Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for aroG (3-deoxy-7-phosphoheptulonate synthase) in chorismate biosynthesis

Or see other characterized proteins similar to aroG

Or see all steps for chorismate biosynthesis

Or cluster curated proteins matching a keyword

Definition of aroG

Curated proteins or TIGRFams with EC 2.5.1.54
Curated sequence P39912: 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54); chorismate mutase (EC 5.4.99.5)
Curated sequence CH_123440: 3-Deoxy-D-arabinoheptulosonate-7-phosphate synthase
Curated sequence CA265_RS11635: chorismate mutase (EC 5.4.99.5)
Ignore hits to items matching EC 4.1.2.15 when looking for 'other' hits
Ignore hits to C9K7C8 when looking for 'other' hits (Phospho-2-dehydro-3-deoxyheptonate aldolase AMT16; AM-toxin biosynthesis protein 16; EC 2.5.1.54)
Comment: This is also known as DAHP (3-deoxy-D-arabino-heptulosonate 7-phosphate) synthase. Add CA265_RS11635 (a fusion with chorismate mutase) because it is diverged, is confirmed by cofitness, and is essential in other Bacteroidetes. P39912 (Bacillus subtilis aroA) is annotated in BRENDA as chorismate mutase but it also has this activity (PMC1198938). CH_123440 is annotated as this but without the EC number. 4.1.2.15 is an obsolete EC number, but it appears in a few entries, so is ignored. C9K7C8 is annotated as this in SwissProt but its function is uncertain, so it is ignored.

Fetched 23 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 22 of these sequences

Found 4 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 272-372 amino acids (not heteromeric)

b0754 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive (EC 2.5.1.54) from Escherichia coli K-12 substr. MG1655
P0AB91 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive (EC 2.5.1.54) from Escherichia coli (strain K12)
C3TIE2 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from Escherichia coli
PFams: DAHP_synth_1
350 amino acids: PaperBLAST, CDD, Compare to cluster

b2601 3-deoxy-7-phosphoheptulonate synthase, Tyr-sensitive (EC 2.5.1.54) from Escherichia coli K-12 substr. MG1655
P00888 3-deoxy-7-phosphoheptulonate synthase, Tyr-sensitive (EC 2.5.1.54) from Escherichia coli (strain K12)
P00888 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from Escherichia coli
PFams: DAHP_synth_1
356 amino acids: PaperBLAST, CDD, Compare to cluster

P35170 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from Corynebacterium glutamicum
PFams: DAHP_synth_1
366 amino acids: PaperBLAST, CDD, Compare to cluster

Q9K169 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from Neisseria meningitidis
PFams: DAHP_synth_1
351 amino acids: PaperBLAST, CDD, Compare to cluster

GB|AAB48240.1 phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited; EC 2.5.1.54 from Candida albicans
PFams: DAHP_synth_1
370 amino acids: PaperBLAST, CDD, Compare to cluster

CH_123440 3-Deoxy-D-arabinoheptulosonate-7-phosphate synthase from Candida albicans
PFams: DAHP_synth_1
272 amino acids: PaperBLAST, CDD, Compare to cluster

AROF_YEAST / P14843 Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; DAHP synthase; Phospho-2-keto-3-deoxyheptonate aldolase; EC 2.5.1.54 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: DAHP_synth_1
370 amino acids: PaperBLAST, CDD, Compare to cluster

AROG_YEAST / P32449 Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; DAHP synthase; Phospho-2-keto-3-deoxyheptonate aldolase; EC 2.5.1.54 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: DAHP_synth_1
370 amino acids: PaperBLAST, CDD, Compare to cluster

AROG_SCHPO / Q9UT09 Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; DAHP synthase; Phospho-2-keto-3-deoxyheptonate aldolase; EC 2.5.1.54 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
PFams: DAHP_synth_1
372 amino acids: PaperBLAST, CDD, Compare to cluster

b1704 3-deoxy-7-phosphoheptulonate synthase, Trp-sensitive (EC 2.5.1.54) from Escherichia coli K-12 substr. MG1655
P00887 3-deoxy-7-phosphoheptulonate synthase, Trp-sensitive (EC 2.5.1.54) from Escherichia coli (strain K12)
PFams: DAHP_synth_1
348 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 405-539 amino acids (not heteromeric)

A0A0D5ZBC4 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from Gossypium hirsutum
PFams: DAHP_synth_2
539 amino acids: PaperBLAST, CDD, Compare to cluster

G3XCJ9 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from Pseudomonas aeruginosa
PFams: DAHP_synth_2, DAHP_synth_2
405 amino acids: PaperBLAST, CDD, Compare to cluster

AROG_MYCTU / O53512 Phospho-2-dehydro-3-deoxyheptonate aldolase AroG; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; DAHP synthase; Phospho-2-keto-3-deoxyheptonate aldolase; EC 2.5.1.54 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
O53512 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from Mycobacterium tuberculosis
PFams: DAHP_synth_2
462 amino acids: PaperBLAST, CDD, Compare to cluster

O68903 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from Actinosynnema pretiosum subsp. auranticum
PFams: DAHP_synth_2
455 amino acids: PaperBLAST, CDD, Compare to cluster

P29976 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from Arabidopsis thaliana
PFams: DAHP_synth_2
525 amino acids: PaperBLAST, CDD, Compare to cluster

AROG2_PETHY / A0A067XGX8 Phospho-2-dehydro-3-deoxyheptonate aldolase 2, chloroplastic; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase 2; DAHP synthase 2; PhDAHP2; Phospho-2-keto-3-deoxyheptonate aldolase 2; EC 2.5.1.54 from Petunia hybrida (Petunia)
PFams: DAHP_synth_2
512 amino acids: PaperBLAST, CDD, Compare to cluster

AROG1_PETHY / A0A067XH53 Phospho-2-dehydro-3-deoxyheptonate aldolase 1, chloroplastic; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase 1; DAHP synthase 1; PhDAHP1; Phospho-2-keto-3-deoxyheptonate aldolase 1; EC 2.5.1.54 from Petunia hybrida (Petunia)
PFams: DAHP_synth_2
533 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 270-338 amino acids (not heteromeric)

Q9YEJ7 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from Aeropyrum pernix
PFams: DAHP_synth_1, NeuB
270 amino acids: PaperBLAST, CDD, Compare to cluster

A0A482F152 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from uncultured bacterium
PFams: DAHP_synth_1, NeuB
272 amino acids: PaperBLAST, CDD, Compare to cluster

Q9WYH8 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from Thermotoga maritima
PFams: DAHP_snth_FXD, DAHP_synth_1, NeuB
338 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 4 367-379 amino acids (not heteromeric)

Echvi_0120 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase / chorismate mutase (EC 2.5.1.54; EC 5.4.99.5) from Echinicola vietnamensis KMM 6221, DSM 17526
PFams: DAHP_synth_1, CM_2
367 amino acids: PaperBLAST, CDD, Compare to cluster

CA265_RS11635 chorismate mutase (EC 5.4.99.5) from Pedobacter sp. GW460-11-11-14-LB5
PFams: DAHP_synth_1, CM_2
379 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

P39912 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54); chorismate mutase (EC 5.4.99.5) from Bacillus subtilis
PFams: CM_2, DAHP_synth_1, NeuB
358 amino acids: PaperBLAST, CDD