GapMind for catabolism of small carbon sources

 

Clusters of Characterized Proteins

Clustering the characterized proteins for bkdA (branched-chain alpha-ketoacid dehydrogenase, E1 component alpha subunit) in L-valine catabolism

Or see other characterized proteins similar to bkdA

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Or cluster curated proteins matching a keyword

Definition of bkdA

Fetched 15 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 15 of these sequences

Found 1 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 367-472 amino acids (6/14 heteromeric)

The first sequence in each cluster is the seed.

P12694 branched-chain α-keto acid dehydrogenase E1 component α subunit (EC 1.2.4.4) from Homo sapiens
ODBA_HUMAN / P12694 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Homo sapiens (Human)
PFams: E1_dh
Heteromeric, 445 amino acids: PaperBLAST, CDD, Compare to cluster

Q72GU1 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) (EC 1.2.4.4) from Thermus thermophilus
PFams: E1_dh
367 amino acids: PaperBLAST, CDD, Compare to cluster

GI|790514 2-oxoisovalerate dehydrogenase subunit alpha; EC 1.2.4.4 from Pseudomonas putida
PFams: OxoDH_E1alpha_N, E1_dh
410 amino acids: PaperBLAST, CDD, Compare to cluster

ODBA_CAEEL / O45924 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; EC 1.2.4.4 from Caenorhabditis elegans
PFams: E1_dh, Transketolase_N
431 amino acids: PaperBLAST, CDD, Compare to cluster

ODBA_BOVIN / P11178 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Bos taurus (Bovine)
PFams: E1_dh
Heteromeric, 455 amino acids: PaperBLAST, CDD, Compare to cluster

BKDA_MYCTU / P9WIS3 3-methyl-2-oxobutanoate dehydrogenase subunit alpha; Branched-chain alpha-ketoacid dehydrogenase E1 component subunit alpha; BCKADH E1-alpha; EC 1.2.4.4 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: E1_dh, DXP_synthase_N
Heteromeric, 367 amino acids: PaperBLAST, CDD, Compare to cluster

ODBA_THET8 / Q5SLR4 2-oxoisovalerate dehydrogenase subunit alpha; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDH E1-alpha; EC 1.2.4.4 from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
PFams: E1_dh
Heteromeric, 367 amino acids: PaperBLAST, CDD, Compare to cluster

ODBA2_ARATH / Q84JL2 2-oxoisovalerate dehydrogenase subunit alpha 2, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Arabidopsis thaliana (Mouse-ear cress)
PFams: E1_dh
Heteromeric, 472 amino acids: PaperBLAST, CDD, Compare to cluster

ODBA1_ARATH / Q9LPL5 2-oxoisovalerate dehydrogenase subunit alpha 1, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Arabidopsis thaliana (Mouse-ear cress)
PFams: E1_dh
Heteromeric, 472 amino acids: PaperBLAST, CDD, Compare to cluster

SMc03201 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) (EC 1.2.4.4) from Sinorhizobium meliloti 1021
PFams: OxoDH_E1alpha_N, E1_dh
410 amino acids: PaperBLAST, CDD, Compare to cluster

PfGW456L13_3540 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) (EC 1.2.4.4) from Pseudomonas fluorescens GW456-L13
PFams: OxoDH_E1alpha_N, E1_dh
411 amino acids: PaperBLAST, CDD, Compare to cluster

AO353_26635 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) (EC 1.2.4.4) from Pseudomonas fluorescens FW300-N2E3
PFams: OxoDH_E1alpha_N, E1_dh
411 amino acids: PaperBLAST, CDD, Compare to cluster

AO356_22990 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) (EC 1.2.4.4) from Pseudomonas fluorescens FW300-N2C3
PFams: OxoDH_E1alpha_N, E1_dh
411 amino acids: PaperBLAST, CDD, Compare to cluster

Pf6N2E2_481 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) (EC 1.2.4.4) from Pseudomonas fluorescens FW300-N2E2
PFams: OxoDH_E1alpha_N, E1_dh
411 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (1/1 heteromeric)

P37940 2-keto-isovalerate dehydrogenase component α subunit (EC 1.2.4.4) from Bacillus subtilis (strain 168)
PFams: E1_dh
Heteromeric, 330 amino acids: PaperBLAST, CDD
(similar to BRENDA::Q72GU1 from Cluster 1, but similarity to seed sequence is below thresholds)