Clusters of Characterized Proteins

Clustering the characterized proteins for glyXL (putative glycine synthesis enzyme, catalytic component) in glycine biosynthesis

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Definition of glyXL

• UniProt sequence Q8G510: RecName: Full=UPF0210 protein BL1209 {ECO:0000255|HAMAP-Rule:MF_01221};
• UniProt sequence Q6LXC5: RecName: Full=UPF0210 protein MMP1427 {ECO:0000255|HAMAP-Rule:MF_01221};
• UniProt sequence Q8DRD2: RecName: Full=UPF0210 protein spr0218 {ECO:0000255|HAMAP-Rule:MF_01221};
• Comment: Glycine synthesis by Bifidobacterium breve or Methanococcus maripaludis requires two genes: a putative enzyme (distantly related to anaerobic ribonucleotide reductase), which we call glyXL, and an ACT domain protein, which we call glyXS (BBR_RS12920 and BBR_RS12915 or MMP_RS07345 and MMP_RS03450, Anthony Shiver and Leslie Day). These proteins are usually encoded next to each other (although not in Methanococcus). A homolog of glyXL from Streptococcus (spr0218, Q8DRD2) is also required for glycine synthesis (PMC2739083). And a similar operon is regulated by glycine riboswitches (see BMMGA3_03000, discussed in PMC4342826).

Fetched 3 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 3 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 445-458 amino acids (not heteromeric)

Q6LXC5 UPF0210 protein MMP1427 {ECO:0000255|HAMAP-Rule:MF_01221}
458 amino acids: PaperBLAST, CDD, Compare to cluster

Q8DRD2 UPF0210 protein spr0218 {ECO:0000255|HAMAP-Rule:MF_01221}
445 amino acids: PaperBLAST, CDD, Compare to cluster

Q8G510 UPF0210 protein BL1209 {ECO:0000255|HAMAP-Rule:MF_01221}
454 amino acids: PaperBLAST, CDD, Compare to cluster