Other Characterized Proteins Similar to ilvE

GapMind for Amino acid biosynthesis

Other Characterized Proteins Similar to ilvE

Finding the characterized proteins for ilvE (isoleucine transaminase) in L-isoleucine biosynthesis

Or see clustering for step ilvE

Or see all steps for L-isoleucine biosynthesis

Or cluster curated proteins matching a keyword

Definition of ilvE

Curated proteins or TIGRFams with EC 2.6.1.42
Ignore hits to Q8NS92 when looking for 'other' hits (HTH-type pyridoxine biosynthesis transcriptional regulator PdxR)
Ignore hits to items matching 2.6.1.57 when looking for 'other' hits
Ignore hits to items matching 2.6.1.5 when looking for 'other' hits
Comment: Q8NS92 is ignored because it is primarily a transcriptional regulator. Similarity to aromatic amino acid transaminases or tyrosine transaminases is ignored as they often are often non-specific.

Fetched 60 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 37 other characterized sequences. (Found 97 hits including self hits.)

Removing ignored items reduces this to 26 close sequences.

There are also 1 HMM-only high-coverage hits.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for ilvE.)

O57946 kynurenine-oxoglutarate transaminase (EC 2.6.1.7) from Pyrococcus horikoshii
PFams: Aminotran_1_2, Asp_aminotransf
428 amino acids: PaperBLAST, CDD, BRENDA::O57946
75% identical to

A0A060PQX5 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Thermococcus sp.
PFams: Aminotran_1_2, Asp_aminotransf
417 amino acids: PaperBLAST, CDD

Q5P8C9 aromatic-amino-acid aminotransferase (EC 2.6.1.1) from Aromatoleum aromaticum (strain EbN1)
PFams: Aminotran_1_2
404 amino acids: PaperBLAST, CDD, metacyc::PHETRANTHAUERA-MONOMER
64% identical to

b4054 tyrosine aminotransferase (EC 2.6.1.57; EC 2.6.1.6; EC 2.6.1.42; EC 2.6.1.1; EC 2.6.1.5; EC 2.6.1.27) from Escherichia coli K-12 substr. MG1655
P04693 tyrosine aminotransferase (EC 2.6.1.57; EC 2.6.1.6; EC 2.6.1.1) from Escherichia coli (strain K12)
TYRB_ECOLI / P04693 Aromatic-amino-acid aminotransferase; ARAT; AROAT; Beta-methylphenylalanine transaminase; EC 2.6.1.57; EC 2.6.1.107 from Escherichia coli (strain K12)
P04693 aromatic-amino-acid transaminase (EC 2.6.1.57) from Escherichia coli
GB|AAC77024.1 aromatic-amino-acid transaminase TyrB; EC 2.6.1.57 from Escherichia coli K12
PFams: Aminotran_1_2
397 amino acids: PaperBLAST, CDD

K0E3V3 4-(4-hydroxyphenyl)-2-oxobutanoate transaminase from Aspergillus rugulosus
HTYB_ASPRU / K0E3V3 Transaminase htyB; L-homotyrosine biosynthetic cluster protein B; EC 2.6.1.- from Aspergillus rugulosus (Emericella rugulosa)
PFams: Aminotran_4
379 amino acids: PaperBLAST, CDD, SwissProt::K0E3V3
64% identical to

GLOG_GLAL2 / S3DQP8 Branched-chain amino acid aminotransferase gloG; L-homotyrosine biosynthesis sub-cluster protein gloG; Pneumocandin biosynthesis cluster protein G; EC 2.6.1.42 from Glarea lozoyensis (strain ATCC 20868 / MF5171)
PFams: Aminotran_4
358 amino acids: PaperBLAST, CDD

AMT5_ALTAL / C9K7B6 Transaminase AMT5; AM-toxin biosynthesis protein 5; EC 2.6.1.- from Alternaria alternata (Alternaria rot fungus) (Torula alternata)
PFams: Aminotran_4
373 amino acids: PaperBLAST, CDD, SwissProt::C9K7B6
55% identical to

AMT52_ALTAL / C9K7D8 Transaminase AMT5-2; AM-toxin biosynthesis protein 5-2; EC 2.6.1.- from Alternaria alternata (Alternaria rot fungus) (Torula alternata)
PFams: Aminotran_4
373 amino acids: PaperBLAST, CDD, SwissProt::C9K7D8
54% identical to

W0PFQ7 aspartate transaminase (EC 2.6.1.1) from Advenella mimigardefordensis
PFams: Aminotran_1_2
399 amino acids: PaperBLAST, CDD, BRENDA::W0PFQ7
50% identical to

POXL_PENOX / A0A1W5T1Y5 Aminotransferase poxL; Oxaleimides biosynthesis cluster protein L; EC 2.6.1.- from Penicillium oxalicum
PFams: Aminotran_4
365 amino acids: PaperBLAST, CDD, SwissProt::A0A1W5T1Y5
47% identical to

POXL_PENO1 / S7ZEI5 Aminotransferase poxL; Oxaleimides biosynthesis cluster protein L; EC 2.6.1.- from Penicillium oxalicum (strain 114-2 / CGMCC 5302) (Penicillium decumbens)
PFams: Aminotran_4
365 amino acids: PaperBLAST, CDD, SwissProt::S7ZEI5
47% identical to

LCSP_PURLI / A0A179HME7 Aminotransferase lcsP; Leucinostatins biosynthesis cluster protein P; EC 2.6.1.- from Purpureocillium lilacinum (Paecilomyces lilacinus)
PFams: Aminotran_4
387 amino acids: PaperBLAST, CDD, SwissProt::A0A179HME7
46% identical to

ATNJ_EMENI / Q5AV04 Aminotransferase atnJ; Aspercryptin biosynthesis cluster protein J; EC 2.6.1.- from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
PFams: Aminotran_4
348 amino acids: PaperBLAST, CDD, SwissProt::Q5AV04
49% identical to

P43336 tyrosine aminotransferase subunit (EC 2.6.1.1) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PFams: Aminotran_1_2
399 amino acids: PaperBLAST, CDD, metacyc::MONOMER-12023
45% identical to

Q5SL82 L-2-aminoadipate aminotransferase monomer (EC 2.6.1.39) from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
PFams: Aminotran_1_2, Asp_aminotransf
397 amino acids: PaperBLAST, CDD, metacyc::MONOMER-6727
45% identical to

Ac3H11_1358 L-leucine transaminase; L-isoleucine transaminase (EC 2.6.1.42) from Acidovorax sp. GW101-3H11
PFams: Aminotran_1_2, Asp_aminotransf
401 amino acids: PaperBLAST, CDD

LYSN_THET2 / Q72LL6 2-aminoadipate transaminase; 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT; EC 2.6.1.39 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
Q72LL6 2-aminoadipate transaminase (EC 2.6.1.39) from Thermus thermophilus
PFams: Aminotran_1_2, Asp_aminotransf
397 amino acids: PaperBLAST, CDD, BRENDA::Q72LL6
45% identical to

Ac3H11_1358 L-leucine transaminase; L-isoleucine transaminase (EC 2.6.1.42) from Acidovorax sp. GW101-3H11
PFams: Aminotran_1_2, Asp_aminotransf
401 amino acids: PaperBLAST, CDD

GRA16_GIBZE / I1R9B6 Aminotransferase FGSG_00049; Gramillins biosynthesis cluster protein FGSG_00049; EC 2.6.1.- from Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum)
PFams: Aminotran_4
382 amino acids: PaperBLAST, CDD, SwissProt::I1R9B6
45% identical to

APF4_GIBF5 / S0DS11 Aminotransferase apf4; Apicidin F synthesis protein 4; EC 2.6.1.- from Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae and foot rot disease fungus) (Fusarium fujikuroi)
PFams: Aminotran_4
378 amino acids: PaperBLAST, CDD, SwissProt::S0DS11
44% identical to

TOXF_COCCA / Q9Y885 Aminotransferase TOXF; TOX2 HC-toxin biosynthesis cluster protein TOXF; EC 2.6.1.- from Cochliobolus carbonum (Maize leaf spot fungus) (Bipolaris zeicola)
PFams: Aminotran_4
357 amino acids: PaperBLAST, CDD, SwissProt::Q9Y885
44% identical to

AAT5_ARATH / P46248 Aspartate aminotransferase, chloroplastic; Transaminase A; EC 2.6.1.1 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Aminotran_1_2
453 amino acids: PaperBLAST, CDD, SwissProt::P46248
41% identical to

AATM_MOUSE / P05202 Aspartate aminotransferase, mitochondrial; mAspAT; Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Plasma membrane-associated fatty acid-binding protein; FABPpm; Transaminase A; EC 2.6.1.1; EC 2.6.1.7 from Mus musculus (Mouse)
P05202 kynurenine-oxoglutarate transaminase (EC 2.6.1.7) from Mus musculus
PFams: Aminotran_1_2
430 amino acids: PaperBLAST, CDD, BRENDA::P05202
42% identical to

P00507 mitochondrial aspartate aminotransferase subunit (EC 2.6.1.1) from Rattus norvegicus
AATM_RAT / P00507 Aspartate aminotransferase, mitochondrial; mAspAT; Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Plasma membrane-associated fatty acid-binding protein; FABPpm; Transaminase A; EC 2.6.1.1; EC 2.6.1.7 from Rattus norvegicus (Rat)
P00507 aspartate transaminase (EC 2.6.1.1) from Rattus norvegicus
PFams: Aminotran_1_2
430 amino acids: PaperBLAST, CDD, BRENDA::P00507
41% identical to

AATM_DANRE / Q7SYK7 Aspartate aminotransferase, mitochondrial; mAspAT; Glutamate oxaloacetate transaminase 2a; Glutamic-oxaloacetic transaminase 2a, mitochondrial; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Transaminase A; EC 2.6.1.1; EC 2.6.1.7 from Danio rerio (Zebrafish) (Brachydanio rerio)
PFams: Aminotran_1_2
428 amino acids: PaperBLAST, CDD, SwissProt::Q7SYK7
41% identical to

P00505 Aspartate aminotransferase, mitochondrial (EC 2.6.1.23; EC 2.6.1.1; EC 2.6.1.7) from Homo sapiens
AATM_HUMAN / P00505 Aspartate aminotransferase, mitochondrial; mAspAT; Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Plasma membrane-associated fatty acid-binding protein; FABPpm; Transaminase A; EC 2.6.1.1; EC 2.6.1.7 from Homo sapiens (Human)
P00505 aspartate transaminase (EC 2.6.1.1) from Homo sapiens
TC 9.A.70.1.1 / P00505 Mitochondrial aspartate amino transferase of 430 aas and 1 TMS, AAT or GOT2 from Homo sapiens
PFams: Aminotran_1_2
430 amino acids: PaperBLAST, CDD, BRENDA::P00505
41% identical to

P17174 cytoplasmic aspartate aminotransferase (EC 2.6.1.1; EC 2.6.1.3) from Homo sapiens
AATC_HUMAN / P17174 Aspartate aminotransferase, cytoplasmic; cAspAT; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cCAT; Glutamate oxaloacetate transaminase 1; Transaminase A; EC 2.6.1.1; EC 2.6.1.3 from Homo sapiens (Human)
P17174 aspartate transaminase (EC 2.6.1.1); glutamine-phenylpyruvate transaminase (EC 2.6.1.64) from Homo sapiens
PFams: Aminotran_1_2
413 amino acids: PaperBLAST, CDD, BRENDA::P17174
41% identical to

AAT3_ARATH / P46644 Aspartate aminotransferase 3, chloroplastic; Protein YELLOW-LEAF-SPECIFIC GENE 4; Transaminase A; EC 2.6.1.1 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Aminotran_1_2
449 amino acids: PaperBLAST, CDD, SwissProt::P46644
40% identical to

AATM_CHICK / P00508 Aspartate aminotransferase, mitochondrial; mAspAT; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Transaminase A; EC 2.6.1.1; EC 2.6.1.7 from Gallus gallus (Chicken)
PFams: Aminotran_1_2
423 amino acids: PaperBLAST, CDD, SwissProt::P00508
40% identical to

P00503 aspartate aminotransferase subunit (EC 2.6.1.1) from Sus scrofa
AATC_PIG / P00503 Aspartate aminotransferase, cytoplasmic; cAspAT; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cCAT; Glutamate oxaloacetate transaminase 1; Transaminase A; EC 2.6.1.1; EC 2.6.1.3 from Sus scrofa (Pig)
P00503 aspartate transaminase (EC 2.6.1.1) from Sus scrofa
PFams: Aminotran_1_2
413 amino acids: PaperBLAST, CDD, BRENDA::P00503
40% identical to

AATC_CHICK / P00504 Aspartate aminotransferase, cytoplasmic; cAspAT; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cCAT; Glutamate oxaloacetate transaminase 1; Transaminase A; EC 2.6.1.1; EC 2.6.1.3 from Gallus gallus (Chicken)
PFams: Aminotran_1_2
412 amino acids: PaperBLAST, CDD, SwissProt::P00504
40% identical to

HMM-only sequences

(Since these sequences' annotations are outside the definition for ilvE, HMM hits that are over 40% similar to these sequences will be scored as moderate confidence.)

ATNH_EMENI / Q5AV02 Branched-chain-amino-acid aminotransferase atnH; Aspercryptin biosynthesis cluster protein H; EC 2.6.1.- from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
PFams: Aminotran_4
396 amino acids: PaperBLAST, CDD

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for ilvE.)

ARAT1_THELN / H3ZPL1 Aromatic-amino-acid aminotransferase 1; ARAT-I; AROAT; EC 2.6.1.57 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)
PFams: Aminotran_1_2, Asp_aminotransf
417 amino acids: PaperBLAST, CDD, SwissProt::H3ZPL1
94% identical to

A0A060PQX5 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Thermococcus sp.
PFams: Aminotran_1_2, Asp_aminotransf
417 amino acids: PaperBLAST, CDD

O85746 tyrosine aminotransferase monomer (EC 2.6.1.88) from Klebsiella pneumoniae
TYRB_KLEPN / O85746 Tyrosine aminotransferase; TyrAT; Aromatic-amino-acid transaminase; Aspartate aminotransferase; EC 2.6.1.5; EC 2.6.1.57; EC 2.6.1.1 from Klebsiella pneumoniae
PFams: Aminotran_1_2
397 amino acids: PaperBLAST, CDD, SwissProt::O85746
83% identical to

RR42_RS33490 Aromatic-amino-acid aminotransferase (EC 2.6.1.57) from Cupriavidus basilensis FW507-4G11
PFams: Aminotran_1_2
400 amino acids: PaperBLAST, CDD, reanno::Cup4G11:RR42_RS33490
57% identical to

AO353_18575 tyrosine aminotransferase (EC 2.6.1.57) from Pseudomonas fluorescens FW300-N2E3
PFams: Aminotran_1_2
397 amino acids: PaperBLAST, CDD, reanno::pseudo3_N2E3:AO353_18575
43% identical to

Psest_0779 tyrosine aminotransferase (EC 2.6.1.57) from Pseudomonas stutzeri RCH2
PFams: Aminotran_1_2
398 amino acids: PaperBLAST, CDD, reanno::psRCH2:GFF765
43% identical to

PfGW456L13_4396 tyrosine aminotransferase (EC 2.6.1.57) from Pseudomonas fluorescens GW456-L13
PFams: Aminotran_1_2
397 amino acids: PaperBLAST, CDD, reanno::pseudo13_GW456_L13:PfGW456L13_4396
42% identical to

b0928 aspartate aminotransferase (EC 2.6.1.1; EC 2.6.1.57; EC 2.6.1.27; EC 2.6.1.5; EC 2.6.1.7; EC 2.6.1.3) from Escherichia coli K-12 substr. MG1655
P00509 aspartate aminotransferase (EC 2.6.1.1; EC 2.6.1.7; EC 2.6.1.3) from Escherichia coli (strain K12)
AAT_ECOLI / P00509 Aspartate aminotransferase; AspAT; Transaminase A; EC 2.6.1.1 from Escherichia coli (strain K12)
A0A140ND68 aspartate transaminase (EC 2.6.1.1) from Escherichia coli
D3H0F7 aspartate transaminase (EC 2.6.1.1) from Escherichia coli
P00509 aspartate transaminase (EC 2.6.1.1) from Escherichia coli
PFams: Aminotran_1_2
396 amino acids: PaperBLAST, CDD, BRENDA::A0A140ND68
42% identical to

AO356_03985 L-phenylalanine transaminase (EC 2.6.1.57) from Pseudomonas fluorescens FW300-N2C3
PFams: Aminotran_1_2
397 amino acids: PaperBLAST, CDD, reanno::pseudo5_N2C3_1:AO356_03985
42% identical to

Pf6N2E2_2632 tyrosine aminotransferase (EC 2.6.1.57) from Pseudomonas fluorescens FW300-N2E2
PFams: Aminotran_1_2
397 amino acids: PaperBLAST, CDD, reanno::pseudo6_N2E2:Pf6N2E2_2632
42% identical to

HP15_858 phenylalanine aminotransferase (EC 2.6.1.57) from Marinobacter adhaerens HP15
PFams: Aminotran_1_2
395 amino acids: PaperBLAST, CDD, reanno::Marino:GFF879
41% identical to

Ac3H11_1015 Aromatic-amino-acid aminotransferase (EC 2.6.1.57) from Acidovorax sp. GW101-3H11
PFams: Aminotran_1_2, DegT_DnrJ_EryC1, Asp_aminotransf
396 amino acids: PaperBLAST, CDD, reanno::acidovorax_3H11:Ac3H11_1015
40% identical to

Ac3H11_1358 L-leucine transaminase; L-isoleucine transaminase (EC 2.6.1.42) from Acidovorax sp. GW101-3H11
PFams: Aminotran_1_2, Asp_aminotransf
401 amino acids: PaperBLAST, CDD