Other Characterized Proteins Similar to cimA

GapMind for Amino acid biosynthesis

Other Characterized Proteins Similar to cimA

Finding the characterized proteins for cimA ((R)-citramalate synthase) in L-isoleucine biosynthesis

Or see clustering for step cimA

Or see all steps for L-isoleucine biosynthesis

Or cluster curated proteins matching a keyword

Definition of cimA

Curated proteins or TIGRFams with EC 2.3.1.182
Curated proteins or TIGRFams with EC 2.3.3.21
UniProt sequence Q8F3Q1: RecName: Full=(R)-citramalate synthase CimA {ECO:0000305}; EC=2.3.3.21 {ECO:0000269|PubMed:15292141, ECO:0000269|PubMed:18498255, ECO:0000269|PubMed:19351325}; AltName: Full=LiCMS {ECO:0000303|PubMed:18498255};
UniProt sequence D4GSQ2: SubName: Full=2-isopropylmalate synthase / (R)-citramalate synthase {ECO:0000313|EMBL:ADE04954.1}; EC=2.3.1.182 {ECO:0000313|EMBL:ADE04954.1}; EC=2.3.3.13 {ECO:0000313|EMBL:ADE04954.1};
Comment: MetaCyc L-isoleucine biosynthesis II describes the formation of 2-oxobutanoate via citramalate. The other steps are the same (although it gives a different EC number for ilvC because of different cofactor preference) The citramalate synthase from Leptopsira interrogans (LA_2350, NP_712531, or Q8F3Q1) has been characterized biochemically but is not in the curated databases, see PMID:18498255 The putative citramalate synthase HVO_0644 (D4GSQ2) from Haloferax volcanii is required for isoleucine biosynthesis, see PMC4300041.

Fetched 9 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 18 other characterized sequences. (Found 25 hits including self hits.)

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for cimA.)

LEU1_METJA / Q58595 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Q58595 2-isopropylmalate synthase (EC 2.3.3.13) from Methanocaldococcus jannaschii
PFams: HMGL-like, LeuA_dimer
518 amino acids: PaperBLAST, CDD, BRENDA::Q58595
51% identical to

Q58787 (R)-citratemalate synthase subunit (EC 2.3.3.21) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
CIMA_METJA / Q58787 (R)-citramalate synthase CimA; EC 2.3.3.21 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Q58787 (R)-citramalate synthase (EC 2.3.3.21) from Methanocaldococcus jannaschii
PFams: HMGL-like, LeuA_dimer
491 amino acids: PaperBLAST, CDD

Q72JC9 2-isopropylmalate synthase (EC 2.3.3.13) from Thermus thermophilus
PFams: HMGL-like, LeuA_dimer
520 amino acids: PaperBLAST, CDD, BRENDA::Q72JC9
42% identical to

LEU11_LEPIN / Q8F445 2-isopropylmalate synthase 1; Alpha-IPM synthase 1; Alpha-isopropylmalate synthase 1; EC 2.3.3.13 from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
PFams: HMGL-like, LeuA_dimer
501 amino acids: PaperBLAST, CDD, SwissProt::Q8F445
42% identical to

BT1861 2-isopropylmalate synthase (EC 2.3.3.13) from Bacteroides thetaiotaomicron VPI-5482
PFams: HMGL-like, LeuA_dimer
498 amino acids: PaperBLAST, CDD, reanno::Btheta:351389
42% identical to

LEU1_NEIMB / Q9JZG1 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Neisseria meningitidis serogroup B (strain MC58)
Q9JZG1 2-isopropylmalate synthase (EC 2.3.3.13) from Neisseria meningitidis
PFams: HMGL-like, LeuA_dimer
517 amino acids: PaperBLAST, CDD, BRENDA::Q9JZG1
42% identical to

LEU1_SULAC / Q4JA78 2-isopropylmalate synthase; IPMS; Alpha-isopropylmalate synthase; Alpha-IPM synthase; EC 2.3.3.13 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
PFams: HMGL-like
386 amino acids: PaperBLAST, CDD, SwissProt::Q4JA78
53% identical to

AKSA_METJA / Q57926 Homocitrate synthase AksA; (R)-homo(2)citrate synthase; (R)-homo(3)citrate synthase; EC 2.3.3.14; EC 2.3.3.- from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
PFams: HMGL-like
406 amino acids: PaperBLAST, CDD, SwissProt::Q57926
52% identical to

Q2RAP8 2-isopropylmalate synthase (EC 2.3.3.13) from Oryza sativa Japonica Group
PFams: HMGL-like, LeuA_dimer
635 amino acids: PaperBLAST, CDD, BRENDA::Q2RAP8
40% identical to

Q2QXY9 2-isopropylmalate synthase (EC 2.3.3.13) from Oryza sativa Japonica Group
PFams: HMGL-like, LeuA_dimer
635 amino acids: PaperBLAST, CDD, BRENDA::Q2QXY9
40% identical to

Q9FN52 methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana
MAM3_ARATH / Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic; 2-isopropylmalate synthase 2; Methylthioalkylmalate synthase-like; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress)
Q9FN52 2-isopropylmalate synthase (EC 2.3.3.13); methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana
PFams: HMGL-like
503 amino acids: PaperBLAST, CDD, BRENDA::Q9FN52
44% identical to

Echvi_3833 2-isopropylmalate synthase (EC 2.3.3.13) from Echinicola vietnamensis KMM 6221, DSM 17526
PFams: HMGL-like
390 amino acids: PaperBLAST, CDD, reanno::Cola:Echvi_3833
45% identical to

CA265_RS15855 2-isopropylmalate synthase (EC 2.3.3.13) from Pedobacter sp. GW460-11-11-14-LB5
PFams: HMGL-like
386 amino acids: PaperBLAST, CDD, reanno::Pedo557:CA265_RS15855
45% identical to

Q9FG67 methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana
MAM1_ARATH / Q9FG67 Methylthioalkylmalate synthase 1, chloroplastic; 2-isopropylmalate synthase 3; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress)
Q9FG67 2-isopropylmalate synthase (EC 2.3.3.13); methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana
PFams: HMGL-like
506 amino acids: PaperBLAST, CDD, BRENDA::Q9FG67
41% identical to

MAM2_ARATH / Q8VX04 Methylthioalkylmalate synthase 2, chloroplastic; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress)
Q8VX04 methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana
PFams: HMGL-like
506 amino acids: PaperBLAST, CDD, SwissProt::Q8VX04
41% identical to

K4CJ56 2-isopropylmalate synthase (EC 2.3.3.13) from Solanum lycopersicum
PFams: HMGL-like
445 amino acids: PaperBLAST, CDD, BRENDA::K4CJ56
43% identical to

P58637 homocitrate synthase (EC 2.3.3.14) from Nostoc sp. PCC 7120 = FACHB-418
PFams: HMGL-like
376 amino acids: PaperBLAST, CDD, BRENDA::P58637
41% identical to

Q0ZQ46 2-phosphonomethylmalate synthase (EC 2.3.3.19) from Streptomyces rubellomurinus (strain ATCC 31215)
FRBC_STRR3 / Q0ZQ46 2-phosphonomethylmalate synthase; EC 2.3.3.19 from Streptomyces rubellomurinus (strain ATCC 31215)
Q0ZQ46 2-phosphonomethylmalate synthase (EC 2.3.3.19) from Streptomyces rubellomurinus
PFams: HMGL-like
373 amino acids: PaperBLAST, CDD, SwissProt::Q0ZQ46
40% identical to

A0A0S6UXF5 homocitrate synthase (EC 2.3.3.14) from Bradyrhizobium sp. DOA9
PFams: HMGL-like
400 amino acids: PaperBLAST, CDD, BRENDA::A0A0S6UXF5
40% identical to