Other Characterized Proteins Similar to aroD

GapMind for Amino acid biosynthesis

Other Characterized Proteins Similar to aroD

Finding the characterized proteins for aroD (3-dehydroquinate dehydratase) in chorismate biosynthesis

Or see clustering for step aroD

Or see all steps for chorismate biosynthesis

Or cluster curated proteins matching a keyword

Definition of aroD

Curated proteins or TIGRFams with EC 4.2.1.10
Ignore hits to B9CK59 when looking for 'other' hits (3-dehydroquinate dehydratase (EC 4.2.1.10))
Ignore hits to items matching EC 1.1.1.24 when looking for 'other' hits
Ignore hits to items matching EC 1.1.1.25 when looking for 'other' hits
Ignore hits to items matching EC 1.1.1.282 when looking for 'other' hits
Predicted: UniProt sequence G0EDV3: RecName: Full=3-dehydroquinate dehydratase {ECO:0000256|ARBA:ARBA00012060}; EC=4.2.1.10 {ECO:0000256|ARBA:ARBA00012060};
Comment: B9CK59 may be misannotated in BRENDA. Several plant shikimate dehydrogenases may also be 3-dehydroquinate dehydratases (fusion proteins), so any similarity to shikimate dehydrogenase (EC 1.1.1.24 or 1.1.1.25 or 1.1.1.282) is ignored. PYRFU_RS04235 (G0EDV3) from Pyrolobus fumarii is diverged, especially at the C terminal part, but has conserved functional residues, and a homolog from Sedimentisphaera salicampi is fused to aroE, so it is probably the missing aroD.

Fetched 50 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 14 other characterized sequences. (Found 63 hits including self hits.)

Removing ignored items reduces this to 1 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for aroD.)

Q7BUF8 5-deoxy-5-amino-3-dehydroquinate dehydratase from Amycolatopsis mediterranei
PFams: DHquinase_II
163 amino acids: PaperBLAST, CDD, metacyc::MONOMER-20727
45% identical to

G8M0G7 3-dehydroquinate dehydratase (EC 4.2.1.10) from Acetivibrio clariflavus
PFams: DHquinase_II
142 amino acids: PaperBLAST, CDD

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for aroD.)

A0A3Q7IET9 quinate/shikimate dehydrogenase [NAD(P)+] (EC 1.1.1.282) from Solanum lycopersicum
PFams: DHquinase_I, Shikimate_dh_N, SDH_C
514 amino acids: PaperBLAST, CDD, BRENDA::A0A3Q7IET9
86% identical to

Q6PUG0 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Nicotiana tabacum
PFams: DHquinase_I, Shikimate_dh_N
521 amino acids: PaperBLAST, CDD

A0A168S2H6 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Vitis vinifera
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
531 amino acids: PaperBLAST, CDD, BRENDA::A0A168S2H6
82% identical to

A0A5H2WZU5 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Eucalyptus camaldulensis
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
532 amino acids: PaperBLAST, CDD

A0A168S2B8 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Vitis vinifera
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
519 amino acids: PaperBLAST, CDD, BRENDA::A0A168S2B8
77% identical to

A0A5H2X4C4 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Eucalyptus camaldulensis
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
538 amino acids: PaperBLAST, CDD

A0A3G3BK08 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Camellia sinensis
PFams: DHquinase_I, Shikimate_dh_N, SDH_C
519 amino acids: PaperBLAST, CDD, BRENDA::A0A3G3BK08
73% identical to

Q6PUG0 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Nicotiana tabacum
PFams: DHquinase_I, Shikimate_dh_N
521 amino acids: PaperBLAST, CDD

A0A0A0LQ48 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Cucumis sativus
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
542 amino acids: PaperBLAST, CDD, BRENDA::A0A0A0LQ48
74% identical to

A0A5H2X4C4 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Eucalyptus camaldulensis
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
538 amino acids: PaperBLAST, CDD

D7TUX1 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Vitis vinifera
PFams: DHquinase_I, Shikimate_dh_N, SDH_C
519 amino acids: PaperBLAST, CDD, BRENDA::D7TUX1
69% identical to

Q6PUG0 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Nicotiana tabacum
PFams: DHquinase_I, Shikimate_dh_N
521 amino acids: PaperBLAST, CDD

A0A5H2WXM2 quinate/shikimate dehydrogenase (NAD+) (EC 1.1.1.24) from Eucalyptus camaldulensis
PFams: DHquinase_I, Shikimate_dh_N, SDH_C
520 amino acids: PaperBLAST, CDD, BRENDA::A0A5H2WXM2
68% identical to

Q6PUG0 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Nicotiana tabacum
PFams: DHquinase_I, Shikimate_dh_N
521 amino acids: PaperBLAST, CDD

A0A5H2X0F8 quinate/shikimate dehydrogenase (NAD+) (EC 1.1.1.24) from Eucalyptus camaldulensis
PFams: DHquinase_I, Shikimate_dh_N, SDH_C
520 amino acids: PaperBLAST, CDD, BRENDA::A0A5H2X0F8
68% identical to

Q6PUG0 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Nicotiana tabacum
PFams: DHquinase_I, Shikimate_dh_N
521 amino acids: PaperBLAST, CDD

A0A5H2WVH6 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Eucalyptus camaldulensis
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
530 amino acids: PaperBLAST, CDD, BRENDA::A0A5H2WVH6
68% identical to

A0A5H2WZU5 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Eucalyptus camaldulensis
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
532 amino acids: PaperBLAST, CDD

A0A168S2G5 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Vitis vinifera
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
531 amino acids: PaperBLAST, CDD, BRENDA::A0A168S2G5
67% identical to

A0A5H2WZU5 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Eucalyptus camaldulensis
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
532 amino acids: PaperBLAST, CDD

A0A6P8EJ47 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Punica granatum
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, Sacchrp_dh_NADP, SDH_C
545 amino acids: PaperBLAST, CDD, BRENDA::A0A6P8EJ47
65% identical to

A0A5H2WZU5 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Eucalyptus camaldulensis
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
532 amino acids: PaperBLAST, CDD

A0A3Q7H2B2 quinate/shikimate dehydrogenase [NAD(P)+] (EC 1.1.1.282) from Solanum lycopersicum
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, SDH_C
568 amino acids: PaperBLAST, CDD, BRENDA::A0A3Q7H2B2
50% identical to

Q6PUG0 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Nicotiana tabacum
PFams: DHquinase_I, Shikimate_dh_N
521 amino acids: PaperBLAST, CDD

B9CK59 3-dehydroquinate dehydratase (EC 4.2.1.10) from Lancefieldella rimae
PFams: PTS_EIIB, DHquinase_II
294 amino acids: PaperBLAST, CDD, BRENDA::B9CK59
46% identical to

G8M0G7 3-dehydroquinate dehydratase (EC 4.2.1.10) from Acetivibrio clariflavus
PFams: DHquinase_II
142 amino acids: PaperBLAST, CDD