Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for ilvC (2-hydroxy-3-ketol-acid reductoisomerase) in L-valine biosynthesis

Or see other characterized proteins similar to ilvC

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Definition of ilvC

Curated proteins or TIGRFams with EC 1.1.1.86
Curated proteins or TIGRFams with EC 1.1.1.382
Curated proteins or TIGRFams with EC 1.1.1.383
Curated sequence CH_123630: mitochondrial ketol-acid reductoisomerase
Comment: The three EC numbers correspond to different preferences for NAD(P)H as the cofactor; the transformations to the carbon skeleton are the same. CH_123630 is added because it is annotated as this but with no EC number.

Fetched 34 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 34 of these sequences

Found 3 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 328-400 amino acids (not heteromeric)

A0A0K2AZ61 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Streptomyces ambofaciens
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2, IlvC
332 amino acids: PaperBLAST, CDD, Compare to cluster

ILVC_MYCTU / P9WKJ7 Ketol-acid reductoisomerase (NADP(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.86 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
A5U713 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Mycobacterium tuberculosis
P9WKJ7 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Mycobacterium tuberculosis
PFams: 2-Hacid_dh_C, IlvN, NAD_binding_2, IlvC
337 amino acids: PaperBLAST, CDD, Compare to cluster

A6UW80 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Methanococcus aeolicus
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2, IlvC
329 amino acids: PaperBLAST, CDD, Compare to cluster

ILVC_ALIAD / C8WR67 Ketol-acid reductoisomerase (NADP(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.86 from Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC 27009 / DSM 446 / BCRC 14685 / JCM 5260 / KCTC 1825 / NBRC 15652 / NCIMB 11725 / NRRL B-14509 / 104-IA) (Bacillus acidocaldarius)
C8WR67 ketol-acid reductoisomerase (NAD+) (EC 1.1.1.382); ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Alicyclobacillus acidocaldarius subsp. acidocaldarius
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2, IlvC
344 amino acids: PaperBLAST, CDD, Compare to cluster

ILVC_SLAES / D0WGK0 Ketol-acid reductoisomerase (NADP(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.86 from Slackia exigua (strain ATCC 700122 / DSM 15923 / CIP 105133 / JCM 11022 / KCTC 5966 / S-7)
D0WGK0 ketol-acid reductoisomerase [NAD(P)+] (EC 1.1.1.383) from Slackia exigua
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2, IlvC
342 amino acids: PaperBLAST, CDD, Compare to cluster

D3PT81 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Meiothermus ruber
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, IlvC
339 amino acids: PaperBLAST, CDD, Compare to cluster

D6EC76 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Streptomyces lividans
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2, IlvC
332 amino acids: PaperBLAST, CDD, Compare to cluster

D6ERQ9 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Streptomyces lividans
Q9Z565 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Streptomyces coelicolor
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2, IlvC
332 amino acids: PaperBLAST, CDD, Compare to cluster

ILVC_LACLA / Q02138 Ketol-acid reductoisomerase (NADP(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.86 from Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Q02138 ketol-acid reductoisomerase [NAD(P)+] (EC 1.1.1.383) from Lactococcus lactis subsp. lactis
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2, IlvC
340 amino acids: PaperBLAST, CDD, Compare to cluster

Q2FWK4 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Staphylococcus aureus
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2, IlvC
334 amino acids: PaperBLAST, CDD, Compare to cluster

Q4J8K9 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Sulfolobus acidocaldarius
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2, IlvC
332 amino acids: PaperBLAST, CDD, Compare to cluster

Q57179 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Corynebacterium glutamicum
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2, IlvC
338 amino acids: PaperBLAST, CDD, Compare to cluster

Q59818 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Streptomyces avermitilis
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2, IlvC
333 amino acids: PaperBLAST, CDD, Compare to cluster

Q9FBT8 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Streptomyces coelicolor
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2, IlvC
332 amino acids: PaperBLAST, CDD, Compare to cluster

CH_123630 mitochondrial ketol-acid reductoisomerase from Candida albicans
PFams: IlvN, IlvC
400 amino acids: PaperBLAST, CDD, Compare to cluster

ILVC_METS5 / A4YI15 Ketol-acid reductoisomerase (NAD(P)(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.383 from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2, IlvC
335 amino acids: PaperBLAST, CDD, Compare to cluster

ILVC_DESOH / A8ZTR0 Ketol-acid reductoisomerase (NAD(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; EC 1.1.1.382 from Desulfosudis oleivorans (strain DSM 6200 / JCM 39069 / Hxd3) (Desulfococcus oleovorans)
PFams: IlvN, IlvC
352 amino acids: PaperBLAST, CDD, Compare to cluster

ILVC_HYDS0 / B4U6I9 Ketol-acid reductoisomerase (NAD(P)(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.383 from Hydrogenobaculum sp. (strain Y04AAS1)
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2, IlvC
333 amino acids: PaperBLAST, CDD, Compare to cluster

ILVC_AZOVD / C1DFH7 Ketol-acid reductoisomerase (NADP(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.86 from Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
C1DFH7 ketol-acid reductoisomerase [NAD(P)+] (EC 1.1.1.383); ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Azotobacter vinelandii
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2, IlvC
338 amino acids: PaperBLAST, CDD, Compare to cluster

ILVC_IGNAA / E0SRA9 Ketol-acid reductoisomerase (NAD(P)(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.383 from Ignisphaera aggregans (strain DSM 17230 / JCM 13409 / AQ1.S1)
E0SRA9 ketol-acid reductoisomerase (NAD+) (EC 1.1.1.382); ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Ignisphaera aggregans
PFams: IlvN, F420_oxidored, NAD_binding_2, IlvC
335 amino acids: PaperBLAST, CDD, Compare to cluster

ILVC_THEPS / K4LVZ1 Ketol-acid reductoisomerase (NAD(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.382 from Thermacetogenium phaeum (strain ATCC BAA-254 / DSM 26808 / PB)
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2, IlvC
332 amino acids: PaperBLAST, CDD, Compare to cluster

ILVC_ARCFU / O28294 Ketol-acid reductoisomerase (NAD(P)(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.383 from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
O28294 ketol-acid reductoisomerase (NAD+) (EC 1.1.1.382) from Archaeoglobus fulgidus
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, IlvC
332 amino acids: PaperBLAST, CDD, Compare to cluster

ILV5_YEAST / P06168 Ketol-acid reductoisomerase, mitochondrial; Acetohydroxy-acid reductoisomerase; Alpha-keto-beta-hydroxylacyl reductoisomerase; Isoleucine-plus-valine requiring protein 5; EC 1.1.1.86 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: IlvN, IlvC
395 amino acids: PaperBLAST, CDD, Compare to cluster

ILVC_SYNWW / Q0AV19 Ketol-acid reductoisomerase (NAD(P)(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.383 from Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2, IlvC
337 amino acids: PaperBLAST, CDD, Compare to cluster

ILVC_UNCAG / Q64BR7 Ketol-acid reductoisomerase (NAD(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.382 from Uncultured archaeon GZfos26G2
Q64BR7 ketol-acid reductoisomerase (NAD+) (EC 1.1.1.382); ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from uncultured archaeon GZfos26G2
PFams: IlvN, IlvC
332 amino acids: PaperBLAST, CDD, Compare to cluster

ILVC_PSEAE / Q9HVA2 Ketol-acid reductoisomerase (NADP(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.86 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2, IlvC
338 amino acids: PaperBLAST, CDD, Compare to cluster

O27491 acetohydroxy-acid isomeroreductase subunit (EC 1.1.1.383) from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2, IlvC
328 amino acids: PaperBLAST, CDD, Compare to cluster

Q0KCU2 acetohydroxyacid isomeroreductase (EC 1.1.1.86) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2, IlvC
338 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 491-492 amino acids (not heteromeric)

A0KS29 ketol-acid reductoisomerase [NAD(P)+] (EC 1.1.1.383) from Shewanella sp.
PFams: IlvN, IlvC, IlvC
492 amino acids: PaperBLAST, CDD, Compare to cluster

A6TGG1 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Klebsiella pneumoniae subsp. pneumoniae
PFams: IlvN, IlvC, IlvC
491 amino acids: PaperBLAST, CDD, Compare to cluster

b3774 ketol-acid reductoisomerase (NADP⁺) (EC 1.1.1.86; EC 1.1.1.169) from Escherichia coli K-12 substr. MG1655
P05793 ketol-acid reductoisomerase (NADP⁺) (EC 1.1.1.86; EC 1.1.1.169) from Escherichia coli (strain K12)
ILVC_ECOLI / P05793 Ketol-acid reductoisomerase (NADP(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 2; Ketol-acid reductoisomerase type II; EC 1.1.1.86 from Escherichia coli (strain K12)
P05793 ketol-acid reductoisomerase [NAD(P)+] (EC 1.1.1.383); ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Escherichia coli
CH_003903 ketol-acid reductoisomerase; EC 1.1.1.86 from Escherichia coli K12
PFams: IlvN, IlvC, IlvC
491 amino acids: PaperBLAST, CDD, Compare to cluster

ILVC_SALTY / P05989 Ketol-acid reductoisomerase (NADP(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 2; Ketol-acid reductoisomerase type II; EC 1.1.1.86 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PFams: IlvN, IlvC, IlvC
491 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 578-595 amino acids (not heteromeric)

ILV5_ORYSJ / Q65XK0 Ketol-acid reductoisomerase, chloroplastic; Acetohydroxy-acid reductoisomerase; Alpha-keto-beta-hydroxylacyl reductoisomerase; Protein KARI; EC 1.1.1.86 from Oryza sativa subsp. japonica (Rice)
Q65XK0 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Oryza sativa Japonica Group
PFams: IlvN, IlvC, IlvC
578 amino acids: PaperBLAST, CDD, Compare to cluster

ILV5_SPIOL / Q01292 Ketol-acid reductoisomerase, chloroplastic; Acetohydroxy-acid reductoisomerase; Alpha-keto-beta-hydroxylacyl reductoisomerase; EC 1.1.1.86 from Spinacia oleracea (Spinach)
PFams: IlvN, IlvC, IlvC
595 amino acids: PaperBLAST, CDD, Compare to cluster