Other Characterized Proteins Similar to aroG

Finding the characterized proteins for aroG (3-deoxy-7-phosphoheptulonate synthase) in chorismate biosynthesis

Or see clustering for step aroG

Or see all steps for chorismate biosynthesis

Or cluster curated proteins matching a keyword

Definition of aroG

• Curated proteins or TIGRFams with EC 2.5.1.54
• Curated sequence P39912: 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54); chorismate mutase (EC 5.4.99.5)
• Curated sequence CH_123440: 3-Deoxy-D-arabinoheptulosonate-7-phosphate synthase
• Curated sequence CA265_RS11635: chorismate mutase (EC 5.4.99.5)
• Ignore hits to items matching EC 4.1.2.15 when looking for 'other' hits
• Ignore hits to C9K7C8 when looking for 'other' hits (Phospho-2-dehydro-3-deoxyheptonate aldolase AMT16; AM-toxin biosynthesis protein 16; EC 2.5.1.54)
• Comment: This is also known as DAHP (3-deoxy-D-arabino-heptulosonate 7-phosphate) synthase. Add CA265_RS11635 (a fusion with chorismate mutase) because it is diverged, is confirmed by cofitness, and is essential in other Bacteroidetes. P39912 (Bacillus subtilis aroA) is annotated in BRENDA as chorismate mutase but it also has this activity (PMC1198938). CH_123440 is annotated as this but without the EC number. 4.1.2.15 is an obsolete EC number, but it appears in a few entries, so is ignored. C9K7C8 is annotated as this in SwissProt but its function is uncertain, so it is ignored.

Fetched 23 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 2 other characterized sequences. (Found 25 hits including self hits.)

Removing ignored items reduces this to 0 close sequences.

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for aroG.)

CH_122323 phe-inhibited DAHP synthase; EC 4.1.2.15 from Emericella nidulans
PFams: DAHP_synth_1
374 amino acids: PaperBLAST, CDD, CharProtDB::CH_122323
73% identical to

CH_123440 3-Deoxy-D-arabinoheptulosonate-7-phosphate synthase from Candida albicans
PFams: DAHP_synth_1
272 amino acids: PaperBLAST, CDD

AMT16_ALTAL / C9K7C8 Phospho-2-dehydro-3-deoxyheptonate aldolase AMT16; AM-toxin biosynthesis protein 16; EC 2.5.1.54 from Alternaria alternata (Alternaria rot fungus) (Torula alternata)
PFams: DAHP_synth_1
374 amino acids: PaperBLAST, CDD, SwissProt::C9K7C8
70% identical to

CH_123440 3-Deoxy-D-arabinoheptulosonate-7-phosphate synthase from Candida albicans
PFams: DAHP_synth_1
272 amino acids: PaperBLAST, CDD