Other Characterized Proteins Similar to aroA

Finding the characterized proteins for aroA (3-phosphoshikimate 1-carboxyvinyltransferase) in chorismate biosynthesis

Or see clustering for step aroA

Or see all steps for chorismate biosynthesis

Or cluster curated proteins matching a keyword

Definition of aroA

• Curated proteins or TIGRFams with EC 2.5.1.19
• UniProt sequence Q72EV5_DESVH: RecName: Full=3-phosphoshikimate 1-carboxyvinyltransferase {ECO:0000256|HAMAP-Rule:MF_00210}; EC=2.5.1.19 {ECO:0000256|HAMAP-Rule:MF_00210}; AltName: Full=5-enolpyruvylshikimate-3-phosphate synthase {ECO:0000256|HAMAP-Rule:MF_00210}; Short=EPSP synthase {ECO:0000256|HAMAP-Rule:MF_00210}; Short=EPSPS {ECO:0000256|HAMAP-Rule:MF_00210};
• UniProt sequence I9A2E3: RecName: Full=3-phosphoshikimate 1-carboxyvinyltransferase {ECO:0000256|HAMAP-Rule:MF_00210}; EC=2.5.1.19 {ECO:0000256|HAMAP-Rule:MF_00210}; AltName: Full=5-enolpyruvylshikimate-3-phosphate synthase {ECO:0000256|HAMAP-Rule:MF_00210}; Short=EPSP synthase {ECO:0000256|HAMAP-Rule:MF_00210}; Short=EPSPS {ECO:0000256|HAMAP-Rule:MF_00210};
• UniProt sequence L0FR45: RecName: Full=3-phosphoshikimate 1-carboxyvinyltransferase {ECO:0000256|ARBA:ARBA00012450}; EC=2.5.1.19 {ECO:0000256|ARBA:ARBA00012450}; AltName: Full=5-enolpyruvylshikimate-3-phosphate synthase {ECO:0000256|ARBA:ARBA00030046};
• Predicted: UniProt sequence G0EEF0: SubName: Full=EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) {ECO:0000313|EMBL:AEM37991.1};
• Comment: Add AroA from Desulfovibrio vulgaris (DVU0463) because it is a bit diverged, is conserved essential, and clusters with aromatic amino acid biosynthesis genes. HMPREF1058_RS13970 (I9A2E3) is cofit with chorismate synthase (Surya Tripathi); also, it is 71% identical to BT2186 / BT_RS11065, which can complement an aroA- strain of E. coli (Bradley Biggs). PYRFU_RS00635 (G0EEF0) from Pyrolobus fumarii is from this family, has similar active site residues (alignment to Q83E11 shows three conserved residues, and D315 => R331), and its closest homologs are in chorisomate synthesis operons (but, these are under 30% identity); it is probably the missing aroA.

Fetched 46 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 0 other characterized sequences. (Found 42 hits including self hits.)

There are also 1 HMM-only high-coverage hits.

HMM-only sequences

(Since these sequences' annotations are outside the definition for aroA, HMM hits that are over 40% similar to these sequences will be scored as moderate confidence.)

H9TE88 shimimate dehydratase/3,4-dihydroxycyclohexa-1,5-diene-1-carboxylate--CoA ligase from Streptomyces flaveolus
PFams: EPSP_synthase, AMP-binding, AMP-binding_C
998 amino acids: PaperBLAST, CDD