Other Characterized Proteins Similar to serA

Finding the characterized proteins for serA (3-phosphoglycerate dehydrogenase) in L-cysteine biosynthesis

Or see clustering for step serA

Or see all steps for L-cysteine biosynthesis

Or cluster curated proteins matching a keyword

Definition of serA

• Curated proteins or TIGRFams with EC 1.1.1.95
• UniProt sequence A0A1X9ZCD3: SubName: Full=3-phosphoglycerate dehydrogenase {ECO:0000313|EMBL:ARS42937.1};
• UniProt sequence Q6LWW6: RecName: Full=D-3-phosphoglycerate dehydrogenase {ECO:0000256|RuleBase:RU363003}; EC=1.1.1.95 {ECO:0000256|RuleBase:RU363003};
• Ignore hits to Q4JDI4 when looking for 'other' hits (phosphoglycerate kinase (EC 2.7.2.3))
• Ignore hits to HP_RS05420-MONOMER when looking for 'other' hits (cinnamyl-alcohol dehydrogenase (EC 1.1.1.2; EC 1.1.1.95; EC 1.1.1.195))
• Ignore hits to SGL_RS08600-MONOMER when looking for 'other' hits (glycerate dehydrogenase (EC 1.1.1.29))
• Predicted: UniProt sequence A0A374I5P9: RecName: Full=D-3-phosphoglycerate dehydrogenase {ECO:0000256|ARBA:ARBA00021582}; EC=1.1.1.399 {ECO:0000256|ARBA:ARBA00013001}; EC=1.1.1.95 {ECO:0000256|ARBA:ARBA00013143}; AltName: Full=2-oxoglutarate reductase {ECO:0000256|ARBA:ARBA00030455};
• UniProt sequence Q5JGC4: SubName: Full=D-3-phosphoglycerate dehydrogenase {ECO:0000313|EMBL:BAD86155.1};
• Comment: BRENDA::Q4JDI4 is misannotated as 3-phosphoglycerate dehydrogenase instead of 3-phosphoglycerate kinase. (The curators were notified and report that they have corrected this.) CA265_RS09010 (A0A1X9ZCD3) from Pedobacter sp. GW460-11-11-14-LB5 is annotated as 3-phosphoglycerate dehydrogenase and has auxotrophic phenotypes. In particular, mutants are partially rescued by glycine or serine. Also it is adjacent to the putative serC. MMP1588 (Q6LWW6) was identified as the serA of Methanococcus (PMC1797378). Ignore link_RS05420-MONOMER which has this EC but has a different function. Ignore similarity to sll1908 (link_RS08600-MONOMER) which seems likely to be serA but was proposed (without experimental evidence) to be hydroxpyruvate reductase. In Roseburia faecis, the putative serA (A0A374I5P9) is diverged but is similar to the serA part of Echvi_2777 and is conserved next to serC and DUF1015 (putative serB). In Thermococcus kodakarensis, TK1966 (Q5JGC4) is the 3-phosphoglycerate dehydrogenase (PMC5120207).

Fetched 31 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 7 other characterized sequences. (Found 34 hits including self hits.)

Removing ignored items reduces this to 6 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for serA.)

HPR_THEMA / Q9X1C1 Hydroxypyruvate reductase; HPR; EC 1.1.1.81 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2
306 amino acids: PaperBLAST, CDD, SwissProt::Q9X1C1
50% identical to

Q5JGC4 D-3-phosphoglycerate dehydrogenase
304 amino acids: PaperBLAST, CDD

GYAR_THELN / Q9C4M5 Glyoxylate reductase; EC 1.1.1.26 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)
Q9C4M5 glyoxylate reductase (EC 1.1.1.26) from Thermococcus litoralis
PFams: 2-Hacid_dh, 2-Hacid_dh_C, IlvN, NAD_binding_2
331 amino acids: PaperBLAST, CDD, SwissProt::Q9C4M5
47% identical to

Q5JGC4 D-3-phosphoglycerate dehydrogenase
304 amino acids: PaperBLAST, CDD

F8AEA4 glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Pyrococcus yayanosii
PFams: 2-Hacid_dh, 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2
333 amino acids: PaperBLAST, CDD, BRENDA::F8AEA4
47% identical to

Q5JGC4 D-3-phosphoglycerate dehydrogenase
304 amino acids: PaperBLAST, CDD

Q8U3Y2 glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Pyrococcus furiosus
PFams: 2-Hacid_dh, 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2
336 amino acids: PaperBLAST, CDD, BRENDA::Q8U3Y2
46% identical to

Q5JGC4 D-3-phosphoglycerate dehydrogenase
304 amino acids: PaperBLAST, CDD

BPHYT_RS11290 2-ketogluconate 6-phosphate reductase (EC 1.1.1.43) from Burkholderia phytofirmans PsJN
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2
321 amino acids: PaperBLAST, CDD, reanno::BFirm:BPHYT_RS11290
41% identical to

Q5JGC4 D-3-phosphoglycerate dehydrogenase
304 amino acids: PaperBLAST, CDD

HADHA_ASPOR / Q2UH56 2-hydroxyacid dehydrogenase A; 2-HadhA; EC 1.1.1.272 from Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
PFams: 2-Hacid_dh, 2-Hacid_dh_C
347 amino acids: PaperBLAST, CDD, SwissProt::Q2UH56
41% identical to

Q5JGC4 D-3-phosphoglycerate dehydrogenase
304 amino acids: PaperBLAST, CDD

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for serA.)

P73821 glycerate dehydrogenase (EC 1.1.1.29) from Synechocystis sp. (strain PCC 6803 / Kazusa)
PFams: 2-Hacid_dh, 2-Hacid_dh_C, PGDH_inter, ACT
554 amino acids: PaperBLAST, CDD, metacyc::SGL_RS08600-MONOMER
46% identical to

Q5JGC4 D-3-phosphoglycerate dehydrogenase
304 amino acids: PaperBLAST, CDD