Clusters of Characterized Proteins

Clustering the characterized proteins for hisC (histidinol-phosphate aminotransferase) in L-histidine biosynthesis

Or see other characterized proteins similar to hisC

Or see all steps for L-histidine biosynthesis

Or cluster curated proteins matching a keyword

Definition of hisC

• Curated proteins or TIGRFams with EC 2.6.1.9
• UniProt sequence HIS8_BACSU: RecName: Full=Histidinol-phosphate aminotransferase; EC=2.6.1.9; AltName: Full=Imidazole acetol-phosphate transaminase;
• UniProt sequence A0A2R7PAQ8: RecName: Full=Histidinol-phosphate aminotransferase {ECO:0000256|HAMAP-Rule:MF_01023}; EC=2.6.1.9 {ECO:0000256|HAMAP-Rule:MF_01023}; AltName: Full=Imidazole acetol-phosphate transaminase {ECO:0000256|HAMAP-Rule:MF_01023};
• UniProt sequence A0A975E8Y9: RecName: Full=Histidinol-phosphate aminotransferase {ECO:0000256|HAMAP-Rule:MF_01023}; EC=2.6.1.9 {ECO:0000256|HAMAP-Rule:MF_01023}; AltName: Full=Imidazole acetol-phosphate transaminase {ECO:0000256|HAMAP-Rule:MF_01023};
• Ignore hits to BPHYT_RS14905 when looking for 'other' hits (Aromatic-amino-acid transaminase (EC 2.6.1.57))
• Comment: In Bacillus subtilis, the histidinol-phosphate aminotransferase activity is provided by a gene that is in a cluster of genes for tyrosine and phenylalanine biosynthesis (PMID:4431). Homology suggests that this activity is provided by "HisH" (BSU22620), which indeed is just upstream of tyrA (PMID:6092865). This protein is now usually referred to as "HisC" (HIS8_BACSU). GAMENC_05715 from Acidovorax sp. FHTAMBA (nearly identical to A0A2R7PAQ8) can complement a hisC- strain of E. coli (Bradley Biggs) and is in a histidine synthesis gene cluster. GW822FHT02A01_217 from Rhodoferax sp. GW822-FHT02A01 (similar to A0A975E8Y9) can complement a hisC- strain of E. coli (Bradley Biggs) and is in a histidine synthesis gene cluster. Fitness data for BPHYT_RS14905 from Burkholderia phytofirmans suggests that it is an aromatic amino acid transaminase, but it is 55% identical to TK06_RS12685, which can complement a hisC- mutant of E.coli (Bradley Biggs), so any similarity to it is ignored.

Fetched 23 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 23 of these sequences

Found 2 clusters of similar sequences. Download as table or as draft rules or view by cluster

Arabidopsis thaliana

HIS6A_ARATH / B9DHD3 Histidinol-phosphate aminotransferase 1, chloroplastic; Gene duplicate 1-B protein; Imidazole acetol-phosphate transaminase; Protein EMBRYO DEFECTIVE 2196; Protein HISTIDINE BIOSYNTHESIS 6A; EC 2.6.1.9 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Aminotran_1_2
417 amino acids: PaperBLAST, CDD (Cluster 1)

Azospirillum brasilense

AZOBR_RS20485 histidinol-phosphate aminotransferase [EC:2.6.1.9] from Azospirillum brasilense Sp245
PFams: Aminotran_1_2, Aminotran_5
364 amino acids: PaperBLAST, CDD (Cluster 1)

Bacillus subtilis

P17731 histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous) (EC 2.6.1.1; EC 2.6.1.9) from Bacillus subtilis (strain 168)
PFams: Aminotran_1_2, Aminotran_5
360 amino acids: PaperBLAST, CDD (Cluster 1)

Bacteroides thetaiotaomicron

BT0202 histidinol-phosphate aminotransferase (EC 2.6.1.9) from Bacteroides thetaiotaomicron VPI-5482
PFams: Aminotran_1_2, Alliinase_C
346 amino acids: PaperBLAST, CDD (Cluster 1)

Caldanaerobacter subterraneus

HIS8_CALS4 / Q8R5Q4 Histidinol-phosphate aminotransferase; Histidine transaminase; Imidazole acetol-phosphate transaminase; EC 2.6.1.9; EC 2.6.1.38 from Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Q8R5Q4 histidine transaminase (EC 2.6.1.38) from Caldanaerobacter subterraneus subsp. tengcongensis
PFams: Aminotran_1_2, Aminotran_5, Alliinase_C
351 amino acids: PaperBLAST, CDD (Cluster 1)

Desulfovibrio vulgaris

DVU1029 histidinol-phosphate aminotransferase (EC 2.6.1.9) from Desulfovibrio vulgaris Hildenborough JW710
PFams: Aminotran_1_2
373 amino acids: PaperBLAST, CDD (Cluster 2)

DvMF_0908 histidinol-phosphate aminotransferase (EC 2.6.1.9) from Desulfovibrio vulgaris Miyazaki F
PFams: Aminotran_1_2, Aminotran_5
387 amino acids: PaperBLAST, CDD (Cluster 1)

Escherichia coli

b2021 histidinol-phosphate aminotransferase (EC 2.6.1.9) from Escherichia coli K-12 substr. MG1655
P06986 histidinol-phosphate aminotransferase (EC 2.6.1.9) from Escherichia coli (strain K12)
HIS8_ECOLI / P06986 Histidinol-phosphate aminotransferase; Imidazole acetol-phosphate transaminase; HPAT; HspAT; EC 2.6.1.9 from Escherichia coli (strain K12)
PFams: Aminotran_1_2
356 amino acids: PaperBLAST, CDD (Cluster 1)

Marinobacter adhaerens

HP15_2427 histidinol-phosphate aminotransferase (EC 2.6.1.9) from Marinobacter adhaerens HP15
PFams: Aminotran_1_2
350 amino acids: PaperBLAST, CDD (Cluster 1)

Mycobacterium tuberculosis

P9WML7 histidinol-phosphate transaminase (EC 2.6.1.9) from Mycobacterium tuberculosis
PFams: Aminotran_1_2
380 amino acids: PaperBLAST, CDD (Cluster 1)

Nicotiana plumbaginifolia

HIS8_NICPL / Q9FEW2 Histidinol-phosphate aminotransferase, chloroplastic; Imidazole acetol-phosphate transaminase; EC 2.6.1.9 from Nicotiana plumbaginifolia (Leadwort-leaved tobacco) (Tex-Mex tobacco)
PFams: Aminotran_1_2
413 amino acids: PaperBLAST, CDD (Cluster 1)

Nicotiana tabacum

HIS8_TOBAC / O82030 Histidinol-phosphate aminotransferase, chloroplastic; Imidazole acetol-phosphate transaminase; EC 2.6.1.9 from Nicotiana tabacum (Common tobacco)
O82030 histidinol-phosphate transaminase (EC 2.6.1.9) from Nicotiana tabacum
PFams: Aminotran_1_2
413 amino acids: PaperBLAST, CDD (Cluster 1)

Organism unknown

A0A2R7PAQ8 Histidinol-phosphate aminotransferase {ECO:0000256|HAMAP-Rule:MF_01023}; EC=2.6.1.9 {ECO:0000256|HAMAP-Rule:MF_01023}; Imidazole acetol-phosphate transaminase {ECO:0000256|HAMAP-Rule:MF_01023}
373 amino acids: PaperBLAST, CDD (Cluster 1)

A0A975E8Y9 Histidinol-phosphate aminotransferase {ECO:0000256|HAMAP-Rule:MF_01023}; EC=2.6.1.9 {ECO:0000256|HAMAP-Rule:MF_01023}; Imidazole acetol-phosphate transaminase {ECO:0000256|HAMAP-Rule:MF_01023}
377 amino acids: PaperBLAST, CDD (Cluster 1)

HIS8_BACSU Histidinol-phosphate aminotransferase; EC=2.6.1.9; Imidazole acetol-phosphate transaminase
360 amino acids: PaperBLAST, CDD (Cluster 1)

Phaeobacter inhibens

PGA1_c25240 histidinol-phosphate aminotransferase [EC:2.6.1.9] from Phaeobacter inhibens BS107
PFams: Aminotran_1_2, Aminotran_5
361 amino acids: PaperBLAST, CDD (Cluster 1)

Pseudomonas fluorescens

Pf6N2E2_3251 histidinol-phosphate aminotransferase (EC 2.6.1.9) from Pseudomonas fluorescens FW300-N2E2
PFams: Aminotran_1_2
350 amino acids: PaperBLAST, CDD (Cluster 1)

Pseudomonas putida

PP_0967 histidinol-phosphate aminotransferase (EC 2.6.1.9) from Pseudomonas putida KT2440
PFams: Aminotran_1_2
348 amino acids: PaperBLAST, CDD (Cluster 1)

Pseudomonas stutzeri

Psest_3297 histidinol-phosphate aminotransferase (EC 2.6.1.9) from Pseudomonas stutzeri RCH2
PFams: Aminotran_1_2
348 amino acids: PaperBLAST, CDD (Cluster 1)

Schizosaccharomyces pombe

GI|1174375 histidinol-phosphate aminotransferase imidazole acetol phosphate transaminase His3; EC 2.6.1.9 from Schizosaccharomyces pombe
PFams: Aminotran_1_2
384 amino acids: PaperBLAST, CDD (Cluster 1)

Streptomyces griseus

A0A0D3RBW0 tryptophan—pyruvate aminotransferase (EC 2.6.1.99) (from HMM only) from Streptomyces griseus
PFams: Aminotran_1_2
375 amino acids: PaperBLAST, CDD (Cluster 1)

Thermotoga maritima

HIS8_THEMA / Q9X0D0 Histidinol-phosphate aminotransferase; Imidazole acetol-phosphate transaminase; EC 2.6.1.9 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
PFams: Aminotran_1_2
335 amino acids: PaperBLAST, CDD (Cluster 1)

Zymomonas mobilis

HIS8_ZYMMO / P34037 Histidinol-phosphate aminotransferase; Imidazole acetol phosphate aminotransferase; IAP aminotransferase; Imidazole acetol-phosphate transaminase; EC 2.6.1.9 from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
PFams: Aminotran_1_2, DegT_DnrJ_EryC1
369 amino acids: PaperBLAST, CDD (Cluster 2)