Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for aroE (shikimate dehydrogenase) in chorismate biosynthesis

Or see other characterized proteins similar to aroE

Or see all steps for chorismate biosynthesis

Or cluster curated proteins matching a keyword

Definition of aroE

Curated proteins or TIGRFams with EC 1.1.1.25
Curated proteins or TIGRFams with EC 1.1.1.282
UniProt sequence Q8A006_BACTN: SubName: Full=Shikimate 5-dehydrogenase {ECO:0000313|EMBL:AAO79320.1};
Comment: EC 1.1.1.282 is with NAD(P)H instead of NADPH. Manually add the B. theta gene (BT4215, Q8A006_BACTN) because it is diverged, is the only good candidate, and is essential in various Bacteroidetes

Fetched 36 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 35 of these sequences

Found 3 clusters of similar sequences. Another 2 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 248-291 amino acids (not heteromeric)

O27957 shikimate dehydrogenase (EC 1.1.1.25)
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
269 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1K3RIC7 shikimate dehydrogenase (EC 1.1.1.25)
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
272 amino acids: PaperBLAST, CDD, Compare to cluster

A4QB65 Quinate/shikimate dehydrogenase (NAD(+)); QSDH; EC 1.1.1.-; EC 1.1.1.24
A4QB65 shikimate dehydrogenase (EC 1.1.1.25); quinate/shikimate dehydrogenase (EC 1.1.1.282)
PFams: Shikimate_dh_N, SDH_C
283 amino acids: PaperBLAST, CDD, Compare to cluster

A4QEK4 shikimate dehydrogenase (EC 1.1.1.25)
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
276 amino acids: PaperBLAST, CDD, Compare to cluster

O67049 Shikimate dehydrogenase (NADP(+)); SD; SDH; EC 1.1.1.25
O67049 shikimate dehydrogenase (EC 1.1.1.25)
PFams: Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
269 amino acids: PaperBLAST, CDD, Compare to cluster

AROE-MONOMER shikimate dehydrogenase (EC 1.1.1.25)
P15770 Shikimate dehydrogenase (NADP(+)); SD; SDH; EC 1.1.1.25
P15770 shikimate dehydrogenase (EC 1.1.1.25)
AROE-MONOMER shikimate dehydrogenase (EC 1.1.1.25)
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
272 amino acids: PaperBLAST, CDD, Compare to cluster

P43876 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25
P43876 shikimate dehydrogenase (EC 1.1.1.25)
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
272 amino acids: PaperBLAST, CDD, Compare to cluster

Q56S04 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25
Q56S04 shikimate dehydrogenase (EC 1.1.1.25)
PFams: Shikimate_dh_N
263 amino acids: PaperBLAST, CDD, Compare to cluster

Q5HNV1 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25
Q5HNV1 shikimate dehydrogenase (EC 1.1.1.25)
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
269 amino acids: PaperBLAST, CDD, Compare to cluster

Q5SJF8 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25
Q5SJF8 shikimate dehydrogenase (EC 1.1.1.25)
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
263 amino acids: PaperBLAST, CDD, Compare to cluster

Q88GF6 shikimate dehydrogenase (EC 1.1.1.25); quinate/shikimate dehydrogenase (EC 1.1.1.282)
PFams: Shikimate_dh_N
273 amino acids: PaperBLAST, CDD, Compare to cluster

Q88IJ7 shikimate dehydrogenase (EC 1.1.1.25)
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
272 amino acids: PaperBLAST, CDD, Compare to cluster

Q88JP1 shikimate dehydrogenase (EC 1.1.1.25); quinate/shikimate dehydrogenase (EC 1.1.1.282)
PFams: Shikimate_dh_N
269 amino acids: PaperBLAST, CDD, Compare to cluster

Q88K85 shikimate dehydrogenase (EC 1.1.1.25); quinate/shikimate dehydrogenase (EC 1.1.1.282)
PFams: Shikimate_dh_N
282 amino acids: PaperBLAST, CDD, Compare to cluster

Q88RQ5 shikimate dehydrogenase (EC 1.1.1.25)
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
274 amino acids: PaperBLAST, CDD, Compare to cluster

Q9WYI1 shikimate dehydrogenase (EC 1.1.1.25)
PFams: Shikimate_dh_N, Shikimate_DH
253 amino acids: PaperBLAST, CDD, Compare to cluster

Q9X5C9 Quinate/shikimate dehydrogenase (NAD(+)); QSDH; EC 1.1.1.-; EC 1.1.1.24
Q9X5C9 quinate dehydrogenase (EC 1.1.1.24); quinate/shikimate dehydrogenase (EC 1.1.1.282)
PFams: Shikimate_dh_N, SDH_C
283 amino acids: PaperBLAST, CDD, Compare to cluster

EG11234-MONOMER shikimate dehydrogenase / quinate dehydrogenase (EC 1.1.1.282)
P0A6D5 Quinate/shikimate dehydrogenase; NAD-dependent shikimate 5-dehydrogenase; EC 1.1.1.282
EG11234-MONOMER shikimate dehydrogenase / quinate dehydrogenase (EC 1.1.1.282)
CH_024574 quinate/shikimate dehydrogenase; EC 1.1.1.282
PFams: Shikimate_dh_N, SDH_C
288 amino acids: PaperBLAST, CDD, Compare to cluster

P44774 Shikimate dehydrogenase-like protein HI_0607; SDH-L; EC 1.1.1.25
PFams: Shikimate_dh_N
271 amino acids: PaperBLAST, CDD, Compare to cluster

P56119 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25
PFams: Shikimate_dh_N
263 amino acids: PaperBLAST, CDD, Compare to cluster

Q58484 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
282 amino acids: PaperBLAST, CDD, Compare to cluster

Q5KWX7 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
276 amino acids: PaperBLAST, CDD, Compare to cluster

Q8Y9N5 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25
PFams: Shikimate_dh_N, SDH_C
291 amino acids: PaperBLAST, CDD, Compare to cluster

Q9KVT3 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
278 amino acids: PaperBLAST, CDD, Compare to cluster

Q8A006_BACTN Shikimate 5-dehydrogenase
248 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 519-603 amino acids (not heteromeric)

A0A168S2B8 shikimate dehydrogenase (EC 1.1.1.25)
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, SDH_C
519 amino acids: PaperBLAST, CDD, Compare to cluster

A0A168S2G5 shikimate dehydrogenase (EC 1.1.1.25)
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, SDH_C
531 amino acids: PaperBLAST, CDD, Compare to cluster

A0A168S2H6 shikimate dehydrogenase (EC 1.1.1.25)
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
531 amino acids: PaperBLAST, CDD, Compare to cluster

D7TUX1 shikimate dehydrogenase (EC 1.1.1.25)
PFams: DHquinase_I, Shikimate_dh_N, SDH_C
519 amino acids: PaperBLAST, CDD, Compare to cluster

Q6PUF9 shikimate dehydrogenase (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10)
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored
569 amino acids: PaperBLAST, CDD, Compare to cluster

Q6PUG0 shikimate dehydrogenase (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10)
PFams: DHquinase_I, Shikimate_dh_N, SDH_C
521 amino acids: PaperBLAST, CDD, Compare to cluster

Q9SQT8 Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic; DHQ-SDH protein; DHQase-SORase; Protein EMBRYO DEFECTIVE 3004; EC 4.2.1.10; EC 1.1.1.25
Q9SQT8 3-dehydroquinate dehydratase (EC 4.2.1.10)
AT3G06350-MONOMER shikimate dehydrogenase (EC 1.1.1.25; EC 4.2.1.10)
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, IlvN, F420_oxidored, FAD_binding_2, SDH_C
603 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 1583-1588 amino acids (not heteromeric)

P07547 Pentafunctional AROM polypeptide; EC 4.2.3.4; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 1.1.1.25
P07547 shikimate dehydrogenase (EC 1.1.1.25)
CH_122161 pentafunctional AROM polypeptide; EC 1.1.1.25; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 4.2.3.4
PFams: Fe-ADH_2, DHQ_synthase, EPSP_synthase, SKI, DHquinase_I, Shikimate_dh_N, SDH_C
1583 amino acids: PaperBLAST, CDD, Compare to cluster

P08566 Pentafunctional AROM polypeptide; EC 4.2.3.4; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 1.1.1.25
YDR127W-MONOMER pentafunctional AROM polypeptide (EC 4.2.3.4; EC 1.1.1.25; EC 2.7.1.71; EC 2.5.1.19; EC 4.2.1.10)
PFams: DHQ_synthase, EPSP_synthase, SKI, DHquinase_I, Shikimate_dh_N, Shikimate_DH, SDH_C
1588 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/2 heteromeric)

P95001 shikimate dehydrogenase (EC 1.1.1.25)
PFams: Shikimate_dh_N, SDH_C
269 amino acids: PaperBLAST, CDD
(similar to BRENDA::A4QEK4 from Cluster 1, but similarity to seed sequence is below thresholds)

Q6W3D0 shikimate dehydrogenase (EC 1.1.1.25)
PFams: DHQ_synthase, DHQ_synthase, EPSP_synthase, EPSP_synthase, SKI, DHquinase_I, Shikimate_dh_N
3332 amino acids: PaperBLAST, CDD