GapMind for Amino acid biosynthesis

 

Clusters of Characterized Proteins

Clustering the characterized proteins for hisD (histidinol dehydrogenase) in L-histidine biosynthesis

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Definition of hisD

Fetched 8 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 8 of these sequences

Found 2 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 430-447 amino acids (not heteromeric)

HISTDEHYD-MONOMER histidinal/histidinol dehydrogenase
P06988 Histidinol dehydrogenase; HDH; EC 1.1.1.23
P06988 histidinol dehydrogenase (EC 1.1.1.23)
PFams: Histidinol_dh
434 amino acids: PaperBLAST, CDD, Compare to cluster

Q46N53 Sulfopropanediol 3-dehydrogenase; 2,3-dihydroxypropane-1-sulfonate 3-dehydrogenase (sulfolactate forming); DHPS 3-dehydrogenase (sulfolactate forming); EC 1.1.1.308 (from HMM only)
Q46N53 sulfopropanediol 3-dehydrogenase (EC 1.1.1.308)
PFams: Histidinol_dh
436 amino acids: PaperBLAST, CDD, Compare to cluster

Q8G2R2 histidinol dehydrogenase (EC 1.1.1.23)
PFams: Histidinol_dh
430 amino acids: PaperBLAST, CDD, Compare to cluster

CH_125862 histidinol dehydrogenase His2 (predicted); EC 1.1.1.23
PFams: Histidinol_dh
439 amino acids: PaperBLAST, CDD, Compare to cluster

P10370 Histidinol dehydrogenase; HDH; EC 1.1.1.23
PFams: Histidinol_dh
434 amino acids: PaperBLAST, CDD, Compare to cluster

P9WNW9 Histidinol dehydrogenase; HDH; EC 1.1.1.23
PFams: Histidinol_dh
447 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 799-844 amino acids (not heteromeric)

A1BPP9 histidinol dehydrogenase (EC 1.1.1.23)
PFams: PRA-CH, PRA-PH, Histidinol_dh
844 amino acids: PaperBLAST, CDD, Compare to cluster

P00815 Histidine biosynthesis trifunctional protein; EC 3.5.4.19; EC 3.6.1.31; EC 1.1.1.23
PFams: PRA-CH, PRA-PH, Histidinol_dh
799 amino acids: PaperBLAST, CDD, Compare to cluster