Other Characterized Proteins Similar to hisD

Finding the characterized proteins for hisD (histidinol dehydrogenase) in L-histidine biosynthesis

Or see clustering for step hisD

Or see all steps for L-histidine biosynthesis

Or cluster curated proteins matching a keyword

Definition of hisD

• Curated proteins or TIGRFams with EC 1.1.1.23
• Ignore hits to CH_123581 when looking for 'other' hits (multifunctional enzyme that catalyzes three steps of histidine biosynthesis)

Fetched 8 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 1 other characterized sequences. (Found 9 hits including self hits.)

Removing ignored items reduces this to 0 close sequences.

There are also 1 HMM-only high-coverage hits.

HMM-only sequences

(Since these sequences' annotations are outside the definition for hisD, HMM hits that are over 40% similar to these sequences will be scored as moderate confidence.)

Q46N53 Sulfopropanediol 3-dehydrogenase; 2,3-dihydroxypropane-1-sulfonate 3-dehydrogenase (sulfolactate forming); DHPS 3-dehydrogenase (sulfolactate forming); EC 1.1.1.308
Q46N53 sulfopropanediol 3-dehydrogenase (EC 1.1.1.308)
PFams: Histidinol_dh
436 amino acids: PaperBLAST, CDD

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for hisD.)

CH_123581 multifunctional enzyme that catalyzes three steps of histidine biosynthesis
PFams: PRA-CH, PRA-PH, Histidinol_dh
838 amino acids: PaperBLAST, CDD, CharProtDB::CH_123581
56% identical to

A1BPP9 histidinol dehydrogenase (EC 1.1.1.23)
PFams: PRA-CH, PRA-PH, Histidinol_dh
844 amino acids: PaperBLAST, CDD