GapMind for catabolism of small carbon sources

 

Clusters of Characterized Proteins

Clustering the characterized proteins for acn ((2R,3S)-2-methylcitrate dehydratase) in L-valine catabolism

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Definition of acn

Fetched 10 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 10 of these sequences

Found 2 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 869-980 amino acids (not heteromeric)

ACON_LEGPH / P37032 Aconitate hydratase A; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; IP210; Iron-responsive protein-like; IRP-like; Major iron-containing protein; MICP; Probable 2-methyl-cis-aconitate hydratase; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
PFams: Aconitase, Aconitase_C
891 amino acids: PaperBLAST, CDD, Compare to cluster

O53166 aconitase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
ACNA_MYCTU / O53166 Aconitate hydratase A; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; Iron-responsive protein-like; IRP-like; Probable 2-methyl-cis-aconitate hydratase; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: Aconitase, Aconitase_C
943 amino acids: PaperBLAST, CDD, Compare to cluster

ACNA_BRADU / P70920 Aconitate hydratase A; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; Iron-responsive protein-like; IRP-like; Probable 2-methyl-cis-aconitate hydratase; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
PFams: Aconitase, Aconitase_C
906 amino acids: PaperBLAST, CDD, Compare to cluster

ACNA_THET8 / Q5SMF6 Aconitate hydratase A; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; Iron-responsive protein-like; IRP-like; Probable 2-methyl-cis-aconitate hydratase; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
PFams: Aconitase, Aconitase_C
902 amino acids: PaperBLAST, CDD, Compare to cluster

ACNA_CORGL / Q8NQ98 Aconitate hydratase A; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; Iron-responsive protein-like; IRP-like; Probable 2-methyl-cis-aconitate hydratase; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
PFams: Aconitase, Aconitase_C
939 amino acids: PaperBLAST, CDD, Compare to cluster

Q8ZP52 aconitate hydratase 1 (EC 4.2.1.99) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
ACNA_SALTY / Q8ZP52 Aconitate hydratase A; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; 2-methyl-cis-aconitate hydratase; Iron-responsive protein-like; IRP-like; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PFams: Aconitase, Aconitase_C
891 amino acids: PaperBLAST, CDD, Compare to cluster

ACNA_CUPNE / Q937N8 Aconitate hydratase A; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; Iron-responsive protein-like; IRP-like; Probable 2-methyl-cis-aconitate hydratase; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Cupriavidus necator (Alcaligenes eutrophus) (Ralstonia eutropha)
PFams: Aconitase, Aconitase_C
869 amino acids: PaperBLAST, CDD, Compare to cluster

Ac3H11_1140 2-methylisocitrate dehydratase (EC 4.2.1.99) from Acidovorax sp. GW101-3H11
PFams: Aconitase, Aconitase_C
980 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 865-865 amino acids (not heteromeric)

b0118 AcnB (EC 4.2.1.99) from Escherichia coli K-12 substr. MG1655
P36683 AcnB (EC 4.2.1.99) from Escherichia coli (strain K12)
ACNB_ECOLI / P36683 Aconitate hydratase B; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; 2-methyl-cis-aconitate hydratase; Iron-responsive protein-like; IRP-like; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Escherichia coli (strain K12)
P36683 aconitate hydratase (EC 4.2.1.3) from Escherichia coli
GB|AAZ86920.1 aconitate hydratas; EC 4.2.1.3 from Escherichia coli
PFams: Aconitase_B_N, Aconitase_2_N, Aconitase
865 amino acids: PaperBLAST, CDD, Compare to cluster

Q8ZRS8 aconitate hydratase 2 (EC 4.2.1.99) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
ACNB_SALTY / Q8ZRS8 Aconitate hydratase B; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; 2-methyl-cis-aconitate hydratase; Iron-responsive protein-like; IRP-like; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PFams: Aconitase_B_N, Aconitase_2_N, Aconitase
865 amino acids: PaperBLAST, CDD, Compare to cluster