Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for hisI (phosphoribosyl-ATP pyrophosphatase) in L-histidine biosynthesis

Or see other characterized proteins similar to hisI

Or see all steps for L-histidine biosynthesis

Or cluster curated proteins matching a keyword

Definition of hisI

Curated proteins or TIGRFams with EC 3.6.1.31
Ignore hits to CH_123581 when looking for 'other' hits (multifunctional enzyme that catalyzes three steps of histidine biosynthesis)
Ignore hits to A1BPP9 when looking for 'other' hits (histidinol dehydrogenase (EC 1.1.1.23))
Comment: CH_123581 and A1BPP9 probably do all three: hisD, hisE, and hisI.

Fetched 18 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 13 of these sequences

Found 1 clusters of similar sequences. Another 5 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 93-131 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

Ga0059261_1051 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) from Sphingomonas koreensis DSMZ 15582
PFams: PRA-PH
107 amino acids: PaperBLAST, CDD, Compare to cluster

P9WMM9 phosphoribosyl-ATP diphosphatase (EC 3.6.1.31) from Mycobacterium tuberculosis
PFams: PRA-PH, MazG
93 amino acids: PaperBLAST, CDD, Compare to cluster

BPHYT_RS17670 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) from Burkholderia phytofirmans PsJN
PFams: PRA-PH
131 amino acids: PaperBLAST, CDD, Compare to cluster

CCNA_03854 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) from Caulobacter crescentus NA1000
PFams: PRA-PH
107 amino acids: PaperBLAST, CDD, Compare to cluster

HP15_3195 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) from Marinobacter adhaerens HP15
PFams: PRA-PH
109 amino acids: PaperBLAST, CDD, Compare to cluster

PP_5015 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) from Pseudomonas putida KT2440
PFams: PRA-PH
111 amino acids: PaperBLAST, CDD, Compare to cluster

PS417_01850 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) from Pseudomonas simiae WCS417
PFams: PRA-PH
110 amino acids: PaperBLAST, CDD, Compare to cluster

AZOBR_RS01690 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) from Azospirillum brasilense Sp245
PFams: PRA-PH
113 amino acids: PaperBLAST, CDD, Compare to cluster

Psest_3944 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) from Pseudomonas stutzeri RCH2
PFams: PRA-PH
110 amino acids: PaperBLAST, CDD, Compare to cluster

PfGW456L13_303 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) from Pseudomonas fluorescens GW456-L13
PFams: PRA-PH
110 amino acids: PaperBLAST, CDD, Compare to cluster

Pf1N1B4_1566 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) from Pseudomonas fluorescens FW300-N1B4
PFams: PRA-PH
110 amino acids: PaperBLAST, CDD, Compare to cluster

AO353_12360 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) from Pseudomonas fluorescens FW300-N2E3
PFams: PRA-PH
110 amino acids: PaperBLAST, CDD, Compare to cluster

AO356_09525 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) from Pseudomonas fluorescens FW300-N2C3
Pf6N2E2_3783 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) from Pseudomonas fluorescens FW300-N2E2
PFams: PRA-PH
110 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/5 heteromeric)

HIS2_SCHPO / O59667 Histidine biosynthesis bifunctional protein his7; EC 3.5.4.19; EC 3.6.1.31 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
GI|3006138 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase His7; EC 3.5.4.19; EC 3.6.1.31 from Schizosaccharomyces pombe
PFams: PRA-CH, PRA-PH
417 amino acids: PaperBLAST, CDD

O82768 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19; EC 3.6.1.31) from Arabidopsis thaliana
HIS2_ARATH / O82768 Histidine biosynthesis bifunctional protein hisIE, chloroplastic; Protein HISTIDINE BIOSYNTHESIS 2; EC 3.5.4.19; EC 3.6.1.31 from Arabidopsis thaliana (Mouse-ear cress)
PFams: PRA-CH, PRA-PH
281 amino acids: PaperBLAST, CDD

HIS2_YEAST / P00815 Histidine biosynthesis trifunctional protein; EC 3.5.4.19; EC 3.6.1.31; EC 1.1.1.23 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: PRA-CH, PRA-PH, Histidinol_dh
799 amino acids: PaperBLAST, CDD

P06989 putative bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase (EC 3.5.4.19; EC 3.6.1.31) from Escherichia coli (strain K12)
PFams: PRA-CH, PRA-PH
203 amino acids: PaperBLAST, CDD

DVU1186 phosphoribosyl-ATP diphosphatase (EC 3.6.1.31) from Desulfovibrio vulgaris Hildenborough JW710
Q72CU7 phosphoribosyl-ATP diphosphatase (EC 3.6.1.31) from Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough)
PFams: MazG
267 amino acids: PaperBLAST, CDD