Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for hisN (histidinol-phosphate phosphatase) in L-histidine biosynthesis

Or see other characterized proteins similar to hisN

Or see all steps for L-histidine biosynthesis

Or cluster curated proteins matching a keyword

Definition of hisN

Curated proteins or TIGRFams with EC 3.1.3.15
UniProt sequence B9E9Z0_MACCJ: RecName: Full=Histidinol-phosphatase {ECO:0000256|ARBA:ARBA00013085, ECO:0000256|RuleBase:RU366003}; Short=HolPase {ECO:0000256|RuleBase:RU366003}; EC=3.1.3.15 {ECO:0000256|ARBA:ARBA00013085, ECO:0000256|RuleBase:RU366003};
UniProt sequence C0ZH63_BREBN: RecName: Full=Histidinol-phosphatase {ECO:0000256|ARBA:ARBA00013085, ECO:0000256|RuleBase:RU366003}; Short=HolPase {ECO:0000256|RuleBase:RU366003}; EC=3.1.3.15 {ECO:0000256|ARBA:ARBA00013085, ECO:0000256|RuleBase:RU366003};
UniProt sequence Q73B87_BACC1: RecName: Full=Histidinol-phosphatase {ECO:0000256|ARBA:ARBA00013085, ECO:0000256|RuleBase:RU366003}; Short=HolPase {ECO:0000256|RuleBase:RU366003}; EC=3.1.3.15 {ECO:0000256|ARBA:ARBA00013085, ECO:0000256|RuleBase:RU366003};
UniProt sequence A9VLI0_BACMK: RecName: Full=Histidinol-phosphatase {ECO:0000256|ARBA:ARBA00013085, ECO:0000256|RuleBase:RU366003}; Short=HolPase {ECO:0000256|RuleBase:RU366003}; EC=3.1.3.15 {ECO:0000256|ARBA:ARBA00013085, ECO:0000256|RuleBase:RU366003};
UniProt sequence HIS9_BACHD: RecName: Full=Histidinol-phosphatase; Short=HolPase; EC=3.1.3.15;
UniProt sequence Q5KW52_GEOKA: RecName: Full=Histidinol-phosphatase {ECO:0000256|ARBA:ARBA00013085, ECO:0000256|RuleBase:RU366003}; Short=HolPase {ECO:0000256|RuleBase:RU366003}; EC=3.1.3.15 {ECO:0000256|ARBA:ARBA00013085, ECO:0000256|RuleBase:RU366003};
UniProt sequence Q8DT80_STRMU: RecName: Full=Histidinol-phosphatase {ECO:0000256|RuleBase:RU366003}; Short=HolPase {ECO:0000256|RuleBase:RU366003}; EC=3.1.3.15 {ECO:0000256|RuleBase:RU366003};
UniProt sequence HIS9_BACSU: RecName: Full=Histidinol-phosphatase; Short=HolPase; EC=3.1.3.15;
UniProt sequence A0A0L7BRC5: SubName: Full=HAD family hydrolase {ECO:0000313|EMBL:KOA49733.1};
Ignore hits to S5FT07 when looking for 'other' hits (Carbon disulfide hydrolase; CS(2) hydrolase; EC 3.13.1.5. carbon disulfide hydrolase (EC 3.13.1.5))
Ignore hits to S5FU55 when looking for 'other' hits (Carbon disulfide hydrolase; CS(2) hydrolase; EC 3.13.1.5. carbon disulfide hydrolase (EC 3.13.1.5))
Ignore hits to ALKAPHOSPHA-MONOMER when looking for 'other' hits (alkaline phosphatase (EC 3.1.3.1). alkaline phosphatase (EC 3.1.3.1; EC 3.1.3.75; EC 3.1.3.41; EC 3.1.3.74; EC 3.1.3.99; EC 3.1.3.5; EC 3.1.3.6; EC 3.1.3.89; EC 3.1.3.91; EC 3.1.3.60; EC 3.1.3.15; EC 3.1.3.102; EC 3.1.3.108; EC 3.1.3.11; EC 3.1.3.20; EC 3.1.3.19; EC 3.1.3.3; EC 3.6.1.25; EC 3.6.1.1; EC 3.1.3.23; EC 3.1.3.38; EC 3.1.3.18; EC 3.1.3.68; EC 3.9.1.1). alkaline phosphatase (EC 3.1.3.1; EC 3.1.3.75; EC 3.1.3.41; EC 3.1.3.74; EC 3.1.3.99; EC 3.1.3.5; EC 3.1.3.6; EC 3.1.3.89; EC 3.1.3.91; EC 3.1.3.60; EC 3.1.3.15; EC 3.1.3.102; EC 3.1.3.108; EC 3.1.3.11; EC 3.1.3.20; EC 3.1.3.19; EC 3.1.3.3; EC 3.6.1.25; EC 3.6.1.1; EC 3.1.3.23; EC 3.1.3.38; EC 3.1.3.18; EC 3.1.3.68; EC 3.9.1.1))
Comment: In Bacillus subtilis and some related bacteria, histidinol-phosphate phosphatase is known as HisJ and has been confirmed by biochemical assays of purified proteins (PMC3570733). The identifiers given (see their Table 3) are MCCL_0344 BBR47_00270 BCE_1533 BcerKBAB4_1335 BcerKBAB4_1335 BSU29620 BH3206 GK2799 SMU_1486c (B9E9Z0_MACCJ C0ZH63_BREBN Q73B87_BACC1 A9VLI0_BACMK HIS9_BACHD Q5KW52_GEOKA Q8DT80_STRMU HIS9_BACSU). In Bifidobacterium breve, the phosphatase activity is provided by Bbr_0982 (A0A0L7BRC5, link). S5FT07 and S5FU55 are misannotated as this in BRENDA. E. coli phoA (link) has this activity but is ignored because it is periplasmic.

Fetched 31 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 26 of these sequences

Found 5 clusters of similar sequences. Another 6 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 250-326 amino acids (not heteromeric)

PGA1_c21860 Histidinol-phosphatase [alternative form] (EC 3.1.3.15) from Phaeobacter inhibens BS107
PFams: Inositol_P
250 amino acids: PaperBLAST, CDD, Compare to cluster

G7J7Q5 histidinol-phosphatase (EC 3.1.3.15); inositol-phosphate phosphatase (EC 3.1.3.25) from Medicago truncatula
PFams: Inositol_P
326 amino acids: PaperBLAST, CDD, Compare to cluster

HISN_MYCTU / P95189 Histidinol-phosphatase; HolPase; Histidinol-phosphate phosphatase; EC 3.1.3.15 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P95189 histidinol-phosphatase (EC 3.1.3.15) from Mycobacterium tuberculosis
PFams: Inositol_P
260 amino acids: PaperBLAST, CDD, Compare to cluster

Q8NS79 histidinol-phosphatase (EC 3.1.3.15) from Corynebacterium glutamicum
PFams: Inositol_P
273 amino acids: PaperBLAST, CDD, Compare to cluster

Q8NS80 histidinol-phosphatase (EC 3.1.3.15) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
HISN_CORGL / Q8NS80 Histidinol-phosphatase; HolPase; Histidinol-phosphate phosphatase; EC 3.1.3.15 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
Q8NS80 histidinol-phosphatase (EC 3.1.3.15) from Corynebacterium glutamicum
PFams: Inositol_P
260 amino acids: PaperBLAST, CDD, Compare to cluster

HISN_STRCO / Q9K4B1 Histidinol-phosphatase; HolPase; Histidinol-phosphate phosphatase; EC 3.1.3.15 from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
PFams: Inositol_P
266 amino acids: PaperBLAST, CDD, Compare to cluster

Ga0059261_2035 Histidinol-phosphatase [alternative form] (EC 3.1.3.15) from Sphingomonas koreensis DSMZ 15582
PFams: Inositol_P
260 amino acids: PaperBLAST, CDD, Compare to cluster

AZOBR_RS03845 Histidinol-phosphatase [alternative form] (EC 3.1.3.15) from Azospirillum brasilense Sp245
PFams: Inositol_P
260 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 267-339 amino acids (not heteromeric)

C0ZH63_BREBN Histidinol-phosphatase {ECO:0000256|ARBA:ARBA00013085, ECO:0000256|RuleBase:RU366003}; Short=HolPase {ECO:0000256|RuleBase:RU366003}; EC=3.1.3.15 {ECO:0000256|ARBA:ARBA00013085, ECO:0000256|RuleBase:RU366003}
334 amino acids: PaperBLAST, CDD, Compare to cluster

A9VLI0_BACMK Histidinol-phosphatase {ECO:0000256|ARBA:ARBA00013085, ECO:0000256|RuleBase:RU366003}; Short=HolPase {ECO:0000256|RuleBase:RU366003}; EC=3.1.3.15 {ECO:0000256|ARBA:ARBA00013085, ECO:0000256|RuleBase:RU366003}
339 amino acids: PaperBLAST, CDD, Compare to cluster

B9E9Z0_MACCJ Histidinol-phosphatase {ECO:0000256|ARBA:ARBA00013085, ECO:0000256|RuleBase:RU366003}; Short=HolPase {ECO:0000256|RuleBase:RU366003}; EC=3.1.3.15 {ECO:0000256|ARBA:ARBA00013085, ECO:0000256|RuleBase:RU366003}
335 amino acids: PaperBLAST, CDD, Compare to cluster

Q73B87_BACC1 Histidinol-phosphatase {ECO:0000256|ARBA:ARBA00013085, ECO:0000256|RuleBase:RU366003}; Short=HolPase {ECO:0000256|RuleBase:RU366003}; EC=3.1.3.15 {ECO:0000256|ARBA:ARBA00013085, ECO:0000256|RuleBase:RU366003}
338 amino acids: PaperBLAST, CDD, Compare to cluster

Q5SLG2 histidinol phosphate phosphatase subunit (EC 3.1.3.15) from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
PFams: PHP, PHP_C
267 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 217-228 amino acids (not heteromeric)

HIS9_NEIM8 / P0DV34 Histidinol-phosphatase; Hol-Pase; Histidinol-phosphate phosphatase; EC 3.1.3.15 from Neisseria meningitidis serogroup C (strain 8013)
PFams: Hydrolase, HAD
222 amino acids: PaperBLAST, CDD, Compare to cluster

HIS9_PSEAE / Q9I6F6 Histidinol-phosphatase; Hol-Pase; Histidinol-phosphate phosphatase; EC 3.1.3.15 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PFams: Hydrolase, HAD
217 amino acids: PaperBLAST, CDD, Compare to cluster

BPHYT_RS03625 Histidinol-phosphatase (EC:3.1.3.15) from Burkholderia phytofirmans PsJN
PFams: HAD
228 amino acids: PaperBLAST, CDD, Compare to cluster

HP15_461 Histidinol-phosphatase (EC:3.1.3.15) from Marinobacter adhaerens HP15
PFams: Hydrolase, HAD
218 amino acids: PaperBLAST, CDD, Compare to cluster

Psest_3864 Histidinol-phosphatase (EC:3.1.3.15) from Pseudomonas stutzeri RCH2
PFams: HAD
217 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 4 355-382 amino acids (not heteromeric)

HIS7_SPILD / D2QPE6 Histidine biosynthesis bifunctional protein HisB; EC 3.1.3.15; EC 4.2.1.19 from Spirosoma linguale (strain ATCC 33905 / DSM 74 / LMG 10896 / Claus 1)
PFams: PNK3P, Hydrolase_like, IGPD
382 amino acids: PaperBLAST, CDD, Compare to cluster

HIS7_BACTN / Q8ABA7 Histidine biosynthesis bifunctional protein HisB; EC 3.1.3.15; EC 4.2.1.19 from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)
PFams: Hydrolase_like, IGPD
374 amino acids: PaperBLAST, CDD, Compare to cluster

HIS7_ECO57 / Q9S5G5 Histidine biosynthesis bifunctional protein HisB; EC 3.1.3.15; EC 4.2.1.19 from Escherichia coli O157:H7
PFams: PNK3P, Hydrolase_like, IGPD
355 amino acids: PaperBLAST, CDD, Compare to cluster

b2022 imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (EC 4.2.1.19; EC 3.1.3.15) from Escherichia coli K-12 substr. MG1655
P06987 imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (EC 4.2.1.19; EC 3.1.3.15) from Escherichia coli (strain K12)
PFams: PNK3P, Hydrolase_like, IGPD
355 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 5 268-274 amino acids (not heteromeric)

HIS9_BACHD Histidinol-phosphatase; Short=HolPase; EC=3.1.3.15
273 amino acids: PaperBLAST, CDD, Compare to cluster

HIS9_BACSU Histidinol-phosphatase; Short=HolPase; EC=3.1.3.15
268 amino acids: PaperBLAST, CDD, Compare to cluster

Q5KW52_GEOKA Histidinol-phosphatase {ECO:0000256|ARBA:ARBA00013085, ECO:0000256|RuleBase:RU366003}; Short=HolPase {ECO:0000256|RuleBase:RU366003}; EC=3.1.3.15 {ECO:0000256|ARBA:ARBA00013085, ECO:0000256|RuleBase:RU366003}
274 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/6 heteromeric)

B1PRL6 histidinol-phosphatase (EC 3.1.3.15) from Thermococcus onnurineus NA1
240 amino acids: PaperBLAST, CDD

Q02150 histidinol-phosphatase (EC 3.1.3.15) from Lactococcus lactis subsp. lactis
PFams: PHP
269 amino acids: PaperBLAST, CDD

Q6NPM8 histidinol phosphate phosphatase (EC 3.1.3.15; EC 3.1.3.93; EC 3.1.3.25) from Arabidopsis thaliana
HIS7_ARATH / Q6NPM8 Bifunctional phosphatase IMPL2, chloroplastic; Histidinol-phosphatase; Histidinol-phosphate phosphatase; HPP; Inositol-phosphate phosphatase; L-galactose 1-phosphate phosphatase; Protein HISTIDINE BIOSYNTHESIS 7; Protein MYO-INOSITOL MONOPHOSPHATASE-LIKE 2; EC 3.1.3.15; EC 3.1.3.25; EC 3.1.3.93 from Arabidopsis thaliana (Mouse-ear cress)
Q6NPM8 histidinol-phosphatase (EC 3.1.3.15); inositol-phosphate phosphatase (EC 3.1.3.25) from Arabidopsis thaliana
PFams: Inositol_P
346 amino acids: PaperBLAST, CDD
(similar to BRENDA::G7J7Q5 from Cluster 1, but similarity to seed sequence is below thresholds)

HIS9_YEAST / P38635 Histidinol-phosphatase; HolPase; EC 3.1.3.15 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: PHP
335 amino acids: PaperBLAST, CDD

A0A0L7BRC5 HAD family hydrolase
209 amino acids: PaperBLAST, CDD

Q8DT80_STRMU Histidinol-phosphatase {ECO:0000256|RuleBase:RU366003}; Short=HolPase {ECO:0000256|RuleBase:RU366003}; EC=3.1.3.15 {ECO:0000256|RuleBase:RU366003}
244 amino acids: PaperBLAST, CDD