Clusters of Characterized Proteins

PaperBLAST – Find papers about a protein or its homologs

Clusters of Characterized Proteins

Searching for 4.2.1.17

Found 53 characterized proteins with matching descriptions. 13 of these are heteromeric.

Fetched 53 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 47 of these sequences

Found 8 clusters of similar sequences. Another 7 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 714-763 amino acids (5/16 heteromeric)

ECHP_RAT / P07896 Peroxisomal bifunctional enzyme; PBE; PBFE; EC 4.2.1.17; EC 5.3.3.8; EC 1.1.1.35 from Rattus norvegicus (Rat)
P07896 enoyl-CoA hydratase (EC 4.2.1.17) from Rattus norvegicus
RF|NP_598290.1 noyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase/3-hydroxyacyl-CoA dehydrogenase; EC 1.1.1.35; EC 4.2.1.17; EC 5.3.3.8 from Rattus norvegicus
PFams: ECH_1, ECH_2, 3HCDH_N, 3HCDH, 3HCDH
722 amino acids: PaperBLAST, CDD, Compare to cluster

ECHA_HUMAN / P40939 Trifunctional enzyme subunit alpha, mitochondrial; 78 kDa gastrin-binding protein; Monolysocardiolipin acyltransferase; TP-alpha; EC 2.3.1.-; EC 4.2.1.17; EC 1.1.1.211 from Homo sapiens (Human)
P40939 long-chain-3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211) from Homo sapiens
PFams: ECH_1, ECH_2, 3HCDH_N, 3HCDH, 3HCDH
Heteromeric, 763 amino acids: PaperBLAST, CDD, Compare to cluster

ECHA_RAT / Q64428 Trifunctional enzyme subunit alpha, mitochondrial; Monolysocardiolipin acyltransferase; TP-alpha; EC 2.3.1.-; EC 4.2.1.17; EC 1.1.1.211 from Rattus norvegicus (Rat)
Q64428 long-chain-3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211); acetyl-CoA C-acyltransferase (EC 2.3.1.16) from Rattus norvegicus
PFams: ECH_1, ECH_2, 3HCDH_N, 3HCDH, 3HCDH
Heteromeric, 763 amino acids: PaperBLAST, CDD, Compare to cluster

MFP2_ARATH / Q9ZPI5 Peroxisomal fatty acid beta-oxidation multifunctional protein MFP2; AtMPF2; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Arabidopsis thaliana (Mouse-ear cress)
Q9ZPI5 enoyl-CoA hydratase (EC 4.2.1.17) from Arabidopsis thaliana
PFams: ECH_1, ECH_2, 3HCDH_N, 3HCDH
725 amino acids: PaperBLAST, CDD, Compare to cluster

b2341 3-hydroxyacyl-CoA dehydrogenase FadJ (EC 1.1.1.35; EC 1.1.1.211; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8) from Escherichia coli K-12 substr. MG1655
P77399 3-hydroxyacyl-CoA dehydrogenase FadJ (EC 1.1.1.35; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8) from Escherichia coli (strain K12)
FADJ_ECOLI / P77399 Fatty acid oxidation complex subunit alpha; EC 4.2.1.17; EC 5.1.2.3; EC 1.1.1.35 from Escherichia coli (strain K12)
RF|NP_416843 fatty acid oxidation complex subunit alpha; EC 1.1.1.35; EC 4.2.1.17; EC 5.1.2.3 from Escherichia coli K12
PFams: ECH_1, ECH_2, 3HCDH_N, 3HCDH, 3HCDH
Heteromeric, 714 amino acids: PaperBLAST, CDD, Compare to cluster

b3846 dodecenoyl-CoA δ-isomerase, enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35; EC 1.1.1.211; EC 4.2.1.17; EC 5.3.3.8; EC 5.1.2.3) from Escherichia coli K-12 substr. MG1655
P21177 dodecenoyl-CoA δ-isomerase, enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35; EC 4.2.1.17; EC 5.3.3.8; EC 5.1.2.3) from Escherichia coli (strain K12)
FADB_ECOLI / P21177 Fatty acid oxidation complex subunit alpha; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Escherichia coli (strain K12)
PFams: ECH_1, ECH_2, 3HCDH_N, 3HCDH, 3HCDH
Heteromeric, 729 amino acids: PaperBLAST, CDD, Compare to cluster

FADB_PSEFR / P28793 Fatty acid oxidation complex subunit alpha; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Pseudomonas fragi
PFams: ECH_1, ECH_2, 3HCDH_N, 3HCDH
Heteromeric, 715 amino acids: PaperBLAST, CDD, Compare to cluster

Q08426 peroxisomal bifunctional enzyme (EC 4.2.1.17; EC 1.1.1.35) from Homo sapiens
ECHP_HUMAN / Q08426 Peroxisomal bifunctional enzyme; PBE; PBFE; EC 4.2.1.17; EC 5.3.3.8; EC 1.1.1.35 from Homo sapiens (Human)
PFams: ECH_1, ECH_2, 3HCDH_N, 3HCDH, 3HCDH
723 amino acids: PaperBLAST, CDD, Compare to cluster

MFPA_CUCSA / Q39659 Glyoxysomal fatty acid beta-oxidation multifunctional protein MFP-a; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Cucumis sativus (Cucumber)
PFams: ECH_1, ECH_2, 3HCDH_N, 3HCDH
725 amino acids: PaperBLAST, CDD, Compare to cluster

MFP_ORYSJ / Q8W1L6 Peroxisomal fatty acid beta-oxidation multifunctional protein; MFP; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Oryza sativa subsp. japonica (Rice)
PFams: ECH_1, ECH_2, 3HCDH_N, 3HCDH
726 amino acids: PaperBLAST, CDD, Compare to cluster

Q9ZPI6 peroxisomal fatty acid β-oxidation multifunctional protein AIM1 (EC 4.2.1.17) from Arabidopsis thaliana
AIM1_ARATH / Q9ZPI6 Peroxisomal fatty acid beta-oxidation multifunctional protein AIM1; Protein ABNORMAL INFLORESCENCE MERISTEM 1; AtAIM1; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Arabidopsis thaliana (Mouse-ear cress)
PFams: ECH_1, ECH_2, 3HCDH_N, 3HCDH
721 amino acids: PaperBLAST, CDD, Compare to cluster

Q88L02 FadB (EC 5.3.3.8; EC 1.1.1.35; EC 5.1.2.3; EC 4.2.1.17; EC 1.1.1.36) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
PFams: ECH_1, ECH_2, 3HCDH_N, 3HCDH
715 amino acids: PaperBLAST, CDD, Compare to cluster

Q9HZJ2 fatty acid oxidation complex α subunit (EC 1.1.1.35; EC 4.2.1.17) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PFams: ECH_1, ECH_2, 3HCDH_N, 3HCDH
715 amino acids: PaperBLAST, CDD, Compare to cluster

Shewana3_0024 Enoyl-CoA hydratase (EC 4.2.1.17); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) from Shewanella sp. ANA-3
PFams: ECH_1, ECH_2, 3HCDH_N, 3HCDH
716 amino acids: PaperBLAST, CDD, Compare to cluster

HP15_1512 Enoyl-CoA hydratase (EC 4.2.1.17) from Marinobacter adhaerens HP15
PFams: ECH_1, ECH_2, 3HCDH_N, 3HCDH
715 amino acids: PaperBLAST, CDD, Compare to cluster

Sama_0032 Enoyl-CoA hydratase (EC 4.2.1.17); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) from Shewanella amazonensis SB2B
PFams: ECH_1, ECH_2, 3HCDH_N, 3HCDH
716 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 254-296 amino acids (not heteromeric)

PAAF_ECOLI / P76082 2,3-dehydroadipyl-CoA hydratase; Enoyl-CoA hydratase; EC 4.2.1.17 from Escherichia coli (strain K12)
P76082 enoyl-CoA hydratase (EC 4.2.1.17) from Escherichia coli
PFams: ECH_1, ECH_2
255 amino acids: PaperBLAST, CDD, Compare to cluster

ECHM_RAT / P14604 Enoyl-CoA hydratase, mitochondrial; Enoyl-CoA hydratase 1; Short-chain enoyl-CoA hydratase; SCEH; EC 4.2.1.17 from Rattus norvegicus (Rat)
P14604 enoyl-CoA hydratase (EC 4.2.1.17); DELTA3,5-DELTA2,4-dienoyl-CoA isomerase (EC 5.3.3.21) from Rattus norvegicus
PFams: ECH_1, ECH_2
290 amino acids: PaperBLAST, CDD, Compare to cluster

P30084 mitochondrial enoyl-CoA hydratase (EC 4.2.1.17) from Homo sapiens
ECHM_HUMAN / P30084 Enoyl-CoA hydratase, mitochondrial; Enoyl-CoA hydratase 1; Short-chain enoyl-CoA hydratase; SCEH; EC 4.2.1.17 from Homo sapiens (Human)
P30084 enoyl-CoA hydratase (EC 4.2.1.17) from Homo sapiens
PFams: ECH_1, ECH_2
290 amino acids: PaperBLAST, CDD, Compare to cluster

Q9I5I4 enoyl-CoA hydratase (EC 4.2.1.17) from Pseudomonas aeruginosa
PFams: ECH_1, ECH_2
272 amino acids: PaperBLAST, CDD, Compare to cluster

DPGD_AMYOR / G4V4T7 Enoyl-CoA-hydratase; EC 4.2.1.17 from Amycolatopsis orientalis (Nocardia orientalis)
PFams: ECH_1, ECH_2
265 amino acids: PaperBLAST, CDD, Compare to cluster

ECH14_MYCBO / P64019 Probable enoyl-CoA hydratase echA14; EC 4.2.1.17 from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
PFams: ECH_1, ECH_2
256 amino acids: PaperBLAST, CDD, Compare to cluster

FADB_BACSU / P94549 Probable enoyl-CoA hydratase; EC 4.2.1.17 from Bacillus subtilis (strain 168)
PFams: ECH_1, ECH_2
258 amino acids: PaperBLAST, CDD, Compare to cluster

FER4_USTMA / Q4PEN0 Enoyl-CoA isomerase/hydratase fer4; Fe-regulated protein 4; Ferrichrome A biosynthesis protein fer4; EC 4.2.1.17 from Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
PFams: ECH_1, ECH_2
274 amino acids: PaperBLAST, CDD, Compare to cluster

ACTT3_ALTAL / Q589W8 Enoyl-CoA hydratase ACTT3; ACT-toxin biosynthesis protein 3; EC 4.2.1.17 from Alternaria alternata (Alternaria rot fungus) (Torula alternata)
PFams: ECH_1, ECH_2
296 amino acids: PaperBLAST, CDD, Compare to cluster

ECH17_MYCBO / Q7TXE1 Probable enoyl-CoA hydratase echA17; EC 4.2.1.17 from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
PFams: ECH_1, ECH_2
254 amino acids: PaperBLAST, CDD, Compare to cluster

AKT31_ALTAL / Q9P4U9 Enoyl-CoA hydratase AKT3-1; AF-toxin biosynthesis protein 3-1; EC 4.2.1.17 from Alternaria alternata (Alternaria rot fungus) (Torula alternata)
PFams: ECH_1, ECH_2
296 amino acids: PaperBLAST, CDD, Compare to cluster

Q58DM8 short chain enoyl-CoA hydratase subunit (EC 4.2.1.17) from Bos taurus
PFams: ECH_1, ECH_2
290 amino acids: PaperBLAST, CDD, Compare to cluster

Q845K2 2,3-dehydroadipyl-CoA hydratase (EC 4.2.1.17) from Pseudomonas sp. Y2
PFams: ECH_1, ECH_2
257 amino acids: PaperBLAST, CDD, Compare to cluster

BPHYT_RS17335 trans-2,3-dehydroadipyl-CoA hydratase (EC 4.2.1.17) from Burkholderia phytofirmans PsJN
PFams: ECH_1, ECH_2
258 amino acids: PaperBLAST, CDD, Compare to cluster

PP_3358 hydroxycinnamoyl-CoA hydratase-lyase (EC 4.2.1.17; EC 4.1.2.-) from Pseudomonas putida KT2440
PFams: ECH_1, ECH_2
276 amino acids: PaperBLAST, CDD, Compare to cluster

Psest_2437 Enoyl-CoA hydratase [valine degradation] (EC 4.2.1.17) from Pseudomonas stutzeri RCH2
PFams: ECH_1, ECH_2
257 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 415-569 amino acids (2/3 heteromeric)

A0A1C4WQE0 cis-L-3-hydroxyproline dehydratase (subunit 1/2) (EC 4.2.1.171) from Micromonospora viridifaciens
PFams: DUF521
Heteromeric, 428 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1S7J047 cis-L-3-hydroxyproline dehydratase (subunit 1/2) (EC 4.2.1.171) from Azospirillum brasilense
PFams: DUF521
Heteromeric, 415 amino acids: PaperBLAST, CDD, Compare to cluster

A9CH00 cis-L-3-hydroxyproline dehydratase (EC 4.2.1.171) from Agrobacterium tumefaciens
PFams: DUF126, DUF521
569 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 4 251-256 amino acids (heteromeric)

LEUD2_ARATH / Q9LYT7 3-isopropylmalate dehydratase small subunit 3; AtLEUD2; Isopropylmalate isomerase 1; Isopropylmalate isomerase small subunit 3; IPMI SSU3; EC 4.2.1.33 from Arabidopsis thaliana (Mouse-ear cress)
Q9LYT7 2-(omega-methylthio)alkylmalate dehydratase (subunit 1/2) (EC 4.2.1.170); 3-isopropylmalate dehydratase (EC 4.2.1.33) from Arabidopsis thaliana
PFams: Aconitase_C
Heteromeric, 253 amino acids: PaperBLAST, CDD, Compare to cluster

Q9ZW84 isopropylmalate isomerase, small subunit (EC 4.2.1.170) from Arabidopsis thaliana
LEUD1_ARATH / Q9ZW84 3-isopropylmalate dehydratase small subunit 2; AtLEUD1; Isopropylmalate isomerase 2; Isopropylmalate isomerase small subunit 2; IPMI SSU2; EC 4.2.1.33 from Arabidopsis thaliana (Mouse-ear cress)
Q9ZW84 3-isopropylmalate dehydratase (EC 4.2.1.33) from Arabidopsis thaliana
PFams: Aconitase_C
Heteromeric, 256 amino acids: PaperBLAST, CDD, Compare to cluster

Q9ZW85 isopropylmalate isomerase, small subunit (EC 4.2.1.33) from Arabidopsis thaliana
LEUD3_ARATH / Q9ZW85 3-isopropylmalate dehydratase small subunit 1; AtLEUD3; Isopropylmalate isomerase small subunit 1; IPMI SSU1; EC 4.2.1.33 from Arabidopsis thaliana (Mouse-ear cress)
Q9ZW85 2-(omega-methylthio)alkylmalate dehydratase (subunit 1/2) (EC 4.2.1.170); 3-isopropylmalate dehydratase (EC 4.2.1.33) from Arabidopsis thaliana
PFams: Aconitase_C
Heteromeric, 251 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 5 344-355 amino acids (not heteromeric)

Q9SE41 enoyl-CoA hydratase (EC 4.2.1.17) from Avicennia marina
PFams: ECH_2, ECH_1
344 amino acids: PaperBLAST, CDD, Compare to cluster

Q51969 enoyl-CoA hydratase subunit (EC 4.2.1.17) from Pseudomonas putida
PFams: ECH_1, ECH_2
355 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 6 296-296 amino acids (not heteromeric)

AFT31_ALTAL / Q96VB3 Enoyl-CoA hydratase AFT3-1; AF-toxin biosynthesis protein 3-1; EC 4.2.1.17 from Alternaria alternata (Alternaria rot fungus) (Torula alternata)
PFams: ECH_1, ECH_2
296 amino acids: PaperBLAST, CDD, Compare to cluster

AKT32_ALTAL / Q9P4U7 Enoyl-CoA hydratase AKT3-2; AK-toxin biosynthesis protein 3-2; EC 4.2.1.17 from Alternaria alternata (Alternaria rot fungus) (Torula alternata)
PFams: ECH_1, ECH_2
296 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 7 367-367 amino acids (not heteromeric)

C3HPD_LABAI / A0NXQ8 Cis-3-hydroxy-L-proline dehydratase; c3LHyp dehydratase; c3LHypD; EC 4.2.1.171 from Labrenzia aggregata (strain ATCC 25650 / DSM 13394 / JCM 20685 / NBRC 16684 / NCIMB 2208 / IAM 12614) (Stappia aggregata)
A0NXQ8 cis-L-3-hydroxyproline dehydratase (EC 4.2.1.171) from Labrenzia aggregata
PFams: MR_MLE_N, MR_MLE_C
367 amino acids: PaperBLAST, CDD, Compare to cluster

C3HPD_STAND / D7A0Y2 Cis-3-hydroxy-L-proline dehydratase; c3LHyp dehydratase; c3LHypD; EC 4.2.1.171 from Starkeya novella (strain ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB 9113)
PFams: MR_MLE_N, MR_MLE_C
367 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 8 789-789 amino acids (not heteromeric)

HYPD_CLODI / A0A031WDE4 Trans-4-hydroxy-L-proline dehydratase; Glycyl radical enzyme; Hyp dehydratase; EC 4.2.1.172 from Clostridioides difficile (Peptoclostridium difficile)
PFams: PFL-like, Gly_radical
789 amino acids: PaperBLAST, CDD, Compare to cluster

Q180C6 trans-4-hydroxy-L-proline dehydratase (EC 4.2.1.172) from Clostridioides difficile (strain 630)
PFams: PFL-like, Gly_radical
789 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (3/7 heteromeric)

A0A075FAK4 peregrinol diphosphate synthase (EC 4.2.1.174) from Marrubium vulgare
PFams: Terpene_synth, Terpene_synth_C
776 amino acids: PaperBLAST, CDD

A0A1C4WQP5 cis-L-3-hydroxyproline dehydratase (subunit 2/2) (EC 4.2.1.171) from Micromonospora viridifaciens
PFams: DUF126
Heteromeric, 150 amino acids: PaperBLAST, CDD

A0A1S7J048 cis-L-3-hydroxyproline dehydratase (subunit 2/2) (EC 4.2.1.171) from Azospirillum brasilense
PFams: DUF126
Heteromeric, 154 amino acids: PaperBLAST, CDD

Q0KEG0 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35); enoyl-CoA hydratase (EC 4.2.1.17) from Cupriavidus necator
PFams: 3HCDH_N, 3HCDH, ECH_1, ECH_2
807 amino acids: PaperBLAST, CDD

Q94AR8 isopropylmalate isomerase large subunit (EC 4.2.1.33) from Arabidopsis thaliana
LEUC_ARATH / Q94AR8 3-isopropylmalate dehydratase large subunit, chloroplastic; AtLEUC; Isopropylmalate isomerase large subunit 1; AtIIL1; IPMI LSU1; EC 4.2.1.33 from Arabidopsis thaliana (Mouse-ear cress)
Q94AR8 2-(omega-methylthio)alkylmalate dehydratase (subunit 2/2) (EC 4.2.1.170); 3-isopropylmalate dehydratase (EC 4.2.1.33) from Arabidopsis thaliana
PFams: Aconitase
Heteromeric, 509 amino acids: PaperBLAST, CDD

Q9I485 cis-L-3-hydroxyproline dehydratase (EC 4.2.1.171) from Pseudomonas aeruginosa
PFams: DUF126, DUF521
580 amino acids: PaperBLAST, CDD
(similar to BRENDA::A9CH00 from Cluster 3, but similarity to seed sequence is below thresholds)

DPGB_AMYOR / G4V4T5 Enoyl-CoA-hydratase; EC 4.2.1.17 from Amycolatopsis orientalis (Nocardia orientalis)
217 amino acids: PaperBLAST, CDD