Other Characterized Proteins Similar to hisI

Finding the characterized proteins for hisI (phosphoribosyl-ATP pyrophosphatase) in L-histidine biosynthesis

Or see clustering for step hisI

Or see all steps for L-histidine biosynthesis

Or cluster curated proteins matching a keyword

Definition of hisI

• Curated proteins or TIGRFams with EC 3.6.1.31
• Ignore hits to CH_123581 when looking for 'other' hits (multifunctional enzyme that catalyzes three steps of histidine biosynthesis)
• Ignore hits to A1BPP9 when looking for 'other' hits (histidinol dehydrogenase (EC 1.1.1.23))
• Comment: CH_123581 and A1BPP9 probably do all three: hisD, hisE, and hisI.

Fetched 18 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 2 other characterized sequences. (Found 20 hits including self hits.)

Removing ignored items reduces this to 0 close sequences.

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for hisI.)

A1BPP9 histidinol dehydrogenase (EC 1.1.1.23) from Geotrichum candidum
PFams: PRA-CH, PRA-PH, Histidinol_dh
844 amino acids: PaperBLAST, CDD, BRENDA::A1BPP9
63% identical to

HIS2_YEAST / P00815 Histidine biosynthesis trifunctional protein; EC 3.5.4.19; EC 3.6.1.31; EC 1.1.1.23 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: PRA-CH, PRA-PH, Histidinol_dh
799 amino acids: PaperBLAST, CDD

CH_123581 multifunctional enzyme that catalyzes three steps of histidine biosynthesis from Candida albicans
PFams: PRA-CH, PRA-PH, Histidinol_dh
838 amino acids: PaperBLAST, CDD, CharProtDB::CH_123581
53% identical to

HIS2_YEAST / P00815 Histidine biosynthesis trifunctional protein; EC 3.5.4.19; EC 3.6.1.31; EC 1.1.1.23 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: PRA-CH, PRA-PH, Histidinol_dh
799 amino acids: PaperBLAST, CDD