Other Characterized Proteins Similar to asp-kinase

Finding the characterized proteins for asp-kinase (aspartate kinase) in chorismate biosynthesis

Or see clustering for step asp-kinase

Or see all steps for chorismate biosynthesis

Or cluster curated proteins matching a keyword

Definition of asp-kinase

• Curated proteins or TIGRFams with EC 2.7.2.4
• Ignore hits to O63067 when looking for 'other' hits (homoserine dehydrogenase (EC 1.1.1.3))
• Ignore hits to Q46133 when looking for 'other' hits (aspartate kinase (EC 2.7.2.4))
• Comment: For BRENDA::O63067 -- the paper describes a monofunctional hom but the sequence of O63067 is much longer and has a close homolog of functional aspartate kinase (due to alternative splicing?). In Corynebacterium, aspartate kinase has two subunits, both apparently encoded by the same gene by using start codons (PMID:1956296); Q46133 is the shorter regulatory subunit and lacks the catalytic domain, so it does not suffice for activity and is ignored.

Fetched 36 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 1 other characterized sequences. (Found 37 hits including self hits.)

Removing ignored items reduces this to 0 close sequences.

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for asp-kinase.)

O63067 homoserine dehydrogenase (EC 1.1.1.3) from Glycine max
PFams: AA_kinase, ACT_7, ACT, NAD_binding_3, Homoserine_dh
916 amino acids: PaperBLAST, CDD, BRENDA::O63067
76% identical to

AKH2_ARATH / O81852 Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic; AK-HD 2; AK-HSDH 2; Beta-aspartyl phosphate homoserine 2; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress)
PFams: AA_kinase, ACT_7, ACT, NAD_binding_3, Homoserine_dh
916 amino acids: PaperBLAST, CDD