Clusters of Characterized Proteins

Clustering the characterized proteins for aldox-large ((glycol)aldehyde oxidoreductase, large subunit) in D-xylose catabolism

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Definition of aldox-large

• Curated sequence MONOMER-18071: glycolaldehyde oxidoreductase large subunit
• Curated sequence Q4J6M3: Glyceraldehyde dehydrogenase large chain; Glyceraldehyde dehydrogenase subunit A; Glyceraldehyde dehydrogenase subunit alpha; EC 1.2.99.8
• Ignore hits to items matching 1.2.99.8 when looking for 'other' hits
• Comment: glycolaldehyde oxidoreductase has multiple subunits and no EC number (Q97VI4, Q97VI7, Q97VI6). This is an inference from close homologs from S. acidocaldarius, which have demonstrated activity on glyceraldehyde-3-phosphate, glyceraldehyde, and acetaldehyde, but not on glycolaldehyde itself, so there's no proof that these genes provide the activity. Related enzymes in EC 1.2.99.8 are promiscuous, may well have this activity, so ignore.

Fetched 2 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 2 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 748-749 amino acids (heteromeric)

CUTA_SULAC / Q4J6M3 Glyceraldehyde dehydrogenase large chain; Glyceraldehyde dehydrogenase subunit A; Glyceraldehyde dehydrogenase subunit alpha; EC 1.2.99.8 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
PFams: Ald_Xan_dh_C, Ald_Xan_dh_C2
Heteromeric, 748 amino acids: PaperBLAST, CDD, Compare to cluster

Q97VI4 glycolaldehyde oxidoreductase large subunit from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
PFams: Ald_Xan_dh_C, Ald_Xan_dh_C2
Heteromeric, 749 amino acids: PaperBLAST, CDD, Compare to cluster