Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for hisB (IGP dehydratase) in L-histidine biosynthesis

Or see other characterized proteins similar to hisB

Or see all steps for L-histidine biosynthesis

Or cluster curated proteins matching a keyword

Definition of hisB

Curated proteins or TIGRFams with EC 4.2.1.19
UniProt sequence B2SZ63: RecName: Full=Imidazoleglycerol-phosphate dehydratase {ECO:0000255|HAMAP-Rule:MF_00076}; Short=IGPD {ECO:0000255|HAMAP-Rule:MF_00076}; EC=4.2.1.19 {ECO:0000255|HAMAP-Rule:MF_00076};
UniProt sequence Q9HU41: RecName: Full=Imidazoleglycerol-phosphate dehydratase {ECO:0000255|HAMAP-Rule:MF_00076}; Short=IGPD {ECO:0000255|HAMAP-Rule:MF_00076}; EC=4.2.1.19 {ECO:0000255|HAMAP-Rule:MF_00076};
Comment: Fitness data showed that BPHYT_RS17700 (B2SZ63) from Burkholderia phytofirmans is required for histidine biosynthesis. PA5143 (Q9HU41) from Pseudomonas aeruginosa is required for histidine biosynthesis (PMC7028973). as

Fetched 15 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 15 of these sequences

Found 2 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 195-272 amino acids (not heteromeric)

H9C4A4 imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
PFams: IGPD
226 amino acids: PaperBLAST, CDD, Compare to cluster

CH_122405 imidazoleglycerol-phosphate dehydratase; EC 4.2.1.19
PFams: IGPD
247 amino acids: PaperBLAST, CDD, Compare to cluster

CH_123056 imidazoleglycerol-phosphate dehydratase; EC 4.2.1.19
PFams: IGPD
222 amino acids: PaperBLAST, CDD, Compare to cluster

CH_125293 imidazoleglycerol-phosphate dehydratase His5; EC 4.2.1.19
PFams: IGPD
216 amino acids: PaperBLAST, CDD, Compare to cluster

O23346 Imidazoleglycerol-phosphate dehydratase 2, chloroplastic; IGPD 2; Protein HISTIDINE BIOSYNTHESIS 5B; EC 4.2.1.19
PFams: IGPD
272 amino acids: PaperBLAST, CDD, Compare to cluster

P06633 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19
PFams: IGPD
220 amino acids: PaperBLAST, CDD, Compare to cluster

P0CO22 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19
PFams: IGPD
202 amino acids: PaperBLAST, CDD, Compare to cluster

P34047 Imidazoleglycerol-phosphate dehydratase 1, chloroplastic; IGPD 1; Protein HISTIDINE BIOSYNTHESIS 5A; EC 4.2.1.19
AT3G22425-MONOMER imidazoleglycerolphosphate dehydratase (EC 4.2.1.19)
PFams: IGPD
270 amino acids: PaperBLAST, CDD, Compare to cluster

P9WML9 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19
PFams: IGPD
210 amino acids: PaperBLAST, CDD, Compare to cluster

B2SZ63 Imidazoleglycerol-phosphate dehydratase {ECO:0000255|HAMAP-Rule:MF_00076}; Short=IGPD {ECO:0000255|HAMAP-Rule:MF_00076}; EC=4.2.1.19 {ECO:0000255|HAMAP-Rule:MF_00076}
195 amino acids: PaperBLAST, CDD, Compare to cluster

Q9HU41 Imidazoleglycerol-phosphate dehydratase {ECO:0000255|HAMAP-Rule:MF_00076}; Short=IGPD {ECO:0000255|HAMAP-Rule:MF_00076}; EC=4.2.1.19 {ECO:0000255|HAMAP-Rule:MF_00076}
197 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 355-382 amino acids (not heteromeric)

D2QPE6 Histidine biosynthesis bifunctional protein HisB; EC 3.1.3.15; EC 4.2.1.19
PFams: PNK3P, Hydrolase_like, IGPD
382 amino acids: PaperBLAST, CDD, Compare to cluster

Q8ABA7 Histidine biosynthesis bifunctional protein HisB; EC 3.1.3.15; EC 4.2.1.19
PFams: Hydrolase_like, IGPD
374 amino acids: PaperBLAST, CDD, Compare to cluster

Q9S5G5 Histidine biosynthesis bifunctional protein HisB; EC 3.1.3.15; EC 4.2.1.19
PFams: PNK3P, Hydrolase_like, IGPD
355 amino acids: PaperBLAST, CDD, Compare to cluster

IMIDPHOSPHADEHYDHISTIDPHOSPHA-MONOMER imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (EC 4.2.1.19; EC 3.1.3.15)
PFams: PNK3P, Hydrolase_like, IGPD
355 amino acids: PaperBLAST, CDD, Compare to cluster