Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for acdH (isobutyryl-CoA dehydrogenase) in L-valine catabolism

Or see other characterized proteins similar to acdH

Or see all steps for L-valine catabolism

Or cluster curated proteins matching a keyword

Definition of acdH

Curated proteins or TIGRFams with EC 1.3.8.5
Ignore hits to 200844 when looking for 'other' hits (2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5))
Ignore hits to GFF2715 when looking for 'other' hits (2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5))
Ignore hits to Ac3H11_2996 when looking for 'other' hits (2-methyl-branched-chain-enoyl-CoA reductase (EC 1.3.8.5))
Ignore hits to GFF2397 when looking for 'other' hits (2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5))
Ignore hits to Pf1N1B4_4787 when looking for 'other' hits (2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5))
Ignore hits to AO356_26355 when looking for 'other' hits (2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5))
Ignore hits to Pf6N2E2_1146 when looking for 'other' hits (2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5))
Ignore hits to PfGW456L13_2983 when looking for 'other' hits (Short-chain acyl-CoA dehydrogenase (EC 1.3.8.1))
Curated sequence GFF2392: isobutyryl-CoA dehydrogenase (EC 1.3.8.1)
Ignore hits to MONOMER-17424 when looking for 'other' hits (short-chain acyl-CoA dehydrogenase monomer (EC 1.3.8.1))
Comment: EC 1.3.8.5 includes isobutyryl-CoA dehydrogenases and sometimes (2S)-2-methylbutanoyl-CoA dehydrogenases (involved in isoleucine degradation, usually given EC 1.3.8.5 as well) or 3-methylbutanoyl-CoA dehydrogenases (involved in leucine degradation, usually given EC 1.3.8.4). Some enzymes act on all three methylacyl-CoA substrates. Other genes are required only for isoleucine degradation and their activity on isobutyryl-CoA is uncertain, so they are marked ignore. Also add Psest_2440 (GFF2392), given a different EC number, and ignore PfGW456L13_2983 (given a different EC but involved in isoleucine degradation) and PP_2216 (MONOMER-17424), also involved in isoleucine degradation.

Fetched 8 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 8 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 375-432 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

ACDSB_HUMAN / P45954 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; SBCAD; 2-methyl branched chain acyl-CoA dehydrogenase; 2-MEBCAD; 2-methylbutyryl-coenzyme A dehydrogenase; 2-methylbutyryl-CoA dehydrogenase; EC 1.3.8.5 from Homo sapiens (Human)
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
432 amino acids: PaperBLAST, CDD, Compare to cluster

P70584 2-methyl branched chain acyl-CoA dehydrogenase subunit (EC 1.3.8.5) from Rattus norvegicus
ACDSB_RAT / P70584 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; SBCAD; 2-methyl branched chain acyl-CoA dehydrogenase; 2-MEBCAD; 2-methylbutyryl-coenzyme A dehydrogenase; 2-methylbutyryl-CoA dehydrogenase; EC 1.3.8.5 from Rattus norvegicus (Rat)
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
432 amino acids: PaperBLAST, CDD, Compare to cluster

Q9XCG5 acyl-CoA dehydrogenase subunit (EC 1.3.8.4; EC 1.3.8.5) from Streptomyces avermitilis
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
386 amino acids: PaperBLAST, CDD, Compare to cluster

PS417_13840 isobutyryl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas simiae WCS417
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
383 amino acids: PaperBLAST, CDD, Compare to cluster

Psest_2440 isobutyryl-CoA dehydrogenase (EC 1.3.8.1) from Pseudomonas stutzeri RCH2
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
383 amino acids: PaperBLAST, CDD, Compare to cluster

PfGW456L13_2985 isobutyryl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas fluorescens GW456-L13
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
383 amino acids: PaperBLAST, CDD, Compare to cluster

AO353_25670 isobutyryl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas fluorescens FW300-N2E3
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
383 amino acids: PaperBLAST, CDD, Compare to cluster

AO353_25680 2-methylbutanoyl-CoA dehydrogenase / butanoyl-CoA dehydrogenase / isobutyryl-CoA dehydrogenase (EC 1.3.8.1; EC 1.3.8.5) from Pseudomonas fluorescens FW300-N2E3
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
375 amino acids: PaperBLAST, CDD, Compare to cluster