367 amino acids: PaperBLAST, CDD, Compare to cluster

Q6KZ98 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Picrophilus torridus
PFams: Glyoxalase, Glyoxalase
368 amino acids: PaperBLAST, CDD, Compare to cluster

LLY_LEGPC / P69053 4-hydroxyphenylpyruvate dioxygenase; 4HPPD; HPD; HPPDase; Legiolysin; EC 1.13.11.27 from Legionella pneumophila (strain Corby)
PFams: Glyoxalase_5, Glyoxalase, Glyoxalase_4
348 amino acids: PaperBLAST, CDD, Compare to cluster

HPPD_ARATH / P93836 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; EC 1.13.11.27 from Arabidopsis thaliana (Mouse-ear cress)
P93836 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Arabidopsis thaliana
PFams: Glyoxalase
445 amino acids: PaperBLAST, CDD, Compare to cluster

SO1962 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Shewanella oneidensis MR-1
PFams: Glyoxalase_5, Glyoxalase
346 amino acids: PaperBLAST, CDD, Compare to cluster

Ac3H11_1849 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Acidovorax sp. GW101-3H11
PFams: Glyoxalase_5, Glyoxalase
381 amino acids: PaperBLAST, CDD, Compare to cluster

Psest_3514 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Pseudomonas stutzeri RCH2
PFams: Glyoxalase_5, Glyoxalase, Glyoxalase_4
361 amino acids: PaperBLAST, CDD, Compare to cluster

PfGW456L13_2935 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Pseudomonas fluorescens GW456-L13
PFams: Glyoxalase_5, Glyoxalase
358 amino acids: PaperBLAST, CDD, Compare to cluster

AO353_26925 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Pseudomonas fluorescens FW300-N2E3
PFams: Glyoxalase_5, Glyoxalase
358 amino acids: PaperBLAST, CDD, Compare to cluster

AO356_22845 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Pseudomonas fluorescens FW300-N2C3
PFams: Glyoxalase_5, Glyoxalase, Glyoxalase_4
358 amino acids: PaperBLAST, CDD, Compare to cluster

Pf6N2E2_456 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Pseudomonas fluorescens FW300-N2E2
PFams: Glyoxalase_5, Glyoxalase, Glyoxalase_4
358 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

Q55810 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Synechocystis sp. (strain PCC 6803 / Kazusa)
PFams: Glyoxalase, Glyoxalase_4
339 amino acids: PaperBLAST, CDD
(similar to BRENDA::O52791 from Cluster 1, but similarity to seed sequence is below thresholds)