Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for hisI (phosphoribosyl-ATP pyrophosphatase) in L-histidine biosynthesis

Or see other characterized proteins similar to hisI

Or see all steps for L-histidine biosynthesis

Or cluster curated proteins matching a keyword

Definition of hisI

Curated proteins or TIGRFams with EC 3.6.1.31
UniProt sequence Q72CU7_DESVH: SubName: Full=MazG family protein {ECO:0000313|EMBL:AAS95664.1};
Ignore hits to CH_123581 when looking for 'other' hits (multifunctional enzyme that catalyzes three steps of histidine biosynthesis)
Comment: Genetic evidence suggests that DVU1186 (Q72CU7_DESVH) is phosphoribosyl-ATP pyrophosphatase (PMC5764234). CH_123581 probably does all three: hisD, hisE, and hisI.

Fetched 7 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 2 of these sequences

Found 1 clusters of similar sequences. Another 5 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 799-844 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

A1BPP9 histidinol dehydrogenase (EC 1.1.1.23) (from HMM only)
PFams: PRA-CH, PRA-PH, Histidinol_dh
844 amino acids: PaperBLAST, CDD, Compare to cluster

P00815 Histidine biosynthesis trifunctional protein; EC 3.5.4.19; EC 3.6.1.31; EC 1.1.1.23
PFams: PRA-CH, PRA-PH, Histidinol_dh
799 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/5 heteromeric)

P9WMM9 phosphoribosyl-ATP diphosphatase (EC 3.6.1.31)
PFams: PRA-PH, MazG
93 amino acids: PaperBLAST, CDD

O59667 Histidine biosynthesis bifunctional protein his7; EC 3.5.4.19; EC 3.6.1.31
CH_124755 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase His7; EC 3.5.4.19; EC 3.6.1.31
PFams: PRA-CH, PRA-PH
417 amino acids: PaperBLAST, CDD

O82768 Histidine biosynthesis bifunctional protein hisIE, chloroplastic; Protein HISTIDINE BIOSYNTHESIS 2; EC 3.5.4.19; EC 3.6.1.31
AT1G31860-MONOMER phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19; EC 3.6.1.31)
PFams: PRA-CH, PRA-PH, MazG
281 amino acids: PaperBLAST, CDD

Q72CU7_DESVH MazG family protein
267 amino acids: PaperBLAST, CDD

HISTCYCLOPRATPPHOS putative bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase (EC 3.5.4.19; EC 3.6.1.31)
HISTCYCLOPRATPPHOS phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19; EC 3.6.1.31)
PFams: PRA-CH, PRA-PH
203 amino acids: PaperBLAST, CDD