GapMind for catabolism of small carbon sources

 

Clusters of Characterized Proteins

Clustering the characterized proteins for prpD (2-methylcitrate dehydratase) in L-valine catabolism

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Definition of prpD

Fetched 11 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 10 of these sequences

Found 2 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 472-520 amino acids (not heteromeric)

P74840 2-methylcitrate dehydratase (EC 4.2.1.79) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PRPD_SALTY / P74840 2-methylcitrate dehydratase; 2-MC dehydratase; Aconitate hydratase; ACN; Aconitase; EC 4.2.1.79; EC 4.2.1.3 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
P74840 2-methylcitrate dehydratase (EC 4.2.1.79) from Salmonella enterica
PFams: MmgE_PrpD
483 amino acids: PaperBLAST, CDD, Compare to cluster

b0334 2-methylcitrate dehydratase (EC 4.2.1.79) from Escherichia coli K-12 substr. MG1655
P77243 2-methylcitrate dehydratase (EC 4.2.1.79) from Escherichia coli (strain K12)
PRPD_ECOLI / P77243 2-methylcitrate dehydratase; 2-MC dehydratase; (2S,3S)-2-methylcitrate dehydratase; Aconitate hydratase; ACN; Aconitase; EC 4.2.1.79; EC 4.2.1.3 from Escherichia coli (strain K12)
P77243 2-methylcitrate dehydratase (EC 4.2.1.79) from Escherichia coli
PDB|1SZQ 2-methylcitrate dehydratase; EC 4.2.1.79 from Escherichia coli K12
PFams: MmgE_PrpD
483 amino acids: PaperBLAST, CDD, Compare to cluster

MMGE_BACSU / P45859 Citrate/2-methylcitrate dehydratase; EC 4.2.1.- from Bacillus subtilis (strain 168)
P45859 2-methylcitrate dehydratase (EC 4.2.1.79) from Bacillus subtilis
PFams: MmgE_PrpD
472 amino acids: PaperBLAST, CDD, Compare to cluster

PRPD_YEAST / Q12428 Probable 2-methylcitrate dehydratase; 2-MC dehydratase; (2S,3S)-2-methylcitrate dehydratase; EC 4.2.1.79 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: MmgE_PrpD
516 amino acids: PaperBLAST, CDD, Compare to cluster

PRPD_YARLI / Q6C354 2-methylcitrate dehydratase, mitochondrial; EC 4.2.1.79 from Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
PFams: MmgE_PrpD
520 amino acids: PaperBLAST, CDD, Compare to cluster

PRPD_CUPNE / Q937N6 2-methylcitrate dehydratase; 2-MC dehydratase; Aconitate hydratase; ACN; Aconitase; EC 4.2.1.79; EC 4.2.1.3 from Cupriavidus necator (Alcaligenes eutrophus) (Ralstonia eutropha)
PFams: MmgE_PrpD
484 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 498-526 amino acids (not heteromeric)

PRPD_MYCTE / H8F0D6 2-methylcitrate dehydratase; 2-MC dehydratase; Aconitate hydratase; ACN; Aconitase; EC 4.2.1.79; EC 4.2.1.3 from Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
PFams: MmgE_PrpD
505 amino acids: PaperBLAST, CDD, Compare to cluster

PRPD_MYCTU / O06582 2-methylcitrate dehydratase; 2-MC dehydratase; Aconitate hydratase; ACN; Aconitase; EC 4.2.1.79; EC 4.2.1.3 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: MmgE_PrpD
526 amino acids: PaperBLAST, CDD, Compare to cluster

PRPD1_CORGL / Q8NSH9 2-methylcitrate dehydratase 1; 2-MC dehydratase; EC 4.2.1.79 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
PFams: MmgE_PrpD
498 amino acids: PaperBLAST, CDD, Compare to cluster

PRPD2_CORGL / Q8NSL3 2-methylcitrate dehydratase 2; 2-MC dehydratase; Aconitate hydratase; ACN; Aconitase; EC 4.2.1.79; EC 4.2.1.3 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
PFams: MmgE_PrpD
504 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

Q2L8W4 2-methylcitrate dehydratase (EC 4.2.1.79) from Toxoplasma gondii
PFams: MmgE_PrpD
521 amino acids: PaperBLAST, CDD