Other Characterized Proteins Similar to gltX

Finding the characterized proteins for gltX (glutamyl-tRNA(Glx) synthetase) in L-glutamine biosynthesis

Or see clustering for step gltX

Or see all steps for L-glutamine biosynthesis

Or cluster curated proteins matching a keyword

Definition of gltX

• Curated proteins or TIGRFams with EC 6.1.1.24
• UniProt sequence A0A0H3C8P5_CAUVN: RecName: Full=Glutamate--tRNA ligase {ECO:0000256|HAMAP-Rule:MF_00022}; EC=6.1.1.17 {ECO:0000256|HAMAP-Rule:MF_00022}; AltName: Full=Glutamyl-tRNA synthetase {ECO:0000256|HAMAP-Rule:MF_00022}; Short=GluRS {ECO:0000256|HAMAP-Rule:MF_00022};
• Ignore hits to P00962 when looking for 'other' hits (glutamine-tRNA ligase (EC 6.1.1.18); glutamate-tRNAGln ligase (EC 6.1.1.24). glutaminyl-tRNA synthetase; EC 6.1.1.18. Glutamine--tRNA ligase; Glutaminyl-tRNA synthetase; GlnRS; EC 6.1.1.18. glutamine—tRNA ligase (EC 6.1.1.18). glutamine—tRNA ligase (EC 6.1.1.18))
• Curated sequence Q8DLI5: Glutamate--tRNA ligase; Glutamyl-tRNA synthetase; GluRS; EC 6.1.1.17
• Comment: Glutamyl-tRNA(Glu/Gln) is usually formed by a nondescriminating glutamyl-tRNA synthetase. CCNA_01982 (A0A0H3C8P5_CAUVN) from Caulobacter crescentus is the sole glutamyl-tRNA synthetase, there is no glutaminyl-tRNA synthetase, and gatABC are present, so we annotated it as non-discriminating. In contrast, as of March 2019, unirule UR000075658 labeled it as EC 6.1.1.17 (the discriminating kind). E. coli glutamine-tRNA ligase (P00962) is misannotated in BRENDA as the non-discriminating ligase. Q8DLI5 is a non-discriminating glutamyl-tRNA synthetase (PMID:16876193) but is not given this EC number in SwissProt.

Fetched 6 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 3 other characterized sequences. (Found 8 hits including self hits.)

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for gltX.)

SYEM_ARATH / Q9FEA2 Glutamate--tRNA ligase, chloroplastic/mitochondrial; AtERS; Glutamyl-tRNA synthetase; GluRS; Protein OVULE ABORTION 3; EC 6.1.1.17 from Arabidopsis thaliana (Mouse-ear cress)
PFams: tRNA-synt_1c, Anticodon_2
570 amino acids: PaperBLAST, CDD, SwissProt::Q9FEA2
41% identical to

P22250 glutamyl-tRNA^Glx synthetase (EC 6.1.1.17; EC 6.1.1.24) from Bacillus subtilis (strain 168)
PFams: tRNA-synt_1c, Anticodon_2
483 amino acids: PaperBLAST, CDD

b2400 glutamate—tRNA ligase (EC 6.1.1.17) from Escherichia coli K-12 substr. MG1655
P04805 glutamate—tRNA ligase (EC 6.1.1.17) from Escherichia coli (strain K12)
SYE_ECOLI / P04805 Glutamate--tRNA ligase; Glutamyl-tRNA synthetase; GluRS; EC 6.1.1.17 from Escherichia coli (strain K12)
GB|AAC75457.1 glutamyl-tRNA synthetase; EC 6.1.1.17 from Escherichia coli K12
PFams: tRNA-synt_1c, Anticodon_2
471 amino acids: PaperBLAST, CDD, CharProtDB::CH_003252
42% identical to

SYE_THEVB / Q8DLI5 Glutamate--tRNA ligase; Glutamyl-tRNA synthetase; GluRS; EC 6.1.1.17 from Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1)
PFams: tRNA-synt_1c, Anticodon_2
485 amino acids: PaperBLAST, CDD

SYE_THET8 / P27000 Glutamate--tRNA ligase; Glutamyl-tRNA synthetase; GluRS; EC 6.1.1.17 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
PFams: tRNA-synt_1c, Anticodon_2
468 amino acids: PaperBLAST, CDD, SwissProt::P27000
41% identical to

Q9X2I8 glutamate-tRNAGln ligase (EC 6.1.1.24) from Thermotoga maritima
PFams: tRNA-synt_1c, tRNA-synt_1c, Anticodon_2
487 amino acids: PaperBLAST, CDD