Other Characterized Proteins Similar to CBS

GapMind for Amino acid biosynthesis

Other Characterized Proteins Similar to CBS

Finding the characterized proteins for CBS (cystathionine beta-synthase) in L-cysteine biosynthesis

Or see clustering for step CBS

Or see all steps for L-cysteine biosynthesis

Or cluster curated proteins matching a keyword

Definition of CBS

Curated proteins or TIGRFams with EC 4.2.1.22
Ignore hits to Q3TWN3 when looking for 'other' hits (cystathionine beta-synthase (EC 4.2.1.22). Metal transporter CNNM2; Ancient conserved domain-containing protein 2; mACDP2; Cyclin-M2)
Ignore hits to Q5SK23 when looking for 'other' hits (cystathionine beta-synthase (EC 4.2.1.22))
Ignore hits to Q9EYM7 when looking for 'other' hits (cysteine-S-conjugate beta-lyase (EC 4.4.1.13))
Ignore hits to HS04050-MONOMER when looking for 'other' hits (cystathionine gamma-lyase (EC 4.4.1.1). Cystathionine gamma-lyase; CGL; CSE; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase; EC 4.4.1.1; EC 4.4.1.2. cystathionine γ-lyase monomer (EC 4.4.1.1; EC 4.4.1.2; EC 4.2.1.22))
Comment: Q3TWN3 and Q5SK23 are misannotated in BRENDA. Q9EYM7 may well have this activity (PMID:12101301). Human CGL is given this EC number as well by metacyc (link), but is not expected to form cystathionine from serine + homocysteine.

Fetched 13 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 30 other characterized sequences. (Found 43 hits including self hits.)

Removing ignored items reduces this to 29 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for CBS.)

MCCA_BACSU / O05393 O-acetylserine dependent cystathionine beta-synthase; EC 2.5.1.134 from Bacillus subtilis (strain 168)
PFams: PALP
307 amino acids: PaperBLAST, CDD, SwissProt::O05393
56% identical to

F9UT54 cysteine synthase (EC 2.5.1.47); cystathionine beta-synthase (EC 4.2.1.22) from Lactiplantibacillus plantarum
PFams: PALP
303 amino acids: PaperBLAST, CDD

CYSK_BACSU / P37887 Cysteine synthase; CSase; O-acetylserine (thiol)-lyase; OAS-TL; Superoxide-inducible protein 11; SOI11; EC 2.5.1.47 from Bacillus subtilis (strain 168)
P37887 cysteine synthase (EC 2.5.1.47) from Bacillus subtilis
PFams: PALP
308 amino acids: PaperBLAST, CDD, BRENDA::P37887
45% identical to

P56067 cystathionine β-synthase (O-acetyl-L-serine) monomer (EC 4.2.1.22; EC 2.5.1.134; EC 2.5.1.47) from Helicobacter pylori (strain ATCC 700392 / 26695)
PFams: PALP
306 amino acids: PaperBLAST, CDD

Q9XEA8 cysteine synthase (EC 2.5.1.47) from Oryza sativa Japonica Group
PFams: PALP
325 amino acids: PaperBLAST, CDD, BRENDA::Q9XEA8
44% identical to

CAS1_SOLTU / Q76MX2 Bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial; EC 2.5.1.47; EC 4.4.1.9 from Solanum tuberosum (Potato)
Q76MX2 L-3-cyanoalanine synthase (EC 4.4.1.9) from Solanum tuberosum
PFams: PALP
351 amino acids: PaperBLAST, CDD, BRENDA::Q76MX2
43% identical to

P47998 O-acetylserine (thiol) lyase (EC 2.5.1.47) from Arabidopsis thaliana
CYSK1_ARATH / P47998 Cysteine synthase 1; At.OAS.5-8; Beta-substituted Ala synthase 1;1; ARAth-Bsas1;1; CSase A; AtCS-A; Cys-3A; O-acetylserine (thiol)-lyase 1; OAS-TL A; O-acetylserine sulfhydrylase; Protein ONSET OF LEAF DEATH 3; EC 2.5.1.47 from Arabidopsis thaliana (Mouse-ear cress)
PFams: PALP
322 amino acids: PaperBLAST, CDD, SwissProt::P47998
43% identical to

CYSK_MYCTU / P9WP55 O-acetylserine sulfhydrylase; OAS sulfhydrylase; OASS; Cysteine synthase A; CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine-specific cysteine synthase; Sulfide-dependent cysteine synthase; EC 2.5.1.47 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WP55 cysteine synthase (EC 2.5.1.47) from Mycobacterium tuberculosis
PFams: PALP
310 amino acids: PaperBLAST, CDD, BRENDA::P9WP55
43% identical to

F9UT54 cysteine synthase (EC 2.5.1.47); cystathionine beta-synthase (EC 4.2.1.22) from Lactiplantibacillus plantarum
PFams: PALP
303 amino acids: PaperBLAST, CDD

CGL_ARATH / F4K5T2 Bifunctional cystathionine gamma-lyase/cysteine synthase; Beta-substituted Ala synthase 4;3; ARAth-Bsas4;3; L-cysteine desulfhydrase 1; DES1; O-acetylserine (thiol)-lyase; OASTL; Protein CS-LIKE; EC 2.5.1.47; EC 4.4.1.1 from Arabidopsis thaliana (Mouse-ear cress)
F4K5T2 L-cysteine desulfidase (EC 4.4.1.28) from Arabidopsis thaliana
PFams: PALP
323 amino acids: PaperBLAST, CDD, BRENDA::F4K5T2
42% identical to

O81155 cysteine synthase (EC 2.5.1.47) from Solanum tuberosum
PFams: PALP
386 amino acids: PaperBLAST, CDD, BRENDA::O81155
42% identical to

CYSK_CITLA / Q43317 Cysteine synthase; CSase; Beta-PA/CSase; Beta-pyrazolylalanine synthase; L-mimosine synthase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase; EC 2.5.1.47; EC 2.5.1.51; EC 4.2.1.50; EC 2.5.1.52 from Citrullus lanatus (Watermelon) (Citrullus vulgaris)
PFams: PALP
325 amino acids: PaperBLAST, CDD, SwissProt::Q43317
42% identical to

A3RM03 cysteine synthase (EC 2.5.1.47) from Glycine max
PFams: PALP
325 amino acids: PaperBLAST, CDD, BRENDA::A3RM03
41% identical to

Q84IF9 cysteine synthase (EC 2.5.1.47); L-3-cyanoalanine synthase (EC 4.4.1.9) from Geobacillus stearothermophilus
PFams: PALP
308 amino acids: PaperBLAST, CDD, BRENDA::Q84IF9
42% identical to

A8YBS4 cysteine synthase (EC 2.5.1.47) from Microcystis aeruginosa
PFams: PALP
319 amino acids: PaperBLAST, CDD, BRENDA::A8YBS4
42% identical to

W5S3I4 cysteine synthase (EC 2.5.1.47) from Leucaena leucocephala
PFams: PALP
325 amino acids: PaperBLAST, CDD, BRENDA::W5S3I4
41% identical to

F9UT54 cysteine synthase (EC 2.5.1.47); cystathionine beta-synthase (EC 4.2.1.22) from Lactiplantibacillus plantarum
PFams: PALP
303 amino acids: PaperBLAST, CDD

A3RM06 cysteine synthase (EC 2.5.1.47) from Glycine max
PFams: PALP
324 amino acids: PaperBLAST, CDD, BRENDA::A3RM06
42% identical to

CYSD2_ARATH / Q9SXS7 Bifunctional L-3-cyanoalanine synthase/cysteine synthase D2; Beta-substituted Ala synthase 4;2; ARAth-Bsas4;2; Cysteine synthase D2; AtcysD2; O-acetylserine (thiol)-lyase 6; EC 2.5.1.47; EC 4.4.1.9 from Arabidopsis thaliana (Mouse-ear cress)
PFams: PALP
323 amino acids: PaperBLAST, CDD, SwissProt::Q9SXS7
41% identical to

F9UT54 cysteine synthase (EC 2.5.1.47); cystathionine beta-synthase (EC 4.2.1.22) from Lactiplantibacillus plantarum
PFams: PALP
303 amino acids: PaperBLAST, CDD

F5HTD7 cysteine synthase (EC 2.5.1.47) from Mimosa pudica
PFams: PALP
329 amino acids: PaperBLAST, CDD, BRENDA::F5HTD7
41% identical to

P47999 O-acetylserine (thiol) lyase (EC 2.5.1.47) from Arabidopsis thaliana
CYSKP_ARATH / P47999 Cysteine synthase, chloroplastic/chromoplastic; At.OAS.7-4; Beta-substituted Ala synthase 2;1; ARAth-Bsas2;1; CSase B; AtCS-B; CS-B; O-acetylserine (thiol)-lyase; O-acetylserine sulfhydrylase; OAS-TL B; cpACS1; EC 2.5.1.47 from Arabidopsis thaliana (Mouse-ear cress)
P47999 cysteine synthase (EC 2.5.1.47) from Arabidopsis thaliana
PFams: PALP
392 amino acids: PaperBLAST, CDD, BRENDA::P47999
42% identical to

O81154 cysteine synthase (EC 2.5.1.47) from Solanum tuberosum
PFams: PALP
325 amino acids: PaperBLAST, CDD, BRENDA::O81154
41% identical to

J9WJN8 L-cysteine desulfidase (EC 4.4.1.28) from Brassica napus
PFams: PALP
323 amino acids: PaperBLAST, CDD, BRENDA::J9WJN8
40% identical to

CYSC1_ARATH / Q9S757 Bifunctional L-3-cyanoalanine synthase/cysteine synthase C1, mitochondrial; Beta-substituted Ala synthase 3;1; ARAth-Bsas3;1; Cysteine synthase C1; AtCYSC1; O-acetylserine (thiol)-lyase 5; EC 2.5.1.47; EC 4.4.1.9 from Arabidopsis thaliana (Mouse-ear cress)
Q9S757 L-3-cyanoalanine synthase (EC 4.4.1.9) from Arabidopsis thaliana
PFams: PALP
368 amino acids: PaperBLAST, CDD, BRENDA::Q9S757
42% identical to

Q43725 O-acetylserine (thiol) lyase (EC 2.5.1.47) from Arabidopsis thaliana
CYSKM_ARATH / Q43725 Cysteine synthase, mitochondrial; Beta-substituted Ala synthase 2;2; ARAth-Bsas2;2; CSase C; AtCS-C; CS-C; O-acetylserine (thiol)-lyase; O-acetylserine sulfhydrylase; OAS-TL C; EC 2.5.1.47 from Arabidopsis thaliana (Mouse-ear cress)
Q43725 cysteine synthase (EC 2.5.1.47) from Arabidopsis thaliana
PFams: PALP
430 amino acids: PaperBLAST, CDD, BRENDA::Q43725
40% identical to

CAS2_SOLTU / Q9FS29 Bifunctional L-3-cyanoalanine synthase/cysteine synthase 2, mitochondrial; EC 2.5.1.47; EC 4.4.1.9 from Solanum tuberosum (Potato)
Q9FS29 L-3-cyanoalanine synthase (EC 4.4.1.9) from Solanum tuberosum
PFams: PALP
347 amino acids: PaperBLAST, CDD, SwissProt::Q9FS29
40% identical to

A0A2H5HU77 cysteine synthase (EC 2.5.1.47) from Lathyrus sativus
PFams: PALP
325 amino acids: PaperBLAST, CDD, BRENDA::A0A2H5HU77
40% identical to

CYSC_SPIOL / Q43153 Bifunctional L-3-cyanoalanine synthase/cysteine synthase, mitochondrial; Beta-cyanoalanine synthase; SoCAS; Beta-substituted Ala synthase 3-1; SPIol-Bsas3-1; Cysteine synthase C; EC 2.5.1.47; EC 4.4.1.9 from Spinacia oleracea (Spinach)
Q43153 L-3-cyanoalanine synthase (EC 4.4.1.9) from Spinacia oleracea
PFams: PALP
368 amino acids: PaperBLAST, CDD, SwissProt::Q43153
40% identical to

I1L6I6 L-3-cyanoalanine synthase (EC 4.4.1.9) from Glycine max
PFams: PALP
373 amino acids: PaperBLAST, CDD, BRENDA::I1L6I6
40% identical to

A8YBP8 cysteine synthase (EC 2.5.1.47) from Microcystis aeruginosa
PFams: PALP
315 amino acids: PaperBLAST, CDD, BRENDA::A8YBP8
40% identical to

F9UT54 cysteine synthase (EC 2.5.1.47); cystathionine beta-synthase (EC 4.2.1.22) from Lactiplantibacillus plantarum
PFams: PALP
303 amino acids: PaperBLAST, CDD

CYSK_SYNE7 / Q59966 Cysteine synthase; CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase; EC 2.5.1.47 from Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2)
PFams: PALP
329 amino acids: PaperBLAST, CDD, SwissProt::Q59966
40% identical to

F9UT54 cysteine synthase (EC 2.5.1.47); cystathionine beta-synthase (EC 4.2.1.22) from Lactiplantibacillus plantarum
PFams: PALP
303 amino acids: PaperBLAST, CDD

CYSK1_CAEEL / Q93244 Cysteine synthase 1; O-acetylserine (thiol)-lyase 1; OAS-TL; EC 2.5.1.47 from Caenorhabditis elegans
Q93244 cysteine synthase (EC 2.5.1.47) from Caenorhabditis elegans
PFams: PALP
341 amino acids: PaperBLAST, CDD, SwissProt::Q93244
40% identical to

F9UT54 cysteine synthase (EC 2.5.1.47); cystathionine beta-synthase (EC 4.2.1.22) from Lactiplantibacillus plantarum
PFams: PALP
303 amino acids: PaperBLAST, CDD

CYSD1_ARATH / Q9S6Z7 Bifunctional L-3-cyanoalanine synthase/cysteine synthase D1; Beta-substituted Ala synthase 4;1; ARAth-Bsas4;1; Cysteine synthase D1; AtcysD1; O-acetylserine (thiol)-lyase 3; EC 2.5.1.47; EC 4.4.1.9 from Arabidopsis thaliana (Mouse-ear cress)
PFams: PALP
324 amino acids: PaperBLAST, CDD, SwissProt::Q9S6Z7
40% identical to

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for CBS.)

Q9EYM7 cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Streptomyces venezuelae
PFams: PALP, CBS
463 amino acids: PaperBLAST, CDD, BRENDA::Q9EYM7
67% identical to

Y1077_MYCTU / P9WP51 Probable cystathionine beta-synthase Rv1077; Beta-thionase; Serine sulfhydrase; EC 4.2.1.22 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: PALP, CBS, CBS
464 amino acids: PaperBLAST, CDD