Other Characterized Proteins Similar to CGL

GapMind for Amino acid biosynthesis

Other Characterized Proteins Similar to CGL

Finding the characterized proteins for CGL (cystathionine gamma-lyase) in L-cysteine biosynthesis

Or see clustering for step CGL

Or see all steps for L-cysteine biosynthesis

Or cluster curated proteins matching a keyword

Definition of CGL

Curated proteins matching cystathionine gamma-lyase
Curated proteins matching cystathionine-gamma-lyase
Ignore hits to Q9M1R1 when looking for 'other' hits (cystathionine gamma-lyase (EC 4.4.1.1). L-cysteine desulfhydrase; AtL-CDes1; L-CDes1; AtLCD; EC 4.4.1.28)
Ignore hits to F4K5T2 when looking for 'other' hits (L-cysteine desulfidase (EC 4.4.1.28). Bifunctional cystathionine gamma-lyase/cysteine synthase; Beta-substituted Ala synthase 4;3; ARAth-Bsas4;3; L-cysteine desulfhydrase 1; DES1; O-acetylserine (thiol)-lyase; OASTL; Protein CS-LIKE; EC 2.5.1.47; EC 4.4.1.1)
Ignore hits to Q1M0P5 when looking for 'other' hits (Cystathionine gamma-synthase; CGS; O-succinylhomoserine (thiol)-lyase; EC 2.5.1.48. cystathionine gamma-synthase (EC 2.5.1.48))
Ignore hits to CH_088676 when looking for 'other' hits (cystathionine beta-lyase; EC 4.4.1.8)
Comment: EC 4.4.1.1 includes some other reactions, so it is not used to define CGL. Q9M1R1 is misannotated in BRENDA. SwissProt annotates the cysteine desulfurase DES1 (F4K5T2) with this activity, but we did not find evidence for it, so it is ignored. "MetB" from Helicobacter pylori was originally reported to be a cystathionine gamma-synthase (i.e., Q1M0P5 in BRENDA), but was later identified as a CGL (PMC2820867), so Q1M0P5 is ignored. Similarly, "MetC" from Lactoccus lactis (A2RM21) is reported to be a CGL and a cystathionine beta-lyase (PMID:10620674); another paper proposed that it is a CBL but did not distinguish between the two activities (PMC91783, cited by CharProtDB, which is ignored).

Fetched 17 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 36 other characterized sequences. (Found 53 hits including self hits.)

Removing ignored items reduces this to 34 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for CGL.)

METC_COXBU / Q83A83 Cystathionine beta-lyase; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13 from Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
PFams: Cys_Met_Meta_PP, Aminotran_1_2
387 amino acids: PaperBLAST, CDD, SwissProt::Q83A83
63% identical to

Q5H4T8 cystathionine gamma-lyase (EC 4.4.1.1) from Xanthomonas oryzae pv. oryzae
PFams: Cys_Met_Meta_PP
397 amino acids: PaperBLAST, CDD

METB_MYCTU / P9WGB7 Cystathionine gamma-synthase; CGS; O-succinylhomoserine (thiol)-lyase; EC 2.5.1.48 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, DegT_DnrJ_EryC1, Aminotran_1_2
388 amino acids: PaperBLAST, CDD, SwissProt::P9WGB7
56% identical to

Q5H4T8 cystathionine gamma-lyase (EC 4.4.1.1) from Xanthomonas oryzae pv. oryzae
PFams: Cys_Met_Meta_PP
397 amino acids: PaperBLAST, CDD

A0PKT3 cystathionine gamma-synthase (EC 2.5.1.48) from Mycobacterium ulcerans
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, DegT_DnrJ_EryC1, Aminotran_5
388 amino acids: PaperBLAST, CDD, BRENDA::A0PKT3
54% identical to

Q5H4T8 cystathionine gamma-lyase (EC 4.4.1.1) from Xanthomonas oryzae pv. oryzae
PFams: Cys_Met_Meta_PP
397 amino acids: PaperBLAST, CDD

METC_BACSU / O31632 Cystathionine beta-lyase MetC; CBL; Beta-cystathionase MetC; Cysteine lyase MetC; Cysteine-S-conjugate beta-lyase MetC; EC 4.4.1.13 from Bacillus subtilis (strain 168)
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Aminotran_5
390 amino acids: PaperBLAST, CDD, SwissProt::O31632
52% identical to

A2RM21 cystathionine gamma-lyase (EC 4.4.1.1); cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Lactococcus lactis
RF|YP_001033049.1 cystathionine beta-lyase; EC 4.4.1.8 from Lactococcus lactis subsp. cremoris MG1363
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1, Aminotran_5
380 amino acids: PaperBLAST, CDD

H7C6A2 cystathionine gamma-synthase (EC 2.5.1.48) from Corynebacterium glutamicum
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1
386 amino acids: PaperBLAST, CDD, BRENDA::H7C6A2
52% identical to

P31373 Cys3 (EC 4.4.1.1) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
CYS3_YEAST / P31373 Cystathionine gamma-lyase; gamma-CTLase; Gamma-cystathionase; Sulfur transfer protein 1; EC 4.4.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P31373 cystathionine gamma-lyase (EC 4.4.1.1) from Saccharomyces cerevisiae
PFams: Cys_Met_Meta_PP
394 amino acids: PaperBLAST, CDD

MEGL_FUSNP / Q8L0X4 L-methionine gamma-lyase; MGL; Homocysteine desulfhydrase; L-methionine-alpha-deamino-gamma-mercaptomethane-lyase; METase; EC 4.4.1.11; EC 4.4.1.2 from Fusobacterium nucleatum subsp. polymorphum (Fusobacterium polymorphum)
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, Aminotran_1_2, Aminotran_5
395 amino acids: PaperBLAST, CDD, SwissProt::Q8L0X4
50% identical to

P56069 cystathionine gamma-lyase (EC 4.4.1.1) from Helicobacter pylori (strain ATCC 700392 / 26695)
PFams: Cys_Met_Meta_PP, Aminotran_1_2
380 amino acids: PaperBLAST, CDD

MEGL_FUSNN / Q8RDT4 L-methionine gamma-lyase; MGL; Homocysteine desulfhydrase; L-cysteine desulfidase; EC 4.4.1.11; EC 4.4.1.2; EC 4.4.1.28 from Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355)
Q8RDT4 methionine gamma-lyase (EC 4.4.1.11) from Fusobacterium nucleatum subsp. nucleatum
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, Aminotran_1_2, Aminotran_5
395 amino acids: PaperBLAST, CDD, BRENDA::Q8RDT4
50% identical to

P56069 cystathionine gamma-lyase (EC 4.4.1.1) from Helicobacter pylori (strain ATCC 700392 / 26695)
PFams: Cys_Met_Meta_PP, Aminotran_1_2
380 amino acids: PaperBLAST, CDD

METI_BACSU / O31631 Cystathionine gamma-synthase/O-acetylhomoserine (thiol)-lyase; CGS/OAH thiolyase; O-acetylhomoserine sulfhydrylase; OAH sulfhydrylase; EC 2.5.1.- from Bacillus subtilis (strain 168)
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1, Aminotran_1_2
373 amino acids: PaperBLAST, CDD, SwissProt::O31631
49% identical to

MCCB_BACSU / O05394 Cystathionine gamma-lyase; Gamma-cystathionase; Homocysteine gamma-lyase; EC 4.4.1.1; EC 4.4.1.2 from Bacillus subtilis (strain 168)
O05394 cystathionine beta-synthase (O-acetyl-L-serine) (EC 2.5.1.134) from Bacillus subtilis
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1, Aminotran_1_2, Aminotran_5
379 amino acids: PaperBLAST, CDD

A0A1L7H888 methionine gamma-lyase (EC 4.4.1.11) from Clostridium tetani
PFams: Cys_Met_Meta_PP, Beta_elim_lyase, DegT_DnrJ_EryC1, Aminotran_1_2, Met_gamma_lyase, Aminotran_5
398 amino acids: PaperBLAST, CDD, BRENDA::A0A1L7H888
48% identical to

J7TA22 methionine gamma-lyase (EC 4.4.1.11) from Clostridium sporogenes
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, Aminotran_1_2, Aminotran_5
400 amino acids: PaperBLAST, CDD, BRENDA::J7TA22
47% identical to

P56069 cystathionine gamma-lyase (EC 4.4.1.1) from Helicobacter pylori (strain ATCC 700392 / 26695)
PFams: Cys_Met_Meta_PP, Aminotran_1_2
380 amino acids: PaperBLAST, CDD

O15565 methionine gamma-lyase (EC 4.4.1.11) from Trichomonas vaginalis
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, Aminotran_1_2, Aminotran_5
398 amino acids: PaperBLAST, CDD, BRENDA::O15565
46% identical to

Q84AR1 methionine gamma-lyase (EC 4.4.1.11); alliin lyase (EC 4.4.1.4) from Citrobacter freundii
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, Aminotran_1_2, Beta_elim_lyase, Aminotran_5
398 amino acids: PaperBLAST, CDD, BRENDA::Q84AR1
48% identical to

Q5H4T8 cystathionine gamma-lyase (EC 4.4.1.1) from Xanthomonas oryzae pv. oryzae
PFams: Cys_Met_Meta_PP
397 amino acids: PaperBLAST, CDD

A0A0J6G7P5 methionine γ-lyase (EC 4.4.1.11) from Pseudomonas deceptionensis
MEGL_PSEDM / A0A0J6G7P5 L-methionine gamma-lyase; MGL; EC 4.4.1.11 from Pseudomonas deceptionensis
PFams: Cys_Met_Meta_PP, Met_gamma_lyase
399 amino acids: PaperBLAST, CDD, SwissProt::A0A0J6G7P5
45% identical to

P13254 MdeA from Pseudomonas putida
MEGL_PSEPU / P13254 L-methionine gamma-lyase; MGL; Homocysteine desulfhydrase; L-methioninase; EC 4.4.1.11; EC 4.4.1.2 from Pseudomonas putida (Arthrobacter siderocapsulatus)
PFams: Cys_Met_Meta_PP, Beta_elim_lyase, Met_gamma_lyase, Aminotran_1_2, Aminotran_5
398 amino acids: PaperBLAST, CDD, SwissProt::P13254
46% identical to

Q5H4T8 cystathionine gamma-lyase (EC 4.4.1.1) from Xanthomonas oryzae pv. oryzae
PFams: Cys_Met_Meta_PP
397 amino acids: PaperBLAST, CDD

O15564 methionine gamma-lyase (EC 4.4.1.11) from Trichomonas vaginalis
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, Aminotran_1_2, Aminotran_5
396 amino acids: PaperBLAST, CDD, BRENDA::O15564
45% identical to

METC_STAHJ / Q4L332 Cystathionine beta-lyase MetC; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13 from Staphylococcus haemolyticus (strain JCSC1435)
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1, Aminotran_5
391 amino acids: PaperBLAST, CDD, SwissProt::Q4L332
45% identical to

SO1812 Methionine gamma-lyase (EC 4.4.1.11) from Shewanella oneidensis MR-1
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1, Aminotran_1_2
397 amino acids: PaperBLAST, CDD, reanno::MR1:200974
45% identical to

MEGL_PORGI / Q7MX71 L-methionine gamma-lyase; MGL; Homocysteine desulfhydrase; L-methionine-alpha-deamino-gamma-mercaptomethane-lyase; METase; EC 4.4.1.11; EC 4.4.1.2 from Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Q7MX71 methionine gamma-lyase (EC 4.4.1.11) from Porphyromonas gingivalis
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, Aminotran_1_2, Aminotran_5
399 amino acids: PaperBLAST, CDD, BRENDA::Q7MX71
44% identical to

C3VMV9 methionine gamma-lyase (EC 4.4.1.11) from Porphyromonas gingivalis
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, Aminotran_1_2, Aminotran_5
393 amino acids: PaperBLAST, CDD, BRENDA::C3VMV9
45% identical to

b3939 O-succinylhomoserine(thiol)-lyase / O-succinylhomoserine lyase (EC 2.5.1.48) from Escherichia coli K-12 substr. MG1655
P00935 O-succinylhomoserine(thiol)-lyase / O-succinylhomoserine lyase (EC 2.5.1.48) from Escherichia coli (strain K12)
METB_ECOLI / P00935 Cystathionine gamma-synthase; CGS; O-succinylhomoserine (thiol)-lyase; EC 2.5.1.48 from Escherichia coli (strain K12)
PFams: Cys_Met_Meta_PP, Aminotran_1_2
386 amino acids: PaperBLAST, CDD, SwissProt::P00935
45% identical to

Q5MQ31 methionine gamma-lyase (EC 4.4.1.11) from Brevibacterium linens
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1, Aminotran_1_2, Aminotran_5
425 amino acids: PaperBLAST, CDD, BRENDA::Q5MQ31
46% identical to

Q5H4T8 cystathionine gamma-lyase (EC 4.4.1.1) from Xanthomonas oryzae pv. oryzae
PFams: Cys_Met_Meta_PP
397 amino acids: PaperBLAST, CDD

A0A0M3VI47 cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Mimosa pudica
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Aminotran_5
457 amino acids: PaperBLAST, CDD, BRENDA::A0A0M3VI47
46% identical to

MEGL_TREDE / Q73KL7 L-methionine gamma-lyase; MGL; Homocysteine desulfhydrase; L-methionine-alpha-deamino-gamma-mercaptomethane-lyase; METase; EC 4.4.1.11; EC 4.4.1.2 from Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)
Q73KL7 methionine gamma-lyase (EC 4.4.1.11) from Treponema denticola
PFams: Cys_Met_Meta_PP, Met_gamma_lyase
401 amino acids: PaperBLAST, CDD, BRENDA::Q73KL7
44% identical to

P56069 cystathionine gamma-lyase (EC 4.4.1.1) from Helicobacter pylori (strain ATCC 700392 / 26695)
PFams: Cys_Met_Meta_PP, Aminotran_1_2
380 amino acids: PaperBLAST, CDD

CBL_NEUCR / Q1K8G0 Cystathionine beta-lyase; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13 from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q1K8G0 cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Neurospora crassa
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1, Aminotran_5
457 amino acids: PaperBLAST, CDD, BRENDA::Q1K8G0
44% identical to

CGL_DICDI / Q55DV9 Cystathionine gamma-lyase; CGL; CSE; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase; EC 4.4.1.1; EC 4.4.1.2 from Dictyostelium discoideum (Social amoeba)
PFams: Cys_Met_Meta_PP, Aminotran_1_2
387 amino acids: PaperBLAST, CDD

P53780 cystathionine β-lyase monomer (EC 4.4.1.13) from Arabidopsis thaliana
METC_ARATH / P53780 Cystathionine beta-lyase, chloroplastic; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Aminotran_5
464 amino acids: PaperBLAST, CDD, SwissProt::P53780
46% identical to

Q8KNG3 methionine gamma-lyase (EC 4.4.1.11) from Micromonospora echinospora
PFams: Cys_Met_Meta_PP, Aminotran_1_2
381 amino acids: PaperBLAST, CDD, BRENDA::Q8KNG3
45% identical to

Q5H4T8 cystathionine gamma-lyase (EC 4.4.1.1) from Xanthomonas oryzae pv. oryzae
PFams: Cys_Met_Meta_PP
397 amino acids: PaperBLAST, CDD

P55218 O-succinyl-L-homoserine sulfhydrylase (EC 2.5.1.48) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
METZ_PSEAE / P55218 O-succinylhomoserine sulfhydrylase; OSH sulfhydrylase; OSHS sulfhydrylase; EC 2.5.1.- from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Aminotran_5, DegT_DnrJ_EryC1
403 amino acids: PaperBLAST, CDD, SwissProt::P55218
43% identical to

Q5H4T8 cystathionine gamma-lyase (EC 4.4.1.1) from Xanthomonas oryzae pv. oryzae
PFams: Cys_Met_Meta_PP
397 amino acids: PaperBLAST, CDD

Q86D27 methionine gamma-lyase (EC 4.4.1.11) from Entamoeba histolytica
PFams: Cys_Met_Meta_PP, Aminotran_1_2
392 amino acids: PaperBLAST, CDD, BRENDA::Q86D27
41% identical to

CH_122245 cystathionine beta-lyase; EC 4.4.1.8 from Emericella nidulans
PFams: Cys_Met_Meta_PP, Aminotran_1_2
439 amino acids: PaperBLAST, CDD, CharProtDB::CH_122245
42% identical to

P55217 cystathionine γ-synthase (EC 2.5.1.48) from Arabidopsis thaliana
CGS1_ARATH / P55217 Cystathionine gamma-synthase 1, chloroplastic; AtCGS1; METHIONINE OVERACCUMULATION 1; O-succinylhomoserine (thiol)-lyase; EC 2.5.1.48 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Cys_Met_Meta_PP
563 amino acids: PaperBLAST, CDD, SwissProt::P55217
41% identical to

Q86D28 methionine gamma-lyase (EC 4.4.1.11) from Entamoeba histolytica
PFams: Cys_Met_Meta_PP, Aminotran_1_2
389 amino acids: PaperBLAST, CDD, BRENDA::Q86D28
41% identical to

U6BYK3 mimosinase (EC 4.3.3.8) from Mimosa pudica
U6BYK3 mimosinase (EC 3.5.1.61) from Mimosa pudica
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Aminotran_5
442 amino acids: PaperBLAST, CDD, metacyc::MONOMER-124312
41% identical to

L0EKR2 cystathionine gamma-synthase (EC 2.5.1.48) from Lens culinaris
PFams: Cys_Met_Meta_PP, Aminotran_1_2
535 amino acids: PaperBLAST, CDD, BRENDA::L0EKR2
40% identical to

A8CEI3 mimosinase (EC 3.5.1.61) from Leucaena leucocephala
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, Aminotran_5, Aminotran_1_2
443 amino acids: PaperBLAST, CDD, BRENDA::A8CEI3
42% identical to

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for CGL.)

METB_HELPX / Q1M0P5 Cystathionine gamma-synthase; CGS; O-succinylhomoserine (thiol)-lyase; EC 2.5.1.48 from Helicobacter pylori (Campylobacter pylori)
Q1M0P5 cystathionine gamma-synthase (EC 2.5.1.48) from Helicobacter pylori
PFams: Cys_Met_Meta_PP, Aminotran_1_2
380 amino acids: PaperBLAST, CDD, SwissProt::Q1M0P5
97% identical to

P56069 cystathionine gamma-lyase (EC 4.4.1.1) from Helicobacter pylori (strain ATCC 700392 / 26695)
PFams: Cys_Met_Meta_PP, Aminotran_1_2
380 amino acids: PaperBLAST, CDD

GB|AAF14695.1 cystathionine beta-lyase; EC 4.4.1.8 from Austrochilidae
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Aminotran_5
380 amino acids: PaperBLAST, CDD, CharProtDB::CH_088676
94% identical to