GapMind for Amino acid biosynthesis

 

Clusters of Characterized Proteins

Clustering the characterized proteins for hisB (imidazoleglycerol-phosphate dehydratase) in L-histidine biosynthesis

Or see other characterized proteins similar to hisB

Or see all steps for L-histidine biosynthesis

Or cluster curated proteins matching a keyword

Definition of hisB

Fetched 16 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 16 of these sequences

Found 2 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 195-272 amino acids (not heteromeric)

H9C4A4 imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) from Kazachstania humilis
PFams: IGPD
226 amino acids: PaperBLAST, CDD, Compare to cluster

HIS5B_ARATH / O23346 Imidazoleglycerol-phosphate dehydratase 2, chloroplastic; IGPD 2; Protein HISTIDINE BIOSYNTHESIS 5B; EC 4.2.1.19 from Arabidopsis thaliana (Mouse-ear cress)
O23346 imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) from Arabidopsis thaliana
PFams: IGPD
272 amino acids: PaperBLAST, CDD, Compare to cluster

CH_122405 imidazoleglycerol-phosphate dehydratase; EC 4.2.1.19 from Emericella nidulans
PFams: IGPD
247 amino acids: PaperBLAST, CDD, Compare to cluster

CH_123056 imidazoleglycerol-phosphate dehydratase; EC 4.2.1.19 from Candida albicans
PFams: IGPD
222 amino acids: PaperBLAST, CDD, Compare to cluster

GI|3116116 imidazoleglycerol-phosphate dehydratase His5; EC 4.2.1.19 from Schizosaccharomyces pombe
PFams: IGPD
216 amino acids: PaperBLAST, CDD, Compare to cluster

HIS7_YEAST / P06633 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: IGPD
220 amino acids: PaperBLAST, CDD, Compare to cluster

HIS7_CRYNJ / P0CO22 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
PFams: IGPD
202 amino acids: PaperBLAST, CDD, Compare to cluster

P34047 imidazoleglycerolphosphate dehydratase (EC 4.2.1.19) from Arabidopsis thaliana
HIS5A_ARATH / P34047 Imidazoleglycerol-phosphate dehydratase 1, chloroplastic; IGPD 1; Protein HISTIDINE BIOSYNTHESIS 5A; EC 4.2.1.19 from Arabidopsis thaliana (Mouse-ear cress)
PFams: IGPD
270 amino acids: PaperBLAST, CDD, Compare to cluster

HIS7_MYCTU / P9WML9 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: IGPD
210 amino acids: PaperBLAST, CDD, Compare to cluster

B2SZ63 Imidazoleglycerol-phosphate dehydratase {ECO:0000255|HAMAP-Rule:MF_00076}; Short=IGPD {ECO:0000255|HAMAP-Rule:MF_00076}; EC=4.2.1.19 {ECO:0000255|HAMAP-Rule:MF_00076}
195 amino acids: PaperBLAST, CDD, Compare to cluster

Q9HU41 Imidazoleglycerol-phosphate dehydratase {ECO:0000255|HAMAP-Rule:MF_00076}; Short=IGPD {ECO:0000255|HAMAP-Rule:MF_00076}; EC=4.2.1.19 {ECO:0000255|HAMAP-Rule:MF_00076}
197 amino acids: PaperBLAST, CDD, Compare to cluster

BPHYT_RS17700 imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) from Burkholderia phytofirmans PsJN
PFams: IGPD
195 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 355-382 amino acids (not heteromeric)

HIS7_SPILD / D2QPE6 Histidine biosynthesis bifunctional protein HisB; EC 3.1.3.15; EC 4.2.1.19 from Spirosoma linguale (strain ATCC 33905 / DSM 74 / LMG 10896 / Claus 1)
PFams: PNK3P, Hydrolase_like, IGPD
382 amino acids: PaperBLAST, CDD, Compare to cluster

HIS7_BACTN / Q8ABA7 Histidine biosynthesis bifunctional protein HisB; EC 3.1.3.15; EC 4.2.1.19 from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)
PFams: Hydrolase_like, IGPD
374 amino acids: PaperBLAST, CDD, Compare to cluster

HIS7_ECO57 / Q9S5G5 Histidine biosynthesis bifunctional protein HisB; EC 3.1.3.15; EC 4.2.1.19 from Escherichia coli O157:H7
PFams: PNK3P, Hydrolase_like, IGPD
355 amino acids: PaperBLAST, CDD, Compare to cluster

b2022 imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (EC 4.2.1.19; EC 3.1.3.15) from Escherichia coli K-12 substr. MG1655
P06987 imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (EC 4.2.1.19; EC 3.1.3.15) from Escherichia coli (strain K12)
PFams: PNK3P, Hydrolase_like, IGPD
355 amino acids: PaperBLAST, CDD, Compare to cluster