Clusters of Characterized Proteins

Clustering the characterized proteins for argC (N-acylglutamylphosphate reductase) in L-arginine biosynthesis

Or see other characterized proteins similar to argC

Or see all steps for L-arginine biosynthesis

Or cluster curated proteins matching a keyword

Definition of argC

• Curated proteins or TIGRFams with EC 1.2.1.38
• Curated proteins matching N-succinylglutamylphosphate reductase
• Curated sequence CH_123299: arginine biosynthetic enzyme activities
• UniProt sequence E4PLW0: RecName: Full=N-acetyl-gamma-glutamyl-phosphate reductase {ECO:0000256|HAMAP-Rule:MF_00150}; Short=AGPR {ECO:0000256|HAMAP-Rule:MF_00150}; EC=1.2.1.38 {ECO:0000256|HAMAP-Rule:MF_00150}; AltName: Full=N-acetyl-glutamate semialdehyde dehydrogenase {ECO:0000256|HAMAP-Rule:MF_00150}; Short=NAGSA dehydrogenase {ECO:0000256|HAMAP-Rule:MF_00150};
• Comment: ArgC includes Bacteroides proteins that probably act on N-succinylglutamylphosphate instead of N-acetylglutamylphosphate (i.e. BT3759). CH_123299 has a broader annotation but probably has this activity. HP15_352 (E4PLW0) from Marinobacter adhaerens HP15 is important for fitness in most minimal media, unless arginine is provided.

Fetched 19 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 18 of these sequences

Found 3 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by cluster

Arabidopsis thaliana

ARGC_ARATH / Q93Z70 Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplastic; AGPR; N-acetyl-glutamate semialdehyde dehydrogenase; NAGSA dehydrogenase; EC 1.2.1.38 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Semialdhyde_dh, Semialdhyde_dhC
401 amino acids: PaperBLAST, CDD (Cluster 1)

Bacteroides thetaiotaomicron

BT3759 N-succinylglutamylphosphate reductase (EC 1.2.1.-) from Bacteroides thetaiotaomicron VPI-5482
PFams: Semialdhyde_dh, Semialdhyde_dhC
322 amino acids: PaperBLAST, CDD (Cluster 1)

Candida albicans

CH_123299 arginine biosynthetic enzyme activities from Candida albicans
PFams: AA_kinase, NAT, Semialdhyde_dh
857 amino acids: PaperBLAST, CDD (Cluster 2)

Dyella japonica

N515DRAFT_3769 N-acetylglutamylphosphate reductase (EC 1.2.1.38) from Dyella japonica UNC79MFTsu3.2
PFams: Semialdhyde_dh
319 amino acids: PaperBLAST, CDD (Cluster 1)

Echinicola vietnamensis

Echvi_3847 N-succinylglutamylphosphate reductase (EC 1.2.1.-) from Echinicola vietnamensis KMM 6221, DSM 17526
PFams: Semialdhyde_dh, Semialdhyde_dhC
322 amino acids: PaperBLAST, CDD (Cluster 1)

Escherichia coli

b3958 N-acetylglutamylphosphate reductase (EC 1.2.1.38) from Escherichia coli K-12 substr. MG1655
P11446 N-acetylglutamylphosphate reductase (EC 1.2.1.38) from Escherichia coli (strain K12)
ARGC_ECOLI / P11446 N-acetyl-gamma-glutamyl-phosphate reductase; AGPR; N-acetyl-glutamate semialdehyde dehydrogenase; NAGSA dehydrogenase; EC 1.2.1.38 from Escherichia coli (strain K12)
P11446 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) from Escherichia coli
PFams: Semialdhyde_dh, Semialdhyde_dhC
334 amino acids: PaperBLAST, CDD (Cluster 1)

Geobacillus stearothermophilus

ARGC_GEOSE / Q07906 N-acetyl-gamma-glutamyl-phosphate reductase; AGPR; N-acetyl-glutamate semialdehyde dehydrogenase; NAGSA dehydrogenase; EC 1.2.1.38 from Geobacillus stearothermophilus (Bacillus stearothermophilus)
PFams: Semialdhyde_dh, Semialdhyde_dhC
345 amino acids: PaperBLAST, CDD (Cluster 1)

Mycobacterium tuberculosis

P9WPZ9 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) from Mycobacterium tuberculosis
PFams: Semialdhyde_dh, Semialdhyde_dhC
352 amino acids: PaperBLAST, CDD (Cluster 1)

Organism unknown

E4PLW0 N-acetyl-gamma-glutamyl-phosphate reductase {ECO:0000256|HAMAP-Rule:MF_00150}; Short=AGPR {ECO:0000256|HAMAP-Rule:MF_00150}; EC=1.2.1.38 {ECO:0000256|HAMAP-Rule:MF_00150}; N-acetyl-glutamate semialdehyde dehydrogenase {ECO:0000256|HAMAP-Rule:MF_00150}; Short=NAGSA dehydrogenase {ECO:0000256|HAMAP-Rule:MF_00150}
388 amino acids: PaperBLAST, CDD (Cluster 1)

Oryza sativa

ARGC_ORYSJ / Q6AV34 Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplastic; AGPR; N-acetyl-glutamate semialdehyde dehydrogenase; NAGSA dehydrogenase; EC 1.2.1.38 from Oryza sativa subsp. japonica (Rice)
PFams: Semialdhyde_dh, Semialdhyde_dhC
415 amino acids: PaperBLAST, CDD (Cluster 1)

Pedobacter GW460-11-11-14-LB5

CA265_RS18540 N-succinylglutamylphosphate reductase (EC 1.2.1.38) from Pedobacter sp. GW460-11-11-14-LB5
PFams: Semialdhyde_dh, Semialdhyde_dhC
326 amino acids: PaperBLAST, CDD (Cluster 1)

Saccharomyces cerevisiae

ARG56_YEAST / Q01217 Protein ARG5,6, mitochondrial; EC 1.2.1.38; EC 2.7.2.8 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Q01217 acetylglutamate kinase (EC 2.7.2.8) from Saccharomyces cerevisiae
PFams: AA_kinase, NAT, Semialdhyde_dh, Semialdhyde_dhC
863 amino acids: PaperBLAST, CDD (Cluster 2)

Schizosaccharomyces pombe

ARG56_SCHPO / P31318 Protein arg11, mitochondrial; EC 1.2.1.38; EC 2.7.2.8 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
GI|1204210 N-acetyl-gamma-glutamyl-phosphate reductase/acetylglutamate kinase; EC 1.2.1.38; EC 2.7.2.8 from Schizosaccharomyces pombe
PFams: AA_kinase, NAT, Semialdhyde_dh
885 amino acids: PaperBLAST, CDD (Cluster 2)

Sinorhizobium meliloti

SMc01801 N-acetylglutamylphosphate reductase (EC 1.2.1.38) from Sinorhizobium meliloti 1021
PFams: Semialdhyde_dh
310 amino acids: PaperBLAST, CDD (Cluster 3)

Sphingomonas koreensis

Ga0059261_0351 N-acetylglutamylphosphate reductase (EC 1.2.1.38) from Sphingomonas koreensis DSMZ 15582
PFams: Semialdhyde_dh
310 amino acids: PaperBLAST, CDD (Cluster 3)

Sulfolobus acidocaldarius

Q4JAQ3 [amino-group carrier protein]-L-2-aminoadipate/[amino-group carrier protein]-L-glutamate phosphate reductase (EC 1.2.1.103; EC 1.2.1.106) (from HMM only) from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Q4JAQ3 [amino-group carrier protein]-5-phospho-L-glutamate reductase (EC 1.2.1.106) from Sulfolobus acidocaldarius
PFams: Semialdhyde_dh, Semialdhyde_dhC
350 amino acids: PaperBLAST, CDD (Cluster 1)

Thermococcus kodakarensis

Q5JFW1 [amino-group carrier protein]-5-phospho-L-glutamate reductase (EC 1.2.1.106) (from HMM only) from Thermococcus kodakarensis
PFams: Semialdhyde_dh, Semialdhyde_dhC
330 amino acids: PaperBLAST, CDD (Cluster 1)

Thermus thermophilus

O50146 [amino-group carrier protein]-L-2-aminoadipate 6-phosphate reductase (EC 1.2.1.103) (from HMM only) from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
LYSY_THET2 / O50146 [LysW]-L-2-aminoadipate 6-phosphate reductase; EC 1.2.1.103 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
O50146 [amino group carrier protein]-6-phospho-L-2-aminoadipate reductase (EC 1.2.1.103); [amino-group carrier protein]-5-phospho-L-glutamate reductase (EC 1.2.1.106) from Thermus thermophilus
PFams: Semialdhyde_dh, Semialdhyde_dhC
344 amino acids: PaperBLAST, CDD (Cluster 1)

uncultured bacterium

C7ACH5 lysine racemase (EC 5.1.1.5) (low-coverage HMM hit) from uncultured bacterium
PFams: MR_MLE_N, Semialdhyde_dh
393 amino acids: PaperBLAST, CDD (Singleton 1)