Clusters of Characterized Proteins

Clustering the characterized proteins for aroG (3-deoxy-7-phosphoheptulonate synthase) in chorismate biosynthesis

Or see other characterized proteins similar to aroG

Or see all steps for chorismate biosynthesis

Or cluster curated proteins matching a keyword

Definition of aroG

• Curated proteins or TIGRFams with EC 2.5.1.54
• UniProt sequence L0FSZ3_ECHVK: SubName: Full=3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase {ECO:0000313|EMBL:AGA76417.1};
• Ignore hits to items matching EC 4.1.2.15 when looking for 'other' hits
• Comment: 4.1.2.15 is an obsolete EC number, but it appears in a few entries. This is also known as DAHP (3-deoxy-D-arabino-heptulosonate 7-phosphate) synthase . Add Echvi_0120 because it is diverged, is confirmed by cofitness, and is essential in other Bacteroidetes. (Echvi_0120 is a fusion with chorismate mutase.)

Fetched 19 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 18 of these sequences

Found 3 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 272-374 amino acids (not heteromeric)

AROG-MONOMER 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive (EC 2.5.1.54)
P0AB91 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54)
AROG-MONOMER 2-dehydro-3-deoxyphosphoheptonate aldolase (EC 2.5.1.54)
PFams: DAHP_synth_1
350 amino acids: PaperBLAST, CDD, Compare to cluster

P35170 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54)
PFams: DAHP_synth_1
366 amino acids: PaperBLAST, CDD, Compare to cluster

Q9K169 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54)
PFams: DAHP_synth_1
351 amino acids: PaperBLAST, CDD, Compare to cluster

CH_123343 phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited; EC 2.5.1.54
PFams: DAHP_synth_1
370 amino acids: PaperBLAST, CDD, Compare to cluster

CH_123440 3-Deoxy-D-arabinoheptulosonate-7-phosphate synthase (low-coverage HMM hit)
PFams: DAHP_synth_1
272 amino acids: PaperBLAST, CDD, Compare to cluster

C9K7C8 Phospho-2-dehydro-3-deoxyheptonate aldolase AMT16; AM-toxin biosynthesis protein 16; EC 2.5.1.54
PFams: DAHP_synth_1
374 amino acids: PaperBLAST, CDD, Compare to cluster

P14843 Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; DAHP synthase; Phospho-2-keto-3-deoxyheptonate aldolase; EC 2.5.1.54
PFams: DAHP_synth_1
370 amino acids: PaperBLAST, CDD, Compare to cluster

P32449 Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; DAHP synthase; Phospho-2-keto-3-deoxyheptonate aldolase; EC 2.5.1.54
PFams: DAHP_synth_1
370 amino acids: PaperBLAST, CDD, Compare to cluster

Q9UT09 Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; DAHP synthase; Phospho-2-keto-3-deoxyheptonate aldolase; EC 2.5.1.54
PFams: DAHP_synth_1
372 amino acids: PaperBLAST, CDD, Compare to cluster

AROF-MONOMER 3-deoxy-7-phosphoheptulonate synthase, Tyr-sensitive (EC 2.5.1.54)
AROF-MONOMER 2-dehydro-3-deoxyphosphoheptonate aldolase (EC 2.5.1.54)
PFams: DAHP_synth_1
356 amino acids: PaperBLAST, CDD, Compare to cluster

AROH-MONOMER 3-deoxy-7-phosphoheptulonate synthase, Trp-sensitive (EC 2.5.1.54)
AROH-MONOMER 2-dehydro-3-deoxyphosphoheptonate aldolase (EC 2.5.1.54)
PFams: DAHP_synth_1
348 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 455-539 amino acids (not heteromeric)

A0A0D5ZBC4 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54)
PFams: DAHP_synth_2
539 amino acids: PaperBLAST, CDD, Compare to cluster

O53512 Phospho-2-dehydro-3-deoxyheptonate aldolase AroG; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; DAHP synthase; Phospho-2-keto-3-deoxyheptonate aldolase; EC 2.5.1.54
O53512 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54)
PFams: DAHP_synth_2
462 amino acids: PaperBLAST, CDD, Compare to cluster

O68903 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54)
PFams: DAHP_synth_2
455 amino acids: PaperBLAST, CDD, Compare to cluster

P29976 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54)
PFams: DAHP_synth_2
525 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 262-338 amino acids (not heteromeric)

Q8U0A9 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54)
PFams: DAHP_synth_1, NeuB
262 amino acids: PaperBLAST, CDD, Compare to cluster

Q9WYH8 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54)
PFams: DAHP_snth_FXD, DAHP_synth_1, NeuB
338 amino acids: PaperBLAST, CDD, Compare to cluster

Q9YEJ7 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54)
PFams: DAHP_synth_1, NeuB
270 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

L0FSZ3_ECHVK 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase
367 amino acids: PaperBLAST, CDD